Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"intranasally"”.
-
Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… volume and extended the therapeutic window of intranasally administered OPN peptide to at least 6 h post-middle cerebral artery occlusion (MCAO). Our findings support the development of GNPs as a promising drug delivery platform for the intranasal treatment of ischemic stroke and, potentially, …
-
Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus
… vaccine components, increasing their stability. Intranasally delivered FI-BRSV co-formulated with CpG ODN and PP performed better than FI-BRSV alone, or FI-BRSV formulated with either adjuvant individually, in terms of inducing protective immunity against BRSV in mice. Furthermore, mice that …
-
Characterization of Lung Inflammation Induced by Exposure to Fipronil
… We studied the same by exposing mice to fipronil intranasally (N=8) or orally (N=7) for 7 days followed by collection of blood, broncho-alveolar lavage (BAL) fluid and lung tissues. Control mice were given corn oil (N=15). The oral and intranasal exposure routes were chosen because these are the …
-
Determining the Innate and Adaptive Immune Responses to Vesicular Stomatitis Virus Vaccine Vectors
… analyzed the T-cell responses in mice vaccinated intranasally with M51R or M51R-F. Results showed no significant difference between M51R and M51R-F vectors in either CD8+ or CD4+ T-cell responses. To address the memory phase mice were vaccinated with M51R or M51R-F and 40 days later challenged …
-
Accelerating development of treatments for trigeminal neuralgia using intranasal delivery and a novel behavioral screening device for rats.
… exposure and side effects. Lidocaine was intranasally administered to rats, and the trigeminal nerve and trigeminally-innervated structures (teeth, temporomandibular joint (TMJ), and masseter muscle) accumulated up to 20-fold higher tissue concentrations of lidocaine than the brain and …
-
The development of a novel vaccine against avian influenza H7N9 virus
… in the vaccinated host. LAIVs are administered intranasally and do not require an adjuvant because they are capable of stimulating stronger immune responses compared to IIVs. However, one common drawback towards the use of LAIVs is the possibility of virulence reversion. On the contrary, …
-
Protective Immunity in Mice Immunized with the Nfa1 Protein for Pathogenic Naegleria fowleri Infection
… or intranasal route, and then infected intranasally with N. fowleri trophozoites. In regardless of the immunization routes, Nfa1-immunized mice showed the prolonged mean time to death. The specific immunoglobulin G (IgG), IgG subclass, IgA and IgE of mice induced against Nfa1 protein …
-
The Effects of DDAVP on Speed of Accessing Long-Term Memory and Incidental Learning in Healthy Male and Female Volunteers
… and forty-three healthy males (age 18-34) intranasally received either 60 ug DDAVP in 0.6 ml of solution or 0.6 ml of saline 20 minutes prior to testing. DDAVP did not affect response time on the computerized task; however, when response time control trials were subtracted from the …
-
Focused ultrasound-mediated drug delivery to the brainstem
… and microbubbles to enhance the accumulation of intranasally administered agents at the FUS-targeted brain location with significantly lower systemic exposure than that of FUS-BBBD. The objective of this thesis was to evaluate the feasibility, safety, and efficacy of the two FUS-mediated …
-
Immunomodulatory effect of the Acanthocheilonema viteae product ES-62 in arthropod extract models of asthma
… clarified. ES-62 is also given as a therapeutic intranasally for the first time in mice with induced airway allergy.;In the second model employed, HDME allergy, phosphorylcholine-specific IgM antibodies were produced in the presence of ES-62 in combination with HDME but not HDME alone. ES-62 …
-
Utilization of Cholera Toxin B as an Adjuvant for the Subunit PspA Vaccine, Provides Effective Protection against Streptococcus pneumoniae Challenge
… of the subunit vaccine, PspA, administered intranasally (i.n.) in conjunction with CTB as an adjuvant. Our results indicated increased survival in mice immunized with both PspA and CTB accompanied with reduced lung bacterial burden, increased levels of S. pneumoniae-specific IgG subclass …
-
A Novel Mouse Model of Asthma Induced by Cockroach
… mouse model. METHODS: CR allergen was delivered intranasally to BALB/C mouse, TLR-4 mutant (C3H/HeJ) or wild type (C3H/HeN) mouse without any adjuvant. Asthma was induced by CR, CR with endotoxin added (10,000 EU/mouse) or endotoxin-depleted CR, respectively. RESULTS: CR asthma model can be …
-
The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
… model for aerosol exposure mice were vaccinated intranasally (IN) with strain RB51 and challenged IN with B. abortus strain 2308, strain RB51 did not protect. Protection against Brucella is mediated through TLRs 2, 4 and 9. The addition of TLR 2 or TLR 4 and a trend with TLR9 agonists with …
-
Διέγερση των ωοθηκών σε γυναίκες για εξωσωματική γονιμοποίηση και ενδοσαλπιγγική μεταφορά γαμετών
… Group I: (271 cycles). Buserelin (Β: 1 mg/day, intranasally) as short protocol (271 cycles) starting on cycle day I, accompanied by the administration of HMG (3 amp/day) from cycle day 3 until HCG administration or long protocol. According to this, Buserelin is given for at least 15 days until …
-
A comparison of the efficacy and safety of intranasal sufentanil/midazolam and ketamine/midazolam for sedation and analgesia in a paediatric population undergoing multiple dental extractions
… either ketamine 5 mg/kg or sufentanil 20μg intranasally, 20 minutes before induction of surgery in this randomised double-blind study. All the children in both groups in addition concurrently received nasal midazolam 0,3 mg/kg. For induction of anaesthesia, sevoflurane in nitrous oxide and …
-
A Flagellin-Poxvirus Antigen Vaccine: Strengths and Limitations
… humoral response to poxvirus antigens delivered intranasally (i.n.) or intramuscularly (i.m.), intramuscular immunization resulted in significantly high titers of anti-L1R and B5R IgG. Flagellin/poxvirus antigen fusion proteins were more potent than flagellin and L1R and B5R as separate proteins …
-
Membrane-Bound Immunomodulators As Adjuvants In A Cell Culture-Based Avian Influenza Vaccine
… adjuvanted vaccines delivered subcutaneously and intranasally resulted in significantly higher antibody titers than vaccinating with inactivated virus alone. Vaccination with C3d adjuvanted virions by either route completely eliminated viral shedding after challenge with live virus and the GMCSF …
-
Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… protection against lethality when delivered intranasally, with increased protection afforded by a refined formulating containing the most immunogenic proteins. Also, we have shown that antigen-specific humoral responses play a significant role in the protection induced by various AuNP-coupled …
-
Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters
… intercellular transport of large volumes of intranasally instilled inoculum between nasal epithelial cells has been recently reported in hamsters. Intercellular transport in the nose could potentially be used for the non-invasive delivery of drugs to the brain. This thesis looks at the …
-
Effects of Exercise on Immune Function in Young, Adult, and Aged Mice: Increased Survival and a Decrease in Inflammation
… with 50uL of A/PR/8/34 influenza virus (40HAU) intranasally under light anesthesia (Isoflurane) and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-3min of moderate exercise (8-12m/min) on a motorized treadmill 4hr post-infection and then exercised similarly …
Page 1 of 3