Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 189 for “"intracellular signaling"”.
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Pressure-Induced Intracellular Signaling in Isolated Arteries
… mechanical stresses through the activation of intracellular signaling pathways which result in cell-specific responses such as hypertrophy, hyperplasia, proliferation, and migration. Vascular smooth muscle of the arteries have been shown to be sensitive to mechanical stimuli such as stretch, …
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An Evolutionary Computation Model of Intracellular Signaling Networks
… simulate the evolution of a particular class of intracellular signaling networks. This class of signaling networks mimics the cellular state transition (or mode switch) in a living cell in response to a specific number of prerequisites. Two different signaling regulations, namely absence receptor …
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Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction
… by extracellular signal-regulated kinase (ERK) signaling in the nucleus accumbens (NAc) shell or anterior cingulate cortex (PFC). ERK kinase inhibitor U0126 was infused in the NAc shell or PFC of Long Evans rats immediately prior to daily self-administration sessions and following 8+ days of …
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Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction
… experiments, we assessed the involvement of intracellular signaling pathways using molecular inhibitors. In order to interpret the results we developed two techniques that reliably clustered intermediate-sized datasets using principal component analysis and k-means clustering. Mechanical …
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Dissection of spatiotemporal intracellular signaling using engineered chemical and genetic tools
Cellular signaling proteins are responsible for transmitting intracellular signals and enacting the appropriate response to received stimuli. These messages are propagated through networks that rely on allosteric regulation, post-translational modifications, or other mechanisms for modulating …
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Intracellular signaling cascades in the dopaminergic specification of fetal mesencephalic neural progenitor cells.
… expanded fetal mouse NPCs, to investigate the signaling mechanisms involved in the differentiation of mouse fetal NPCs towards the dopaminergic phenotype and to compare short and long-term expanded NPCs. Long-term expanded fetal mesencephalic NPCs could be grown under suspension and adherent …
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Identification of Intracellular Signaling Pathways Regulated by the TAO Family of Mammalian STE20p Kinases
… for understanding important aspects of cell signaling. My research focused on determining physiological stimuli that activated TAO protein kinases and the consequence of this activation on downstream signaling. This approach, in conjunction with two-hybrid screening led to the elucidation of …
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Structural and Functional Studies of SLO K+ Channels: Mechanisms of Gating by Intracellular Signaling
… (SLO1, SLO2 and SLO3) provide a link between intracellular signaling and the electrical activity of a cell. The opening and closing (gating) of the three different SLO homologs is controlled by the synergistic action of membrane voltage and specific intracellular cues: Ca<sup>2+</sup> binding …
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Stochastic modeling of intracellular signaling dynamics for the purpose of regulating endothelial cell migration
… to regulating cell behaviors through control of intracellular signaling events is presented. Many cell behaviors are mediated by a network of intracellular protein activations that originate at the membrane in response to stimulation of cell surface receptors. Multiple protein signaling …
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Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
… serum IgE levels and eosinophilia. The exact intracellular signaling mechanisms used by IPD have not been identified and this research was designed to identify the pathways and second messengers, utilized by IPD, to facilitate its mode of action. Since IPD has been reported to inhibit cytokine …
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Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12
… stimulation may be a means of maintaining signaling activity over long periods of time The effect of depolarization on gene expression was determined. Gene expression profiling of PC12 cells over the course of 8 hours following a single or double pulse of stimulation confirmed that a …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
Activated islet specific T cells are central to the destructive autoimmune response observed in type 1 diabetes (T1D). Not surprisingly, intense focus is placed on understanding how autoreactive T cell responses arise and contribute to disease pathology in the hope of using this information to …
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Early Effects of Organophosphate Compounds on In Vitro Intracellular Signaling and Levels of Active Neurotrophin Receptors, and on In Vivo Neurotrophin Concentrations
… of neurotrophin receptors and their downstream signaling cascades are affected after exposure to OP compounds. We also characterized the molecular weight of a soluble factor responsible for inducing neurite outgrowth in vitro after in vivo exposure to a neuropathic OP compound. We evaluated in …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… which upon activation triggers a very complex intracellular signaling. Failures in these intracellular signals can lead to the loss of tolerance or to the development of deficient T lymphocytes. In this work, we attempt to address the role of two essential proteins in early TCR signaling, the …
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Extracellular microenvironment for the regulation of endothelial angiogenic responses
… signals on angiogenic responses and underlying intracellular signaling cascades in diabetic conditions. This lack of mechanistic understanding impedes technological advancement of new strategies for vascular tissue engineering therapies for DCM and diabetic ulcers.</p><p>The long-term goal of …
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Stochastic gene expression during lineage specification of single T helper lymphocytes
… of cell lineage specification governed by the signaling interplay between extracellular cues and intracellular transcriptional factors, where the strength of extracellular signaling dominates over the intracellular signaling components. In the presence of extracellular cues, T helper cells …
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Therapeutic potential of the anti-fibrotic drug Suberanilohydroxamic acid (SAHA) in canine corneal fibrosis
… Western blot was used to quantify isoforms of intracellular signaling proteins. Real-time PCR and zymography quantified matrix metalloproteinases (MMP) mRNA and protein expression, respectively. In study 2, a corneal alkali burn was created in Beagles using 1 N NaOH topically. Dogs were …
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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
… abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways affected in both degenerative and neoplastic disease states in liver include: insulin/IGF, Wnt/β-catenin, and …
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Quantitative cue-signal-response analysis of EGF-induced cell migration
… into the quantitative regulation of motility by intracellular signaling.
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Mapping And Characterization Of 18-5 And 12-5, Genes Which Potentially Link The Rhoa Signaling Pathway To The Ecdysone Response
Systemic steroid hormone and intracellular signaling pathways are known to act cooperatively during the development of vertebrate and invertebrate epithelia. However, the mechanism of this interaction is poorly understood. Morphogenesis of Drosophila leg imaginal disc epithelia is regulated both by …
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