Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"intranasal"”.
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Intranasal Naloxone Adminstration Education
… project focused on the provision of education on intranasal naloxone administration to healthcare providers in Lake County in order to educate patients, their families, peers, and members of their social network. Fatal opioid overdose rates from prescribed or illicit opioids are four times greater …
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Surface Engineering of Protein Nanoparticles for Intranasal Delivery
Intranasal delivery of vaccines offers a promising alternative approach to invasive intramuscular injection, with additional benefits such as inducing mucosal antibodies and cellular responses to neutralize pathogens before entering systemic circulation. However, nasal secretions and mucosa are …
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Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines
… rectal administration results in low compliance. Intranasal delivery is an attractive alternative because it requires little training, is easily performed by non-medical personnel, carries a low risk of injury to the patient, and can provide a rapid therapeutic effect. However, formulating a …
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Novel intranasal GNRs-DNA vaccines against human papillomavirus infection
… the murine bone marrow-derived macrophages cell. Intranasal immunization ofBALB/c mice with GNRs-DNA resulted in YFP expression in nasal and lung tissuesin one day. Three doses (3 × 480ng plasmid DNA per mouse) elicited neutralizingantibodies in the serum and antibody secreting cells in spleen …
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Intranasal delivery of therapeutics targeted to CSF and Brain
… and do not allow frequent administration. Intranasal delivery of therapeutics to target CSF and brain is a noninvasive route of administration which is patient compliant and allows frequent administration. In the current study, the plausibility of delivering ziconotide and cefotaxime to CSF …
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Single-dose pharmacokinetics of intranasal levetiracetam in healthy dogs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… As such, we are interested in leveraging the intranasal (IN) pathway to bridge the gap between animal studies and clinical application. However, the advantages of the IN pathway are tempered by low efficiency, and, therefore, we have applied our gelatin nanoparticle (GNP) technology to aid …
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Impact of prophylactic intranasal oxytocin administration on symptoms of post-traumatic stress
… This study served to evaluate the efficacy of intranasal oxytocin pre-treatment on symptoms related to PTSD. The hypotheses are that oxytocin will decrease fear and anxiety, and increase reward-seeking behaviors. Sprague Dawley rats were assigned to three groups (Control, Stress, Oxytocin, and …
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Delivery of a Small Hydrophobic and Large Hydrophilic Molecule via Intranasal Route
The intranasal route of drug administration is widely known to be a non-invasive route that has the potential to carry a drug directly to the central nervous system (CNS). Drugs with low solubility and large molecular weight are two common problems encountered which interfere with the delivery of …
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The Effect of Intranasal Oxytocin on Neural Functioning in Widow(er)s
… and 3) neuropharmacological manipulation via intranasal oxytocin (INT OT) administration. Method: A mixed sample of 37 spousally-bereaved older adults (CG =17; ncomplicated grief (NCG) = 20), completed the AAT, with 3 stimulus categories (spouse, stranger, and generic grief) during fMRI …
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Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… to introduce a novel formulation strategy for intranasal delivery of two low permeation candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock …
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Intranasal treatment with a novel immunomodulator mediates innate immune protection against lethal Pneumonia Virus of Mice.
Respiratory syncytial virus (RSV) is the major causative agent of acute lower respiratory tract infections in infants and young children. Unfortunately, there are no licensed RSV vaccines available, and the few treatment options for high-risk individuals are either extremely costly or cause severe …
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Accelerating development of treatments for trigeminal neuralgia using intranasal delivery and a novel behavioral screening device for rats.
… orofacial and brain structures involved. Intranasal administration targets these structures while minimizing systemic exposure and side effects. Lidocaine was intranasally administered to rats, and the trigeminal nerve and trigeminally-innervated structures (teeth, temporomandibular joint …
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Improving dopamine monitoring with NCAM and the effects of intranasal oxytocin on dopamine signaling in the rat brain
… were evoked and recorded, rats were exposed to intranasal OXT (n=3) or saline (n=3) and OXTinduced changes DA signaling was monitored for 1 h. Chapter 2 Results: Intranasal OXT increased DA signaling (i.e. peak height of DA current), relative to controls. Conclusions: NCAM coating expedites the …
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Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
… cytotoxic effector immunity, and utilizing the intranasal mucosal route of immunization to ensure efficient trafficking to the genital mucosal tumors. Overall, I hypothesized that intranasal HPV peptide vaccination employing the combination of TLR9 and NKT cell ligands, (CpG-ODN and α-GalCer, …
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The comparative efficacy of inhaled methoxyflurane and intranasal fentanyl for the pre hospital management of cardiac and or visceral pain
… and efficacy of inhaled Methoxyflurane and intranasal Fentanyl for the management of pain of cardiac or viscera/ aeitology and to secondly assess the usefulness of an alternative pain assessment tool utilised by the WA Ambulance Service. DESIGN: Retrospective study. PARTICIPANTS: Patients …
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Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… from recent clinical trails have reported that intranasal administration of non-inhaled 100% medical grade CO2 is an effective and safe treatment for migraine and allergic rhinosinusitis, but the exact mechanism of action of CO2 in treating these diseases is not well understood. Activation of …
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