Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 75 for “"intracellular signalling"”.
-
Intracellular signalling by arachidonic acid metabolites
In intrauterine tissues, pro-inflammatory cytokines and prostaglandins (PGs) have been identified as key mediators in the maintenance of pregnancy and parturition. The rise in PGD2 detected in the amniotic fluid before labour prompted the research presented in this thesis which describes the …
-
Novel Fluorescent Sensors for Dynamic Intracellular Signalling
Protein kinase C (PKC), comprised of ten isozymes, is an abundant regulator of cellular function. PKC activity in living cells is commonly assayed in in vitro experiments with cell lysate. Monitoring PKC activity in single living cells is not possible with such experiments. This thesis presents a …
-
Network approaches for data-driven reconstruction of intracellular signalling
Intra-cellular signalling determines how cells process information. Through the integration of diverse chemical and physical stimuli, cells can enact transcription, among other changes to modulate growth, fate and survival. It is through the dysregulation of such processes that many diseases, …
-
Novel intracellular signalling regulators of cartilage progenitor cell populations
Cartilage is a viscoelastic tissue that absorbs shocks and facilitates low friction of the joint. Adult articular cartilage is limited in its ability to self-repair. Lesions or gradual wear-and-tear affect cartilage integrity and lead to damage that, when untreated, can ultimately develop to …
-
Spatiotemporal modeling and model restructuration approaches in studies of intracellular signalling pathways
"The main focus of the research is to understand the complex phenomena of cell transduction pathways and cell biology in a single cell. Mathematical modeling and experimental evaluation are widely used approaches for this kind of research. Firstly, A multiscale framework for protein-protein …
-
Understanding the intracellular signalling pathways activated by lipid nanoparticle delivery of mRNA
… response and key triggers of innate immune signalling remain undefined. Therefore, the aim of this research was to investigate whether LNP/mRNA induces inflammation through Toll Like Receptors (TLRs) and whether endoplasmic reticulum (ER) stress is activated due to additional protein …
-
The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
Chronic IL-6 signalling contributes to the pathophysiology of many diseases including prostate cancer. Relevant to prostate cancer is the ability of the pro-inflammatory cytokine IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of …
-
Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins
… further elucidate the pathways involved in the intracellular signalling mechanisms of the 5-HT₂ₐ and related receptors. The Gprotein coupled receptors (GPCRs) are named after their ability to interact with and signal through the trimeric G-proteins. The 5-hydroxytryptamine 2A receptor (5- HT₂ₐR) …
-
Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart
… however, certain metabolic events and activation intracellular signalling events are known to trigger this cardioprotection. The purpose of this study was to investigate the metabolic and intracellular signalling events which occur during ischaemic preconditioning and their effects on improvement …
-
The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency
… Acute exercise stimulates a unique set of intracellular signalling cascades resulting in the activation of kinases which can subsequently control muscle metabolism. The signalling pathways involved are activated by alterations in ATP turnover, calcium flux, cellular stress and the redox …
-
T-lymphocyte senescence and hepatitis C virus infection
… relationship to clinical endpoints. Further, the intracellular signalling changes in T-lymphocytes with short telomeres were studied in subjects with chronic HCV. Short CD4+ T-lymphocyte telomeres were associated with the presence of severe hepatic fibrosis independent of other known factors. …
-
Measurement and mechanisms of complement-induced neutrophil dysfunction
… outcomes amongst critically ill adults. The intracellular signalling pathways which mediate C5a-induced neutrophil dysfunction are incompletely understood, and scalable tools with which to assess immune cell dysfunction in patients are lacking. This thesis aimed to develop tools with which to …
-
Prorenin, its maturation and the (pro)renin receptor
… of angiotensinogen and stimulation of an intracellular signalling pathway. The aim of this thesis is to investigate the biology of prorenin, its maturation and the (pro)renin receptor.
-
Molecular basis of Fce receptor: IgE interactions
… receptor FceRI. This interaction initiates intracellular signalling starting a cascade of events resulting in cellular degranulation and the release of inflammatory mediators. Many present treatments for these conditions act at this stage to inhibit the activity of these chemical …
-
Signalling mechanisms of the tyrosine phosphatase SHP2 upstream of Ras
… migration, and apoptosis. Dysregulation of intracellular signalling pathways, including Ras – mitogen activated protein kinase (MAPK), disrupts normal cell functioning and can lead to various disorders, including cancer and developmental pathologies. SHP2 regulates multiple signalling …
-
Mediators of monocyte activity in inflammation
… expression and adhesion to endothelial cells and intracellular peroxide formation, as end points. Monocytic intracellular signalling events were investigated after interaction of CRP with specific CRP receptors on monocytes. These initial signalling events were examined for their role in …
-
Interrogating the molecular mechanism of signal transduction in the TGF-β receptor superfamily
A major unanswered question in cellular signalling is how binding of an extracellular ligand to its cell-surface receptor triggers activation of an intracellular signalling cascade to achieve a physiological response. TGF-β signalling is central to many physiological processes, from embryonic …
-
Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… Despite being such a small family, their signalling is very diverse; each receptor responds to multiple endogenous agonists and couples to different G proteins, displaying pleiotropy. There is added variation in receptor desensitisation and internalisation, with intracellular signalling …
Page 1 of 4