Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"intradermal"”.
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Intradermal needle-free powdered drug injection
This thesis presents a new method for needle-free powdered drug injection. The design, construction, and testing of a bench-top helium-powered device capable of delivering powder to controllable depths within the dermis is presented. This device uses a jet of gas undergoing choked flow to entrain …
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Intradermal Administration of RiVax, a Ricin Vaccine
… of RiVax. To this end, we have compared intradermal (ID) vs. IM administration of RiVax by evaluating the following parameters of vaccine efficacy: (1) short-term antibody responses and protection of mice from a 10X LD50of ricin following a three dose vaccine regimen; (2) long-term …
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Treatment of bacterial infections by intradermal medication
A General Practitioner is not capable of scientific observation. He is easily prejudiced in favour of any new treatment, and has not the means at hand to test out results, using controls &c. But his greatest interest is in treatment. if any method: of treatment will relieve his patients of their …
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Microneedle array patches for skin hyperthermia and enhanced intradermal drug delivery
… heating up a thick skin model was confirmed. For intradermal drug delivery, hydrogel- forming single needles were fabricated, which were then coated with a model drug to investigate how deep these devices deliver the drug in a skin model. As the drug was coated and dried on the surface of needles, …
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Lymph-targeted intradermal delivery of antiretroviral agents via dissolving polymeric microarray patches
… uptake of antiretrovirals are highly desirable. Intradermal application of nanoparticles can have a positive impact on the lymphatic availability of therapeutic agents, but common intradermal injections come with many drawbacks. Dissolving polymeric microarray patches (MAPs) are …
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Sweating After Repeated Intradermal Injections or Iontophoresis of Pilocarpine or Acetyl Beta-Methylcholine
Made available in DSpace on 2014-12-09T23:34:01Z (GMT). No. of bitstreams: 1 6910740.pdf: 3066275 bytes, checksum: 4caa6469732971f10b539d15d2a1475d (MD5) Previous issue date: 1968
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… profile of these difficult-to-deliver compounds. Intradermal delivery of poorly soluble drugs involves the delivery of drugs into the skin to exert localised effects. However, relatively few drugs possess the necessary properties to passively traverse the skin and remain in the skin in a high …
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The Intradermal Skin Test in the Horse: Value as a Diagnostic Modality in Equine Allergies
… conflicting results in regards to equine intradermal skin testing and its use in defining causative antigens in IgE mediated diseases such as equine recurrent airway obstruction (RAO). This study was divided into two experiments. In the first experiment of this study, the hypothesis tested …
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Effect of intradermal normal saline, listening to music, and insertion difficulty on pain of IV insertion
… to compare the effects of listening to music and intradermal saline injection on the sensory and affective components of pain of IV catheter insertion. The relationships among the difficulty of IV insertion and pain were also examined. Ninety four hospitalized patients requiring insertion of an IV …
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Phenotypic Analysis and Localization of Leukocytes at the Site of Intradermal Injection of Phytohemagglutinin in Chickens
… immuno-competence. PHA is typically injected intradermally (i.d.) into the skin (e.g. wing web) and the tissue swelling response is then monitored, whereby the extent of the swelling positively relates to the individual’s cellular immune system capabilities. Although i.d. injected PHA was …
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EXPLORING EQUINE ASTHMA: PATHOGENESIS INSIGHTS AND DIAGNOSTIC CHALLENGES
… insights. Notably, our findings based on intradermal testing revealed that SEA-affected horses predominantly exhibit late-phase type I hypersensitivity, whereas MEA-affected horses manifest type IV hypersensitivity. Furthermore, our investigations demonstrated associations between distinct …
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Microneedle-mediated transdermal drug delivery of biotherapeutic macromolecules
… drug delivery systems, capable of facilitating intradermal and transdermal passage of biotherapeutic macromolecules. The model protein ovalbumin was incorporated into polymeric MN systems using commonly employed industrial manufacturing techniques and sterility was successfully demonstrated. …
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… Using growing feathers (GF) as a novel intradermal test site along with concurrent blood sampling, we examined the time-course, phenotype, and severity of PAMP (LPS, PGN, MDP, or poly I:C) -elicited leukocyte and cytokine responses in both the peripheral blood circulation (automated …
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Clinical and Histological Characteristics of Melanocytic Nevus in External Auditory Canals and Auricles
… in 35 cases with junctional, compound and intradermal nevi treated in Ajou University Hospital, Korea between 2001 and 2011. Patient demographics; location, shape and diameter of nevi; and pathologic results were analyzed according to the location, EACs (23 cases) and auricles (12 cases). …
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Mucosal and systemic immune responses induced by immunisation of cotton rats with recombinant adenoviruses
… cell numbers in the respiratory tract than intradermal, intraperitoneal or enteric immunisation. Protection correlated with gD-specific antibody levels such that intranasal immunisation, even 3 months following vaccination, conferred complete, while intradermal or enteric immunisation …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… administration routes, such as subcutaneous and intradermal delivery, where the structural and compositional complexity of the injection site can markedly influence drug release, diffusion, and bioavailability. Consequently, there is a growing need of reliable dissolution methods that mimic key …
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Dissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals
Dissolvable microneedles are an intradermal drug delivery technology with exciting potential for widespread distribution of minimally invasive, self-administered medicines and vaccines. The most popular manufacturing method for medical dissolvable microneedles is micromoulding, a process which can …
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T-Zell-priming außerhalb sekundärer lymphatischer Gewebe
… Modell, bei dem reife, antigenbeladene DC intradermal appliziert wurden, untersucht. Im murinen Modell zeigte sich, dass die gerichtete Anreicherung von Lymphotoxin-alpha am Tumor zu dessen Zerstörung führte, welche durch T-Zellen vermittelt wurde, und mit der Induktion eines tertiären …
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Effects of lead ingestion on the immune function in quail
… the cell-mediated immune response to an intradermal injection of phytohemagglutinin. Corticosterone suppressed cell-mediated immunity more than lead. The primary total antibody response to chukar (Alectoris graeca chukar) erythrocytes was significantly suppressed in lead-dosed quail fed …
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