Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"intracellular pathogens"”.
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DESIGNING BIOMIMETIC NANOPARTICLES TO TACKLE INTRACELLULAR PATHOGENS
… in modern medicine, certain bacterial pathogens such as Mycobacterium abscessus (Mab) continue to evade therapeutic clearance by creating intracellular reservoirs within host macrophages. Conventional drug delivery systems often fall short due to their lack of precision, limited …
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Investigating dynein-based transport of intracellular pathogens
… cellular cargoes, it can also be hijacked by pathogens that rely on intracellular transport for parts of their replicative cycle. This phenomenon is well exemplified by the obligate intracellular bacterium Orientia tsutsugamushi, which exploits dynein and microtubules to reach its subcellular …
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Identification of genes involved in macrophage activation and effector functions against intracellular pathogens
This dissertation addressed the hypothesis that macrophages have an alternative killing mechanism that is independent of superoxide and nitric oxide but dependent on IFN-γ, TNF and C/EBPβ. Since the mechanism and the genes involved in this alternative pathway are mostly unknown, the aim of this …
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Achieving protective immunitity against intracellular bacterial pathogens : a study on the efficiency of Gp96 as a vaccine carrier
Protective vaccination against intracellular pathogens using HSP fusion proteins in the listeria model.
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A role of statins against listeria monocytogenes and Mycobacterium tuberculosis infection
… role in the pathogenesis and persistence of intracellular pathogens. Here, we modulate host cholesterol biosynthesis pathway using pharmacological agent statins, which are reversible inhibitors of HMG†CoA reductase enzyme. The aim of the study was to investigate the role of statins in …
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Delineating The Roles of IL-12 and IL-23 Produced by Dendritic Cells in Eliciting CD8+ T Cell Resonses Against Listeria Monocytogenes
… IFN-γ production – key for clearance of intracellular pathogens. IL-23 promotes the development of IL-17 producing CD4+ T cells that participate in the control of extracellular pathogens and the induction of autoimmunity. These cytokines modulate T cell activation during primary …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are specified by both antigen recognition …
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Development of Core-Shell Polymeric Nanostructures for Delivery of Diagnostic and Chemotherapeutic Agents
… of such nanostructures in reduction of intracellular pathogens like Salmonella, Listeria, and Brucella were demonstrated. Current effort focuses on translation of this nano-drug delivery concept to in vivo model of intracellular infectious diseases. Atom transfer radical polymerization …
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Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
Intracellular pathogens are a major cause of global morbidity and mortality due to their complex and intricate ability to replicate within host cells while evading the innate immune defense system. Many intracellular pathogens, such as F. tularensis and B. pseudomallei, are highly infectious and …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
… (CTLs) play a critical role in controlling intracellular pathogens and cancer cells, and induction of memory CTLs holds promise for developing effective vaccines against critical virus infections. However, generating memory CTLs remains a major challenge for conventional vector-based, …
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Mycobacterium Tuberculosis Virulence Factor Mpt64 Targets the Endoplasmic Reticulum
… is one of the most successful human pathogens. One reason for its success is that M. tuberculosis can reside within host macrophages, a cell type that normally functions to phagocytose and destroy infectious bacteria. However, M. tuberculosis is able to evade macrophage defenses in …
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Functional Characterisation of the Mycobacterial Virulence Protein Erp
… tuberculosis, is among the most successful human pathogens. Throughout their complex life cycle in the host – infection, growth, transmission – mycobacteria must continually resist host defences. A major mycobacterial survival mechanism lies in the unusual and complex cell envelope. The …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
… are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of effector and memory cells, …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
… play a pivotal role in immune responses against intracellular pathogens, including viruses and bacteria, and in tumour surveillance. After encountering an antigen, CD8 T cells undergo cell growth, clonal expansion, and acquisition of effector functions. These steps are a result of controlled gene …
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An obligate intracellular bacterial pathogen forms extensive and stable interkingdom contacts with the endoplasmic reticulum
Intracellular pathogens employ various mechanisms to manipulate host membranes, a critical strategy for subverting host pathways and advancing their life cycle. To this end, Rickettsia parkeri directly engages the host plasma membrane to infiltrate target cells and spread to neighboring ones. …
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How TCR signal strength controls CTL polarisation for target killing
… cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide chain loaded into a major-histocompatability …
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Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
… CR3, a β₂ integrin, is a target for diverse intracellular pathogens, but its role in nonopsonic binding remains uncertain. We have examined the binding of M. tb. to human CR3 heterologously expressed in Chinese hamster ovary (CHO) cells, thereby circumventing the problems of competing …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
… adaptive immune system cell type responding to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) lymph nodes to the lung where they perform their cytolytic function. After pathogen clearance, …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… (Bm) and B. pseudomallei (Bpm) are facultative intracellular pathogens and the causative agents of glanders and melioidosis. At present, effective vaccines for the prevention of glanders, or melioidosis in humans, are not available. However, renewed attention has been directed toward developing …
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