Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"intrathecal"”.
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Competency Guide For Intrathecal Pump Nurses
… to improve quality care for patients who have Intrathecal Baclofen Therapy (ITB) and Intrathecal Pain Therapy (ITP). The intrathecal pump therapy has been used for many years and if not done effectively complications can be fatal.</p> <p>Programming errors, administering incorrect medication …
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Psychosocial Variables in Outpatients Receiving Intrathecal Baclofen or Pain-Pump Therapy
… daily functioning, and quality of life. Intrathecal baclofen and pain pump therapy have been viable treatment options for those patients with severe spasticity who have not responded to less invasive treatments. Several small studies have examined quality of life and patient-reported …
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Clinical effects of long-term intrathecal morphine versus morphine/bupivacaine administration in cancer patients.
Contains fulltext : 18646.pdf (Publisher’s version ) (Open Access)
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Long-Term Survival In Metastatic Melanoma Patients With Leptomeningeal Disease Treated With Intrathecal Interleukin-2
… options. We assessed the safety and efficacy of intrathecal interleukin-2 (IT IL-2) in metastatic melanoma patients with LMD.</p> <p><strong>METHODS:</strong> We reviewed the outcomes of 43 consecutive metastatic melanoma patients with LMD who were treated with IT IL-2 from 2006 to 2014 in a …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… pattern in DRG and CNS resulting from intrathecal delivery of AAV serotypes 5, 8, and 9. The results obtained demonstrate differential tropism of AAV vectors for subpopulations of primary afferent neurons and some brain areas. The second part of this thesis characterizes interactions …
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A comparison of intrathecal morphine or fentanyl on the duration of postoperative analgesia at Namibian teaching hospitals in Windhoek
… short-term and long-term effects. Addition of intrathecal opioids has been shown to produce a dense block and enhance analgesic effect. The objective of the study was to compare the duration of postoperative analgesia of intrathecal morphine or fentanyl for femur fracture surgery at Namibian …
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Cognitive, Academic, and Neuropsychological Effects of Treatment
<p>This study explored the effects of number of intrathecal chemotherapies and time off therapy on cognitive, achievement, and neuropsychological functioning of post treatment children with Acute Lymphocytic Leukemia (ALL). Participants consisted of sixteen sibling pairs between the ages of eight …
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Spinal anaesthesia for brachytherapy for carcinoma of the cervix a comparison of two dose regimes of hypebaric bupivacaine
… of hyperbaric bupivacaine, when combined with intrathecal fentanyl, for spinal anaesthesia for brachytherapy for carcinoma of the cervix. This procedure is performed as a day case at Groote Schuur Hospital.
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Investigating the Contribution of the Inflammasome to Persistent Pain States
… (GFAP) or neuronal marker NeuN. While daily intrathecal administration of Ac-YVAD-CMK, a cell-permeant caspase-1 inhibitor, significantly attenuated established behavioural hypersensitivity following L5 SNT, ASC-/- and NLRP3-/- mice developed behavioural hypersensitivity normally in the …
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Injectable hydrogels for the improved delivery of treatments in spinal cord injury
… drug delivery outcomes following intrathecal and intraparenchymal injection of hydrogel within rat thoracic SCI contusion lesions. Intraparenchymal hydrogel injection but not intrathecal administration afforded prolonged release of biomacromolecules locally within spinal cord …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… nocifensive behavior and inflammatory proteins. Intrathecal injection of CGRP increased nocifensive responses to mechanical stimulation up to 48 hours and this stimulatory effect was blocked by the antagonist peptide CGRP8-37 and a protein kinase A inhibitor. Results from my cellular studies …
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Perioperative caearean section pain management at Groote Schuur hospital ? an audit
… recommended interventions were not done at all (intrathecal long-acting opioid, preoperative oral paracetamol, intraoperative and postoperative NSAID, intraoperative intravenous dexamethasone), two intraoperative interventions were done poorly (intravenous paracetamol 15.5%, local anaesthetic …
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Pathological role of double-stranded DNA antibodies in multiple sclerosis.
… Anti-dsDNA antibodies have been found intrathecally and bordering lesions in multiple sclerosis patients and in view of their known pathogenity in lupus nephritis the aim of this project was to further investigate their role in multiple sclerosis. Using the acute experimental allergic …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… was reduced in chronic SCI rats with the intrathecal administration of Apocynin, 4-OXO-TEMPO, Tirilazad, and U-83836E. Apocynin was used to further examine the ability of ROS and lipid peroxidation products to generate neuropathic pain behaviors in chronic SCI rats. Apocynin was found to …
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The role of the ventrolateral medulla in the pressor reflex to static muscular contraction
… by muscular contraction. In another study intrathecal injections of kynurenic acid in the upper thoracic spinal cord attenuated the pressor reflex to muscular contraction. In addition, glutamate immunoreactive neurons were identified in the same region of the VLM as reticulospinal …
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Development of A Gene Therapy for Creatine Transporter Deficiency
… we next compared neonatal ICV delivery with intrathecal lumbar puncture (IT) delivery in adult mice, as IT is much more clinically relevant. Both routes were assessed at 13 and 24-week endpoints. ICV resulted in a greater increase in brain creatine than IT at both endpoints. However, IT …
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Presurgical Behavioral Medicine Evaluation for Implantable Devices for Pain Management: Clinical Effectiveness for Predicting Outcomes
… specifically spinal cord stimulators and intrathecal drug delivery systems. The Presurgical Behavioral Medicine Evaluation (PBME) algorithm was designed to evaluate patients prior to spine surgery. The algorithm showed strong outcome predictability in previous studies (Block et al., 2003). …
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Male-specific mechanisms in a murine model of nociplastic pain
… direct spinal GABAergic disinhibition by intrathecal injection of the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a …
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The role of Substance P and its signaling pathways in central sensitization
… in unidentified dorsal horn neurons. Moreover, intrathecal injection of SP induced increased expression of pCaMKII alpha and PKC gamma in the superficial dorsal horn. Also, it was demonstrated that activation of CaMKII and PKC plays an important role in SP-mediated pain transduction. \r\n This …
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Male-specific mechanisms in a murine model of nociplastic pain
… direct spinal GABAergic disinhibition by intrathecal injection of the GABAA receptor antagonist bicuculline or the GABAB receptor antagonist CGP 52432. In females, spinal GABAB receptor inhibition, but not GABAA receptor inhibition, followed by vibration stimulation was able to trigger a …
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