Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"intracranial self-stimulation"”.
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EFFECTS OF MU OPIOID RECEPTOR AGONISTS ON INTRACRANIAL SELF-STIMULATION IN THE ABSENCE AND PRESENCE OF “PAIN” IN RATS
… use is constrained by high abuse liability. Intracranial self-stimulation (ICSS) is a preclinical behavioral procedure that has been used to assess abuse potential of opioids, and drug-induced facilitation of ICSS is interpreted as an abuse-related effect. ICSS can also be used as a …
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Electrical stimulation of reward sites in the ventral tegmental area of the rat increases dopamine transmission in the nucleus accumbens as measured by in vivo microdialysis
… and after 15-min periods of electrical brain-stimulation at sites in the ventral tegmental area (VTA) that supported intracranial self-stimulation (ICSS). In the first experiment, both ICSS and yoked-stimulation of the VTA evoked significant increases in extracellular concentrations of DA, its …
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Shuttlebox Self-Stimulation Behavior Following Intracerebral Microinjections of Morphine Into the Ventral Tegmental-Substantia.
… which rats will lever-press for electrical brain stimulation as well as decrease the current intensity required for this self-stimulation. In the shuttlebox paradigm, the animal crosses from one side of the case to the other in order to turn the current on and off. Similar doses of morphine will …
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Investigating the influence of LH-projecting BLA neurons upon motivated behavioral responding and appetitive learning
… has indicated that the projection may support intracranial self-stimulation (ICSS). Further experiments with in vivo extracellular electrophysiological recordings from LH-projecting BLA neurons may also shed light on the encoding properties of these neurons during appetitive learning.
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A functional MRI study of the distributed neural circuitry of learning and reward
… shown that the reward magnitude of electrical stimulation to structures within this system increases with increasing current and frequency. In this study, operant conditioning with intracranial self-stimulation of the medial forebrain bundle (MFB) was used to correlate the rewarding quality of …
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Determinants of Abuse-Related Effects of Monoamine Releasers in Rats
… releasers in two preclinical assays in rats: intracranial self-stimulation (ICSS) and drug discrimination. First, this work confirmed and expanded upon previous findings that selectivity for promoting release of dopamine versus serotonin is one determinant of abuse-related effects produced by …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in reward-motivated behavior. One way to assess these preclinical effects of cannabinoids is …
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Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
… stretching (pain-stimulated behavior) or depress intracranial self-stimulation (ICSS) (pain-depressed behavior), whereas, IP injection(s) of lipopolysaccharide (LPS) served as a chronic/acute inflammatory-related noxious stimulus to stimulate mechanical allodynia (pain-stimulated behavior) or …
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Influence of Pramipexole on Probability Discounting and Ventral Pallidal Function: Assessments in Parkinsonian-Like Rats
<p>People with neuropathologies who are treated with dopamine agonists may be at risk to develop impulse control disorders. The overall goal of this dissertation project was to expand our knowledge on the neuropsychopharmacology of dopamine agonist-induced impulsivity. At the time this dissertation …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… S-MEPH produced biphasic profiles in an assay of intracranial self-stimulation (ICSS), but R-MEPH produced greater ICSS facilitation than S-MEPH. Our data were the first to demonstrate stereospecific effects of MEPH enantiomers and suggests that the predominant dopaminergic actions of R-MEPH (i.e. …