Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"intracisternal A particle"”.
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Analysis of variation in PIWI-interacting RNA (piRNA) expression in testes of different mouse strains
… of a very young retrotransposon, the murine intracisternal A-particle (IAP) in the strains being compared. We found that the presence of an IAP in the region being expressed, in just one of the strains, (±10kb) was highly correlated with differential expression of the cluster between both …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… where an endogenous retrovirus (ERV) of the intracisternal A-particle (IAP) class was spontaneously inserted upstream of the agouti coat colour gene, resulting in variable IAP promoter DNA methylation, variable expressivity of coat phenotype, and environmentally modulated transgenerational …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… which includes the murine-specific intracisternal A particle (IAP) elements. To prevent their mobilisation and suppress the function of the TE- encoded regulatory sequences, TEs are generally targeted by repressive histone modifications and DNA methylation. The Avy allele results …
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Mechanisms of epiallelic variation in mouse
… Such loci are termed “epialleles”. In mice, the intracisternal A-particle (IAP) subclass of TEs account for most variably methylated TEs. Over 50 constitutively variably methylated IAPs (VM-IAPs) have been identified in the C57BL/6J mouse strain. This thesis investigates the mechanisms driving …
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Epigenetic Response to Low-Dose Ionizing Radiation
… protein (CabpIAP) metastable epialleles and at intracisternal a particle (IAP) elements across the genome were quantified using Sequenom technology. Second, three imprinted genes, Peg3, Nnat, and H19, were assessed for methylation changes in differentially methylated regions (DMRs) that regulate …