Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"intracranial tumors"”.
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First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study
Objective: Brain tumors represent some of the most treatment refractory cancers, and there is a clinical need for additional treatments for these tumors. Domesticated dogs are the only other mammalian species which commonly develop spontaneous brain tumors, making them an ideal model for …
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MRI at 3 T of brain functions and fibre tracts adjacent to intracranial tumors
… for preoperative evaluation of patients with intracranial tumors (Paper 2); to investigate the effect of glioma resection on the spatial extent of fMRI activation as compared to the normal within-subject variability (Paper 3); to determine whether the apparent diffusion coefficient (ADC) and …
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Characterization of electrospun DLPLGA nanofibers for a drug delivery system for intracranial tumors and AVMs
… to create the ideal drug delivery system for intracranial arteriovenous malformations (AVMs) and tumors, D, L poly-(lactice-poly-glycolide) (DLPLGA) nanofibers were electrospun in a tetrahydrofuran (THF) solvent. Three different concentration ratios of DLPLGA, 85/15, 80/20, and 75/25 were …
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Risk, Outcomes, and Costs in Neurosurgery – The New Frontier in Health Services Research
… surgical resection of primary or metastatic intracranial tumors, after controlling for other risk factors. We not find smoking to be associated with early (30-day) peri-operative morbidity or mortality. All levels of anemia were significantly associated with prolonged length of …
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Targeting The Blood-Brain Barrier With A Non-Canonical Iron-Mimicry Mechanism
… virus thymidine kinase-mediated gene therapy of intracranial tumors for molecular genetic imaging and suicide gene delivery with ganciclovir. Finally, we expand our data by analyzing a large panel of primary CNS tumors through comprehensive tissue microarrays. Together, our approach and results …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
Meningioma is one of the most commonly diagnosed intracranial tumors in dogs and humans. Treatment failures resulting in local recurrence and death remain common in tumors of high grade, prompting a need for additional therapeutic options that are both effective and affordable. Genetic modification …
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Morphological and Immunocytochemical Investigation of Canine Oligodendrogliomas
… markers. Primary spontaneous canine intracranial tumors share many of the biologic behaviors and pathologic features of their human counterparts. The objectives of this study were to determine if associations existed between five histomorphologic features (mitoses, cellular atypia, …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… ability of BTZ and MRZ to be delivered to brain tumors in a relevant orthotopic system. The goal of this study was to determine the kinetics and mechanism of death induced by proteasome inhibitors in GBM and to compare the ability of BTZ and MRZ to cause proteasome inhibition in orthotopic brain …
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Accelerator-Based Neutron Branchytherapy
… MeV. The focus of this work is the treatment of intracranial tumors which limits the diameter of the dose delivery needle tube to 6 mm. A prototype needle tube, a tube-in-tube design with cooling water running in between the inner and outer tubes to cool the beryllium target located at the tip of …
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Multimodality Imaging of Tumor Vasculature and Metabolism
… to monitor the initiation and development of intracranial tumors and assess the changes in tumor vascular volume and permeability in a mouse model of breast cancer brain metastases. Using a 9.4T system, high resolution anatomic MRI and dynamic susceptibility contrast (DSC) perfusion MRI were …
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Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… TMZ treatment of mice bearing orthotopic tumors (generated by xenografting GBM9 neurospheres) leads to acquired-TMZ resistance resulting in tumor recurrence. In order to understand the basis for therapy-driven TMZ resistance, we generated and functionally characterized ex-vivo cultures …
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Single-Voxel- versus Multi-Voxel-Protonen-MR-Spektroskopie bei verschiedenen intrakraniellen Läsionen
Diese Arbeit untersucht die Fragestellung ob bei der Untersuchung von gesundem Hirngewebe und pathologischen,intrakraniellen Läsionen mittels Singelvoxel- versus Multivoxel-MR-Protonen-Spektroskopie signifikant unterschiedliche Ergebnisse bestehen. Untersucht wurden Hirntumoren der WHO-Grade 2 bis …
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Carnosine’s inhibitory effect on glioblastoma cell growth is independent of its cleavage
… it remains one of the most treatment-refractory intracranial tumors; the median over survival after standard treatment is only 14.6 months. Experiments by Letzien et al. demonstrated that L-histidine mimics the anti-neoplastic effect of carnosine in three glioblastoma cell lines investigated. In …