Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"intranasal delivery"”.
-
Surface Engineering of Protein Nanoparticles for Intranasal Delivery
Intranasal delivery of vaccines offers a promising alternative approach to invasive intramuscular injection, with additional benefits such as inducing mucosal antibodies and cellular responses to neutralize pathogens before entering systemic circulation. However, nasal secretions and mucosa are …
-
Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines
… Despite the effectiveness of these drugs, the delivery routes are not ideal for first-line, outpatient treatments. A skilled caregiver must be present to administer drugs intravenously, and the social stigma associated with rectal administration results in low compliance. Intranasal delivery is …
-
Intranasal delivery of therapeutics targeted to CSF and Brain
… fluid barrier limit the systemic delivery of therapeutics to the brain and cerebrospinal fluid (CSF) respectively. Therapeutic agents targeting CNS are currently being administered by invasive routes which are not patient compliant and do not allow frequent administration. …
-
Accelerating development of treatments for trigeminal neuralgia using intranasal delivery and a novel behavioral screening device for rats.
… orofacial and brain structures involved. Intranasal administration targets these structures while minimizing systemic exposure and side effects. Lidocaine was intranasally administered to rats, and the trigeminal nerve and trigeminally-innervated structures (teeth, temporomandibular joint …
-
Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… from recent clinical trails have reported that intranasal administration of non-inhaled 100% medical grade CO2 is an effective and safe treatment for migraine and allergic rhinosinusitis, but the exact mechanism of action of CO2 in treating these diseases is not well understood. Activation of …
-
Strategies to improve BCG-mediated protection from <i>Mycobacterium tuberculosis</i>
… in BALB/c and C57BL/6 mice. A comparison of intranasal and parenteral immunisation of BCG showed that whilst both routes elicited comparable T cell responses in the spleen, only intranasal delivery elicited specific T cell responses in the lung lymph nodes and these responses were further …
-
Design of Human Serum Albumin and Adenovirus Conjugation via Catcher/Tag Molecular Glue
<p>Adenovirus (Ad) has been the ideal cargo delivery mechanism, and its moderate immunological response makes it ideal for in vivo gene therapies since its discovery in 1953. However, the robust immunogenicity of the Ad capsid and low vaccine absorption via mucous membranes and epithelium put a …
-
An Investigation of the Role of Insulin Deficiency and Loss of PI3K-Akt Signaling Downstream Regulators GSK3β -CREB Signaling in the Pathogenesis of the Diabetic Brain
… that replacement of insulin in the brain via intranasal delivery prevents diabetes mellitus (DM) mediated neurodegeneration. Insulin is speculated to act through activation of PI3K-Akt signaling. We hypothesized that the neurodegenerative changes and cognitive impairments observed in the …
-
Focused ultrasound-mediated drug delivery to the brainstem
… currently available techniques for brain drug delivery are either invasive (e.g., convection-enhanced delivery) or lack targeting to the diseased site (e.g., intranasal brain drug delivery). Novel techniques that can noninvasively overcome the BBB are critically needed for the treatment of …
-
Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… to introduce a novel formulation strategy for intranasal delivery of two low permeation candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock …
-
Bioadhesive Microparticles and Liposomes of Anti-Parkinson Drugs for Nasal Delivery
The nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The …
-
Strategies for the induction of mucosal immunity against hepatitis B virus.
… derivative of LT (LTK63) was evaluated with intranasal delivery. We also evaluate the potential of administering immunostimulatory complexes (comprised of HBsAg complexed with antibodies against HBsAg) by a mucosal route and determine whether immune responses are modulated by using CT or CpG …
-
Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
Delivery of therapeutic agents to the brain is significantly hampered by the blood- brain barrier (BBB). Typically, only small, lipophilic molecules can freely enter the brain parenchyma following systemic administration. During the initial development phases, many drug candidates for neurological …
-
The Intrinsic Caspase Death Pathway in Stroke Neurodegeneration
… caspase for the intrinsic cell death pathway. Intranasal delivery of a novel, cell membrane-penetrating inhibitor for caspase-9 confirmed the pathogenic relevance of caspase-9 activity in stroke. Caspase-9 inhibition provided neurofunctional protection and established caspase-6 as its …
-
Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid
The interest in and importance of systemic drug delivery via the nasal route have expanded in recent decades since nasal administration offers an interesting alternative for the conventional oral and parenteral drug delivery routes. In this thesis, the nasal route was selected as an alternative …
-
Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… As such, we are interested in leveraging the intranasal (IN) pathway to bridge the gap between animal studies and clinical application. However, the advantages of the IN pathway are tempered by low efficiency, and, therefore, we have applied our gelatin nanoparticle (GNP) technology to aid …
-
Progettazione e studi preformulativi di formulazioni nanotecnologiche per la somministrazione intranasale di composti neuroattivi
… una via di somministrazione innovativa, la via intranasale (IN), poco invasiva e facile da autosomministrare. Ad oggi, è considerata dalla comunità scientifica una valida alternativa alla via parenterale, in quanto consente un'elevata velocità d'azione, poiché il farmaco può essere captato …
-
Prophylaxis of disease caused by bacterial pathogens of man
… also been investigated, and a novel cancer drug delivery system based on targeted lysis of drug-containing liposomes by α-toxin has been devised and patented. F. tularensis is the etiological agent of tularemia, a disease of man that is found in most countries in the Northern hemisphere and most …
-
Nanocarriers for nose-to-brain delivery: a novel strategy for the treatment of CNS disorders
… The blood-brain-barrier (BBB) precludes the delivery of drugs to the brain, preventing the therapy of a number of neurological disorders. In the last 20 years, intranasal (IN) administration has gained great attention in research and has been investigated with regard to its feasibility to …