Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"intracellular membranes"”.
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Variations in the Oxidative Rates of Nitrosomonas europaea in Coke-Plant Activated Sludge.
… upon the surface area of the peripheral intracellular membranes characteristic of Nitrosomonas. Nitrosomonas from the coke-plant mixed liquor and a pure culture of Nitrosomonas europaea increased the intracellular membrane surface area by increasing the number of intracellular membranes. …
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CELLULAR AND MOLECULAR PATHWAYS CONTROLLING SARS-COV2 ASSEMBLY AND EGRESS
… of Coronaviridae. Coronaviruses assemble on intracellular membranes, differently from many other RNA viruses that assemble and egress directly at the plasma membrane. This feature adds an additional layer of complexity to the study of the coronavirus life cycle as, once assembled, virions …
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Subcellular Localization and Activity of the Multidrug Resistance Protein 1
… and they include everything from decreasing intracellular drug concentrations to increasing rates drug metabolism. The study presented here focuses on the role of drug transporters in conferring drug resistance. MDR transporters are traditionally thought to extrude cytotoxins from the cell at …
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Mechanisms of Cell Surface Trafficking and Potential Functions of Extracellular Annexin A2
… in response to elevated concentrations of intracellular Ca2+. It is known that the binding of Ca2+ to the C-terminal Ca2+-binding domains is essential for the recruitment of AnxA2 to the inner leaflet of the plasma membrane. However, the mechanism by which AnxA2 is translocated from the …
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Identification and characterization of host genes involved in regulating replication of brome mosaic virus
… In particular, (+)RNA viruses use host intracellular membranes for their replication and lipid composition of these membranes is crucial for viral replication. I show here that BMV replication protein 1a causes redistribution of host Lam5 (Lipid transfer protein Anchored at a Membrane …
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Ryanodine receptors in calcium signaling pathways
… such as hormones and neurotransmitters to the intracellular system that carries out the cellular response to the stimulus. The universality of Ca<sup>2+</sup> as an intracellular messenger depends on its enormous versatility. This versatility is exploited to control processes as diverse as …
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Mutation of SLC7A14 Causes Syndromic Hearing Loss
… hearing loss. The SLC7A14 protein localized to intracellular membranes, including the endoplasmic reticulum, Golgi, and lysosomal both in vitro and in vivo. However, the missense mutant SLC7A14-p.(Gly330Arg) showed decreased lysosomal localization. SLC7A14-knockdown in vitro led to an increase …
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Investigation of the mechanism of transfer of a-tocopherol by the human a-tocopherol transfer protein (H-a-TTP) /
… of a-tocopherol, specifically its delivery to intracellular membranes by a-TTP, is still unclear and the molecular factors influencing transfer remain elusive. To investigate the mechanism of ligand transfer by the h-a-TTP, a fluorescent analogue of a-toc has been used in the development of a …
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Using Advanced Fluorescence Microscopy to Analyze Intracellular Trafficking of FcRn In Live Cells
The file named "GanZhou.pdf" is the primary dissertation file. All other files ("*.mov") are supplemental files and may be viewed individually.
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Biochemical and Genetic Studies of Beclin 1 Function in Autophagy
… cells. In degenerating pyramidal cells, there is intracellular protein accumulation that may have resulted from impaired autophagy, and activation of apoptotic pathway is also observed. In Purkinje cells, electron microscopy studies show a large number of aberrant electron dense structures and …
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Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An <i>in vitro</i> Study
… cell death pathways that originate from plasma membranes and/or intracellular membranes, especially mitochondria and endoplasmic reticulum. The specific aims are to: 1) determine whether nsPEFs induce cell death in E4 cells and Jurkat clones through caspase activation, 2) determine involvement …
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The role of the class III phosphoinositide 3-kinase VPS34 in regulatory T cells and activated CD8+ T cells
… is a mediator of endocytosis, trafficking of intracellular membranes and vesicles, and autophagy in various cell types. Given its central role in key cellbiological processes, we explored whether VPS34 is critical for immune cells by generating conditional knockout mice where exon 21 of Pik3c3 …
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Toward Quantitative Understanding of Compartmentalized NADPH Metabolism in Cancer Cells
… to be different due to its impermeability to intracellular membranes, yet it is known to be transported from one compartment to the other by various mechanisms such as metabolite shuttles. NADPH pool sizes can influence metabolic processes to a varying extent and targeting compartment-specific …
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Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
… reduced trafficking of cholera toxin B-labeled intracellular membranes to the plasma membrane. Cholera toxin-B labels the ganglioside GM1, which is enriched in lipid rafts. These specialized membrane domains are thought to serve as signaling hubs bearing many proteins that in turn, mediate …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… accumulates not only in the PM but also in the intracellular membranes of organelles, altering their membrane composition and functions. Organelles are dynamic, constantly interacting with each other and the PM through specialized membrane microdomains, known as membrane contact sites (MCS). MCS …
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
… infection induces the massive remodeling of intracellular membranes and the development of specialized domains harboring viral replication complexes, called replication organelles. The cellular protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) is …
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Asymmetrical transmembrane potential in intracellular organelles of adrenal chromaffin cells exposed to nanosecond electric pulses
… cells by creating nanopores in the cell and intracellular organelle membranes, making these membranes permeable to certain ions. A chromaffin cell contains, at a minimum, 7000 secretory granules plus other organelles such as mitochondria and the endoplasmic reticulum. In all the biological …
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Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans
… fluidity and permeability of fungal cell membranes. These include the azole antifungals, which block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of ‘toxic’ sterol intermediates are both thought …
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Novel In-Vitro Approaches to Investigate Membrane Partitioning and pH-Dependent Passive Permeation of Small Molecule Drugs
… of drug molecules through biological membranes is a fundamentally important process that involves the partitioning of molecules into the lipid bilayer membrane and passive permeation across the membrane. The majority of the drug molecules are either weak bases or acids. For these …
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