Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"intracellular survival"”.
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IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis
… with LNA-GapmeRs significantly reduced intracellular Mtb growth in mouse and human macrophages and reduced proinflammatory cytokine production. In addition, in vivo treatment with MIR99AHG LNA-GapmeRs reduced the mycobacterial burden in the lung and spleen. In vivo LNA-GapmeR treatment …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… the ΔrfaPΔfimH double mutant strongly impairs intracellular persistence within macrophages and dendritic cells and, most notably, completely abolished intracellular survival within intestinal epithelial cells. Consistently, the associated pro-inflammatory response — including IL-8, CCL20, …
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Mechanisms and ecological implications of resistance to predation by heterotrophic ciliates expressed by marine bacteria
… including toxicity, biofilm formation and intracellular survival. Intracellular survival was employed by Shewanella spp. as T. pyriformis feeding on these organisms led to expulsion of Shewanella-filled vacuoles into the external milieu. The role of intracellular survival as an …
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Influence of Rhodococcus Equi on the Respiratory Burst of Resident Alveolar Macrophages From Horses
… that could partially explain its facultative intracellular survival.
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Proteomic analysis of the Mycobacterium avium-containing phagosome membrane
… M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
… of this study was to investigate the extra- and intracellular iron acquisition mechanisms of N. gonorrhoeae and determine the role of the TonB and TdTs in this process.The ability of gonococci to acquire potential exogenous iron sources was determined by plate bioassay. Gonococcal growth was …
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Identification and characterization of the acid phosphatase from Francisella tularensis and its potential role in pathogenesis
Successful intracellular pathogens resist or prevent the formation of antimicrobial substances produced by professional phagocytes including, toxic oxygen intermediates of the respiratory burst. Purified acid phosphatases (ACP) from Leishmania donovani and Legionella micdadei have been shown to …
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Endothelial cells and basement membrane : a co-regulatory unit for fibroblast growth factor-2 in hyperglycemic stress
… was still evident as FGF-2 signaling down an intracellular survival pathway was inhibited by glucose.
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils to cause the emerging tick-transmitted disease, human granulocytic anaplasmosis (HGA). Following entry, the pathogen replicates within a host cell-derived vacuole that fails to mature along the endocytic …
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Finding Typhoid Mary: Identifying Latent Carriers of Salmonella enterica serovar Typhimurium
… in which bacteria can adapt and survive in an intracellular environment. This intracellular survival is key to latent infections persisting within a host. It is biologically plausible that, in order to survive in a latent state, S. Typhimurium would up-regulate genes that would facilitate …
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Eukaryotic protein mimicry as an infection strategy for Ehrlichia chaffeensis
… in monocytes to promote bacterial uptake and intracellular survival and that TRP120 was involved in this activation event. To identify the specific mechanism of pathway activation, we hypothesized that TRP120 is a Wnt signaling ligand mimetic that initiates Wnt pathway activity through direct …
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Glyoxylate Metabolism in Mycobacterium smegmatis
… synthase (MLS), may also be important for the intracellular survival of the tubercle bacillus; yet, no studies have been done to determine its in vivo role. We present here results of genetic studies of MLS in the saprophyte Mycobacterium smegmatis, and show that MLS, unlike ICL, is dispensable …
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… of S. aureus VF on host immune responses during intracellular or extracellular infections. Accessory gene regulator (agr) controls VF expression and intracellular survival. Our goal was to determine mammary epithelial cells (MEC) responses to intracellular infection and subsequent …
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Ochrobactrum anthropi: a soil bacterium for the study of Brucella virulence
… remain unclear. Molecular characterization of intracellular survival processes of Brucella will provide guidance for additional prevention and control measures. One of the features that distinguishes Brucella is that they do not express classic virulence factors. Thus identification of …
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Virulence associated functions and vaccine potential of the burkholderia mallei type three secretion effector BopA
… immunological and cellular responses. The intracellular survival of B. mallei within murine macrophage J774.2 cells requires the type III secretion system (TTSS), although the effector protein(s) involved are unknown. Additionally, previous reports have documented that B. mallei TTSS is …
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Mechanisms of anaerobic nitric oxide detoxification by Salmonella enterica serovar Typhimurium
… Key to Salmonella’s pathogenicity is the survival of several components of the innate immune system encountered during infection. Reactive oxygen and nitrogen species (ROS and RNS) are an integral part of this antibacterial defence of the immune system. Exposure to ROS and RNS occurs …
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Tackling Mycobacterium abscessus infection in Cystic Fibrosis
… with chronic lung infection, such as enhanced intracellular survival, increased antibiotic resistance, and metabolic adaptations to the host environment. Second, I assessed the role of an inserted element containing an active methyltransferase in M. a. massiliense. Infection experiments with an …
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Pleiotropic regulatory function of the lysr family transcriptional regulator cpsy during streptococcus iniae systemic infection
… in whole blood, but is dispensable for intracellular survival in macrophages. Susceptibility of the cpsY deletion mutant to killing in whole blood is not due to a growth defect because inhibition of neutrophil phagocytosis rescues the mutant to WT levels. <i>S. iniae</i> does not alter …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
… and PGEx decreased phagocytosis and increased intracellular survival. We also investigated the effects of eicosanoid inhibitors during mucosal and systemic infection models. During experimental C. albicans vaginitis, treatment with inhibitors locally resulted in decreased fungal burden and PGE2 …
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CONTRIBUTIONS OF SIGMA-B AND PRFA TO STRESS RESPONSE AND VIRULENCE GENE EXPRESSION IN LISTERIA MONOCYTOGENES
… under stress conditions, but is highly active intracellularly. Additionally, I used qRT-PCR to determine that sigmaB contributes directly to prfA expression at the P2 promoter region. One gene initially identified in the microarray analysis to be sigmaB-dependent is lmo1433, which is predicted …
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