Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"intranasal vaccination"”.
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Surface Engineering of Protein Nanoparticles for Intranasal Delivery
Intranasal delivery of vaccines offers a promising alternative approach to invasive intramuscular injection, with additional benefits such as inducing mucosal antibodies and cellular responses to neutralize pathogens before entering systemic circulation. However, nasal secretions and mucosa are …
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Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid
… antigen. A comparison of these formulations for intranasal delivery of heat-inactivated influenza virus combined with LTR192G adjuvant was made in vivo in a rabbit model. Individual rabbit sera were tested for seroconversion against hemagglutinin (HA), the major surface antigen of influenza. It …
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Plant-derived Murine IL-12 and Ricin B-Murine IL-12 Fusions
… vitro in mouse splenocytes and in vivo in mouse intranasal vaccination trials. Plant-derived mIL-12 triggered induction of interferon-gamma secretion from mouse splenocytes as well as stimulation of cell proliferation with comparable activities to those observed for the animal-cell-derived …
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Field comparison of intranasal and injectable bovine respiratory disease vaccination on beef calf antibody concentrations, average daily gain, and bovine respiratory disease morbidity
… injectable modified live viral (IJ-MLV) group, intranasal homologous boost (IN-MLV) group, or intranasal heterologous boost (IN-KV) group. Vaccines were administered at birth, ‘‘turnout’’ (~2 months of age), and weaning. Blood samples and weights were collected at ‘turnout’, two weeks post …
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The ability of TLR agonists to upregulate Brucella abortus strain RB51 mediated protection in a murine respiratory model
… model for aerosol exposure mice were vaccinated intranasally (IN) with strain RB51 and challenged IN with B. abortus strain 2308, strain RB51 did not protect. Protection against Brucella is mediated through TLRs 2, 4 and 9. The addition of TLR 2 or TLR 4 and a trend with TLR9 agonists with …
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Unraveling the host innate immune response to a respiratory model of Brucella abortus
… DC maturation and function in vitro and upon intranasal inoculation in vivo compared to strain RB51SOD or strain 2308. Due to safety concerns of live vaccines, irradiated and heat killed vaccines were also tested; only live strain RB51 infected DCs induced significant (p≤0.05) DC function …
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An exploratory study of Helicobacter suis control strategies
… eradication of the bacterium from the stomach. Vaccination with whole-cell lysate was shown to protect against a subsequent H. suis infection in a mouse model. However, it was not known which bacterial proteins are important for induction of protective immunity against H. suis infections. In …