Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"intraflagellar transport"”.
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Mutation of Polaris, an Intraflagellar Transport Protein, Shortens Neuronal Cilia
… is directly involved in a microtubule-dependent transport process called intraflagellar transport (IFT). In order to determine the importance of polaris in the development of neuronal cilia, cilium length and numerical density of cilia were quantitatively assessed in six different brain regions …
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Towards structural characterisation of ciliary rootlets, ciliary caps and intraflagellar transport
Cilia elongation and homeostasis require the transport of building blocks and signalling molecules between the ciliary base and tip through a process called intraflagellar transport (IFT). IFT is driven by multiple copies of the ciliary motor proteins kinesin-2 and dynein-2 attached to train-like …
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The role of intraflagellar transport during the disassembly of the Leishmania mexicana flagellum
… work has suggested a large reduction in the intraflagellar transport (IFT) system can lead to flagellum disassembly in Leishmania. However, it is not clear how or when the IFT system changes during this disassembly process. Here, we show that the flagellum disassembly is associated with a …
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Chemical Biology of Dynein
… with various Activities) motor protein that transports cellular cargoes towards the microtubule minus-end. Despite its essential role in intracellular transport, dynein remains the least understood cytoskeletal motor. With speeds >25 μm/min in cells, dynein's cellular functions are …
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Genetic analysis of cGMP-dependent chemosensory signal transduction pathways in the detection of bacterial metabolites by C. elegans
… is discretely regulated by different classes of intraflagellar transport proteins that function in cilia.
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… and function. Furthermore, DYF-11 undergoes intraflagellar transport (IFT) and may function at an early stage of IFT-B particle assembly. Our results suggest that glia are required for multiple aspects of sensory organ function. Moreover, as thrombospondin 1 is a glial-secreted protein …
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Multi-Step Trafficking Pathway for Regulation of the Protein Composition of the Chlamydomonas Flagellar Membrane during Cilium-Generated Signaling
… cells conditionally depleted of the anterograde intraflagellar transport motor protein, kinesin-2. Furthermore, studies on the fate of SAG1-HA-C65 showed that it was shed into the medium in a detergent soluble membrane fraction during flagellar adhesion. This work provides new insights into …
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Defining the molecular composition and organisation of Transition fibres in Trypanosoma brucei and their roles in flagellar assembly and length control
… membrane docking and regulate the trafficking of intraflagellar transport (IFT) proteins required for flagellar assembly. Transition fibres are present in all ciliated organisms yet only a handful of TF proteins have been identified in mammalian cells. We hypothesise that there are a number of …
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Nuovi approcci molecolari per lo studio di malattie monogeniche rare: utilizzo dell’exome sequencing per la ricerca di geni malattia
… in DYNC2H1 (MIM 603297), a gene involved in intraflagellar transport pathways of cilia that has been previously associated to the disease (Dagoneau et al., 2009; Merrill et al., 2009). The substiution has been found in homozygosity in the probands of one of the two families JATD and in …
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Role of WDR35 in the formation of functional cilia
… the transition zone. Once inside the cilia intraflagellar transport (IFT) proteins move the cargo along microtubules ‘railways’ of the axoneme. IFTs are known to assemble in two protein complexes, IFTA and IFTB protein complexes. IFT-B complex known to be made of 16 different proteins …
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Regulation and function of genes involved in drosophila ciliogenesis
… machinery, particularly in the process known as intraflagellar transport (IFT). dila mutants also display reduced male fertility because of aberrant basal body function, which leads to a disorder in sperm individualisation. Thus DILA is required for the differentiation of all ciliated cells in …
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Characterization of the Placenta-Specific 8.1 Gene Function during Zebrafish Embryogenesis
… at the ciliary base, possibly by modulating intraflagellar transport through ubiquitination modifications.</p><p>Our in vivo studies of zebrafish plac8.1 have uncovered pleiotropic functions of plac8.1 during development. In addition, the overexpression experiments shed light on mechanisms …
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Mutationsanalyse des intraflagellaren Transportprotein-Gens hTg737 bei Patienten mit Situsanomalien und hereditären Nierenerkrankungen
… als 100 kb verteilen. hTg737 kodiert für das intraflagellare Transport (IFT)-Protein Polaris. Dieses hat eine Größe von 833 AS und weist 10 Kopien eines Tetratricopeptide Repeats (TPR) auf. Es existieren zwei Mausmodelle mit Defekten in Tg737. Mäuse, die homozygot für die Insertionsmutation …