Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"intracellular trafficking"”.
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Intracellular trafficking of Leishmania major peptidases
… to the lysosome. Thus, in this project, the intracellular localisations of eight other L. major peptidases were analysed by fluorescence microscopy, after tagging the enzymes with green fluorescent protein (GFP). The candidate peptidases were chosen by bioinformatics analyses and predictions …
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The Role of ERp57 in Hras Intracellular Trafficking and Function.
… was to determine if ERp57 participates in Ras trafficking and function. First, the effect of ERp57 knock down by siRNA technology on Hras function was studied; there was a reduction in ERp57 cellular levels that led to a decrease of active ras. Second, specific anti-ERp57 antibodies were …
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Mechanisms of Cytotoxicity and Intracellular Trafficking for Gene Delivery Polymers
… to determine the effect polymer structure has on intracellular events. The effect of different polyamine lengths in copolymers on cellular uptake, the effect of modifying end groups of trehalose-containing polymers on transfection efficiency, and the effect of different linker lengths between …
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Polyethylene glycol copolymer nanocarriers: Biocompatibility, uptake and intracellular trafficking in neurons
… in their clathrin-mediated endocytosis (CME), intracellular trafficking and uptake efficiency in neurons and glia, assessed using immunocytochemistry, confocal microscopy and live cell imaging. We have observed that, irrespective of size and charge, a portion of all SFNCs are internalized by …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
… of arenaviral entry. Beyond its role in intracellular trafficking and pH-dependent membrane fusion of GP-C complex, SSP might be involved in virus assembly and budding. Studies employing immunogold electron microscopy indicated that GP-C complex clusters into microdomains of 120 nm size …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
… of arenaviral entry. Beyond its role in intracellular trafficking and pH-dependent membrane fusion of GP-C complex, SSP might be involved in virus assembly and budding. Studies employing immunogold electron microscopy indicated that GP-C complex clusters into microdomains of 120 nm size …
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Investigation of the intracellular trafficking pathways of the dermonecrotic toxin family
… this thesis is to further define the entry and trafficking pathways of the dermonecrotic toxin family composed of related AB toxins whose members induce dermonecrosis upon injection into animal skin. The dermonecrotic toxins Pasteurella multocida toxin (PMT) from Pasteurella multocida (P. …
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The discovery of a role of FBXO7/PARK15 in intracellular trafficking
… development of novel therapies challenging. Intracellular trafficking pathways, including Kinesin and Dynein motor transport and the secretory pathway, are emerging as dysregulated pathways in PD contributing to Alpha-synuclein accumulation and neuronal dysfunction. These mechanisms can be …
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Deciphering Underlying Mechanisms Of Photoreceptor Outer Segment Degradation; Involvement Of Intracellular Trafficking
… task RPE cells are involved in, is daily uptake, trafficking and degradation of shed photoreceptor outer segment (POS). It has been shown that with age and as a result of cellular stress this process can become impaired. Impairment in this unique phagocytic process can lead to degeneration of the …
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Using Advanced Fluorescence Microscopy to Analyze Intracellular Trafficking of FcRn In Live Cells
The file named "GanZhou.pdf" is the primary dissertation file. All other files ("*.mov") are supplemental files and may be viewed individually.
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An Investigation into the Intracellular Trafficking and Processing Pathways of Amyloid Precursor Protein
… disease (AD) pathology. It undergoes a complex intracellular trafficking and processing itinerary to produce toxic amyloid-β peptides that accumulate in extracellular plaques in the brains of AD patients. Its cleavage is dependent on several different secretase enzymes that are distributed …
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Quantitative Studies of Intracellular Trafficking of Two Classes of Resident Golgi Apparatus Proteins
… the ER and Golgi at steady-state. Retrograde trafficking of these Golgi proteins has been demonstrated experimentally mandating the existence of a dynamic equilibrium between the Golgi apparatus and ER. Our published studies also included the development of a quantitative method for analysis …
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Systemic and Intracellular Trafficking of Long-chain Fatty Acids in Lactating Dairy Cattle
… regulate transfer of long-chain polyunsaturates. Intracellular fatty acid binding proteins (FABP) are cytoplasmic proteins that are hypothesized to be essential for fatty acid transport and metabolism by accelerating longchain fatty acid uptake and targeting to intracellular organelles, such as …
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
Polarized epithelial cells usually line body cavities, providing a barrier between two dissimilar environments. Distinct apical and basolateral membrane surfaces are maintained by sorting proteins in the biosynthetic and endocytic pathways. Influenza hemagglutinin is sorted to the apical membrane …
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Biochemical Investigation of the Intracellular Trafficking of Non-Viral and Hybrid Gene Therapy Vectors
We also used reverse transcriptase inhibitor 3'-azido-3'-deoxythymidine (AZT) applied of post-transfection time increments to determine the timeframe of reverse transcription, thereby estimating endosomal escape of VLP. MLV were observed to achieve reverse transcription rapidly, with more than half …
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Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr
… is well known for its degradation and recycling trafficking. Recent evidence shows that these cell surface receptors translocate from cell surface to different cellular compartments, including the Golgi, mitochondria, endoplasmic reticulum (ER), and the nucleus to regulate physiological and …
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Regulation of the Intracellular Trafficking of Ajuba by Cell Density and Cell Cycle-Dependent Mechanisms
<p>The intracellular localization of Ajuba, a LIM domain-containing protein, holds essential value for various cellular activities. Previous studies from the laboratory have implicated Ajuba as a repressor of ATR in human cells. This study focused on unveiling the intricate mechanisms governing …
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Understanding campylobacter jejuni cytolethal distending toxin intracellular trafficking, structure function relationships, and host cell interaction
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
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