Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"intracerebral hemorrhage"”.
-
Peripheral Leukocytes and Intracerebral Hemorrhage
… suffer significant disability from spontaneous intracerebral hemorrhage (ICH) every year. No proven treatment is available that improves ICH outcomes. Since hematoma volume is the strongest predictor of ICH outcome, limiting hematoma expansion has been the primary goal of recent ICH clinical …
-
Mechanisms of Brain Edema Formation in Mouse Models of Intracerebral Hemorrhage
… causes major neurologic deterioration following intracerebral hemorrhage (ICH), mainly resulting from the disruption of the blood-brain barrier (BBB) by multiple mediators, including inflammatory mediators and thrombin. The objective of our study was to investigate the mechanisms by which …
-
Evaluating Blood Pressure Methods in Non-traumatic Intracerebral Hemorrhage: A Two-site Prospective Observational Study
… complex in the treatment of acute non-traumatic intracerebral hemorrhage (ICH). Despite mean arterial pressure (MAP) being the most reliable measure of noninvasive automatic oscillometric (NIBP) in clinical practice, clinicians instead rely on systolic and diastolic blood pressure (SBP and DBP) …
-
Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
… States, and the most severe form is known as intracerebral hemorrhage, which is bleeding into the brain. The goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal …
-
The Role of Perivascular Fibrosis In Post-Stroke Glymphatic Impairment and Cerebral Amyloid Angiopathy
… fibrosis can be used to diagnose CAA following intracerebral hemorrhage (ICH). To test these hypotheses, I first performed experimental stroke in young and aged wild-type mice, then measured basement membrane fibrosis and CSF flow using a variety of biochemical and physiological techniques. I …
-
Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
… brain and induce behavioral recovery in mouse intracerebral hemorrhage (ICH) stroke model. However, many of the grafted hNSCs did not survive the transplantation, which may have reduced therapeutic potential. In this study, we postulated that hNSCs over-expressing Akt1 transplanted into the …
-
Inflammatory Response Following Hemorrhagic Stroke: The Role of Cytokines
… stroke, whether aneurysmal subarachnoid hemorrhage (aSAH) or intracerebral hemorrhage (ICH), the rapid increase in inflammation and an imbalance of inflammatory cytokines can lead to the development of secondary ischemic injury. Several animal models have been developed to investigate …
-
Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
… cerebrovascular pathologies, including intracerebral hemorrhage (ICH) is unclear. Hereditary cerebral amyloid angiopathy (HCAA) is a rare familial form of CAA in which mutations within the Aβ peptide cause an increase in vascular deposits. Since the interaction between normal wild-type …
-
Identifying Observational and Causal Factors for Cardiovascular Diseases through Large-scale Cohorts
… risk factor profiles for subarachnoid hemorrhage and intracerebral hemorrhage, two subtypes of hemorrhagic stroke, differed quantitatively, suggesting distinct pathogenesis. I found U-shaped observational associations between estimated glomerular filtration rate (eGFR) and CHD. …
-
HMGCR Pathway Mediates Cerebral-Vascular Stability and Angiogenesis in Developing Zebrafish
Intracerebral hemorrhage (ICH) is a severe form of stroke, with a high mortality rate and often resulting in irreversible neurological deterioration. Although animal studies have provided insight into the etiology of the disease, many of the causative genes and mechanisms implicated in …
-
Injectable chemokine-releasing gelatin matrices for enhancing endogenous regenerative responses in the injured rat brain
Brain injuries acquired from hemorrhage, ischemic strokes and trauma affect millions worldwide each year and often cause irreversible loss of neural tissue that disrupts vital neurological functions. Cell transplantation has traditionally been the strategy for achieving neuroregeneration but …
-
The Impact of Hyperglycemia on Post-Reperfusion Outcomes in Patients with Hyperacute Ischemic Stroke
… recovery and complications such as symptomatic intracerebral hemorrhage. Patients were grouped into ≥180 mg/dL and < 180 mg/dL admission glucose for comparison between groups. Additionally, patients were grouped into diabetic groups to compare against dichotomous good outcome (mRS 0-2) and bad …
-
Ruolo neuroprotettivo dell'Acido α-Lipoico in un modello di sovraccarico di ferro da emorragia intracerebrale.
… di ferro in un processo di emorragia intracerebrale.
-
Microglia and Complement in Alzheimer's Disease with Cerebral Amyloid Angiopathy
… explain the high frequency of microbleeds and hemorrhage associated with CAA and may offer a novel therapeutic target to reduce these life-threatening events.</p>
-
Evaluation and Feasibility of a Head Positioning Intervention in Patients with Intraparenchymal Hemorrhage
<p>Stroke caused by intraparenchymal hemorrhage (IPH) is most commonly the result of hypertension-induced blood vessel rupture in the brain and is associated with devastating disability and high rates of death. To date, no intervention has improved outcomes in IPH stroke patients; however, head …
-
MR-tomographische Darstellung intracerebraler Blutungen mit und ohne Therapie
Ausgehend von der Frage über die Signalgebung der mit rt-PA- und/oder PAI behandeltenHämatome im Vergleich zu unbehandelten Hämatomen, bestand die Zielsetzung der vorliegenden Arbeit darain, die Blutungen der unterschiedlichen Behandlungsgruppen zu detektieren um anschließend ihre Signalintensität …
-
MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… stroke is divided into two categories: intracerebral and subarachnoid hemorrhage. Intracerebral hemorrhage (ICH) is due to the rupture of a small artery (arterioles) which bleeds within the brain tissue. It is often associated with chronic high blood pressure and the symptoms often begin …