Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"intraepithelial lymphocytes"”.
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Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
… located between the IECs that have been named intraepithelial lymphocytes (IELs). As the main lymphoid population within the intestinal barrier, IELs are thought to have an important role in intestinal homeostasis maintenance, as well as a role in intestinal inflammatory and autoimmune diseases …
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
… several bacteria and microorganisms. Intestinal intraepithelial lymphocytes (IELs) are T cells that are interspersed between epithelial cells, above the basement membrane. This makes them one of the first immune cells to encounter and provide defence against invasive microbes. Studies have shown …
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The role of nonclassical MHC class I products in the development and function of CD8+ T cells
… the majority of CD8cαα+ TCRαβ intestinal intraepithelial lymphocytes (iIELs) develop independently of classical class I expression and are dependent on the nonclassical class I product Qa-2 for their maturation.
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The role of mucus in the cross talk between gut bacteria and the host
… as a first line of defence. Furthermore γδ intraepithelial lymphocytes (IELs) respond to the invading bacteria that circumvent the mucus barrier. In this study two approaches were used to investigate the role of mucus in intestinal homeostasis; firstly the impact of γδ IELs on the mucus …
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Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… to this specialised immune system are the Intraepithelial Lymphocytes (IELs). These cells are uniquely located between Intestinal Epithelial Cells (IECs) ready to respond to exogenous antigens in the intestinal lumen. The intestinal immune system is constantly influenced, not only by the …
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Investigating the potential utilisation of black soldier fly (Hermetia illucens) as an alternative protein source in tilapia and carp feed
… thickness, and goblet cell density, while intraepithelial lymphocytes abundance and enterocyte microvilli length were elevated only at 40% BSF meal. Posterior intestinal endochitinase A, slc6a18, and cytokines (il1β, tnfα, il10) in either the intestine or head kidney were not significantly …
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Role of the colonic lymphoglandular complex in mucosal immunity in swine
… specific for B and T lymphocyte subsets. Lymphocytes were compartmentalized into B (T-independent) and T-dependent (internodular) areas. CD4[superscript]+ cells were more plentiful than CD8[superscript]+ cells. In nodules, CD4[superscript]+ cells were common but CD8[superscript]+ cells …
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Role of the Gut Microbiome in Cancer Immunotherapy Efficacy and Side Effects
… populations and increased CD8+ Teffs in small intraepithelial lymphocytes. Histological assessment and lipocalin-2 measurement were used to evaluate anti-CTLA-4-induced gut inflammation. 16S rRNA sequencing identified specific bacterial taxa associated with gut toxicity (Dubosiella and genera …
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Identifying Protein Kinase Tbk1 As A Novel Inhibitor of Intestinal Tumorigenesis
… is important for the crosstalk of IECs with intraepithelial lymphocytes that maintain the expression of immunosuppressive cytokine IL-10. These studies present the first <em>in vivo </em>model demonstrating the function of TBK1 during the process of intestinal adenoma development and suggest …
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THE ROLE OF MOLECULAR SIGNATURES IN COMPLICATED CELIAC DISEASE
… Based on their molecular signatures, aberrant intraepithelial lymphocytes (aIELs) and monoclonal TCRγ rearrangement, RCD patients are differentiated into RCD type 1 (RCD1) and RCD type 2 (RCD2). This distinction is challenging but essential, as RCD2 is associated with enteropathy-associated …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
T lymphocytes are critical components of an effective adaptive immune response, with different subsets performing proinflammatory and immuno-suppressive roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. …
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Butyrophilin family genes as putative coeliac disease risk loci
… gluten, is characterised by an increase in intraepithelial lymphocytes (IELs), and mucosal damage, leading to symptoms such as villous atrophy, abdominal pain, malabsorption and malnutrition (5). Currently, the only treatment for CeD is following a gluten-free diet (6). The genetic risk for …
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Molecular Mechanisms and Antigen Receptor Requirements for Lymphocyte Adaptation to Intestinal Tissues
… in the lamina propria. However, CD8αα-expressing intraepithelial CD4+ T cells (CD4- IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. Using intravital microscopy, we find distinct cell dynamics of intestinal Tregs and …