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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"intramolecular interaction"”.
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Spectroscopic Model Studies of Nad Intramolecular Interaction
Made available in DSpace on 2014-12-09T17:36:39Z (GMT). No. of bitstreams: 1 7013477.pdf: 3291955 bytes, checksum: a1c62c1f9189ef295f299b984bd4d859 (MD5) Previous issue date: 1969
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Regulation of The Escrt Function of Alix
… in these ESCRT-mediated processes requires ALIX interaction with the ESCRT-III component CHMP4 as well as a cargo protein. However, the native form of ALIX contains a default intramolecular interaction between N-terminal Bro1 domain and C-terminal PRD (proline-rich domain), leading to a closed …
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Regulation of PKCalpha and the role of PKC in neuroblastoma cell migration
… it is maintained in a closed conformation by intramolecular interactions. Upon activation these interactions are disrupted by binding proteins, membranes and activators. We have previously seen that stimulation with carbachol induces a transient translocation of PKCalpha to the plasma …
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Analysis of the recruitment of the class I myosin Myo5p to endocytic sites in Saccharomyces cerevisiae
… we demonstrate the existence of an inhibitory interaction between the Myo5p tail homology 1 (TH1) domain and the most C-terminal portion of the myosin, which includes the SH3 domain. Such interaction precludes the SH3-mediated Myo5p association with Verprolin and Myo5p recruitment to the …
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FTIR study of carboxylic acids and tyrosines in bacteriorhodopsin
… to tyrosine-26 or tyrosine-64. A model based on intramolecular interaction is built to elucidate the spectral change observed during the cycle. This model places the three aspartic acids and the two tyrosines near the chromophore of bR. One aspartic acid and one tyrosine, together with a …
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Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
… that facilitate chromatin targeting via their interactions with acetylated histones. Although Brd4 has been known to be involved in E2-mediated transcriptional regulation, it was unclear how Brd4 regulates E2 function and whether the involvement of Brd4 in transactivation and transrepression is …
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Mutable mechanics in biomaterials : a study of trichocyte keratin and Nvjp-1 protein
… in the presence of Zn ions with more stable intramolecular metal coordination complexes at higher ion concentrations. As pH increases, deprotonation of histidine amino acids weakens the electrostatic repulsion, allowing a greater intramolecular interaction and a shift to a folded …
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Understanding the activation mechanism of the Chk1 kinase
… provided evidence of a compact shape and an intramolecular association of the Chk1RD with the Chk1KD. A putative Chk1RD-binding site on the Chk1KD surface was identified and disrupted by mutagenesis, resulting in partial increase of Chk1FL kinase activity, thus supporting an inhibitory role …
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Block Copolymer Solutions: Transport and Dynamics, Targeted Cargo Delivery, and Molecular Partitioning and Exchange
… structure, translational motion, inter- or intramolecular interaction, dynamics, and exchange kinetics. Therefore, this dissertation describes applications of versatile NMR methods to reveal the fundamental behaviors of block copolymer self-assemblies, such as their dynamic stability, cargo …
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The intramolecular domain interactions and phosphatase activation mechanisms of Shp2
… PDGFRβ induced a significant FRET increase via intramolecular interaction between C-SH2 and phosphotyrosine 580 (pY580). The phosphotyrosine 542 (pY542) has an adverse position despite a favored surrounding amino acid sequence such that it can only bind to C-SH2 in the absence of pY580. In …
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Amyloidogenesis of a Type III-dependent Hpa1 and Structural analysis of a drug-pump repressor DNA complex
… domain polypeptide, suggesting that the intramolecular interaction of Hpa1 between the two helix domains keeps Hpa1 in a non-fibrillar state. In addition, the fibrils formed by full length Hpa1, the N-terminal truncated Hpa1 (55-138) and synthesized polypeptide (ASPLTQMLMNIVGEILQAQ) …
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Structural Basis of Signal Transduction within Environmental Sensing PAS Regulated Ser/Thr Kinases
… study, we unexpectedly identified a novel intramolecular interaction involving the hPASK PAS-A domain and a short-linear PAS interacting motif (PIM) in the C-terminal region to the PAS-A and STK linker and important for nuclear localization of hPASK. Additionally, our NMR and modeling data …
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Lanthanide-based single-molecule magnets: A rational design by chemical intuition
… showed that despite f−electrons having weak interactions with ligand field, it is possible to tune the magnetic properties of lanthanide-based complexes using ring currents, control of covalency and peripheral ligand substitution. Furthermore, di-nuclear acetate bridged lanthanide complexes …