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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 183 for “"intracellular calcium"”.
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Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
It is well known that alterations in intracellular calcium, [Ca2]i, mobilization in the heart are among the major causes of cardiac dysfunction. To study the mechanism(s) involved in the development of diabetic cardio myopathy, [Ca2]i (determined by fluorescence microscopy and Ca-indicators) and …
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Studies on intracellular calcium pools in a pancreatic cell line
… 1,4,5-trisphosphate (IP₃) can release Ca²⁺ from intracellular stores, the phosphatidylinositol signal transduction system has been recognized as a major transduction pathway in most cell types. However, IP₃ is not the only intracellular Ca²⁺ mediator. In some cells, guanosine 5'-triphosphate …
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Intracellular Calcium Regulation and Changes in Ph in Molluscan Neurons
Made available in DSpace on 2014-12-14T05:40:44Z (GMT). No. of bitstreams: 1 8004119.pdf: 5835408 bytes, checksum: 900a3479f890eb5c5de309193cfc4784 (MD5) Previous issue date: 1979
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Analysing Mathematical Models of Intracellular Calcium Dynamics using Geometric Singular Perturbation Techniques
Oscillations in free intracellular calcium (Ca2+) concentration are known to act as signals in almost all cell types, transmitting messages which control cellular processes including muscle contraction, cellular secretion and neuronal firing. Due to the universal nature of calcium oscillations, …
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Modeling and Ion Mapping of Intracellular Calcium Distribution in Molluscan Neural Somata
… rapid (time constants of 1-3 sec) buffering of intracellular calcium in molluscan cell bodies, a diffusion-reaction model was developed. The model took into account the binding reactions of Ca('2+) with a calcium-indicating dye (arsenazo III) and an endogenous Ca('2+) buffer. The results from …
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The regulation of hypoxia-responsive gene expression by hydroxyl radicals and intracellular calcium
… was daraufhin deutet, dass intrazelluläres Calcium am O2-Signaltransduktionweg" beteiligt ist. Weiterhin wurde untersucht, inwieweit verschiedene Reagentien, die zu einem Anstieg oder einer Abnahme des intrazellulären Ca2+-Spiegels führen, die HIF-1a Proteinexpression beeinflussen. Dabei …
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Altered smooth muscle intracellular calcium signaling mechanisms in metabolic syndrome induced coronary artery disease
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
… of these diseases by modulating an unidentified Calcium-activated Chloride Channel (CaCC). Recent evidence indicates Ano1 to be the mediator of strong quintessential calcium-activated chloride current in several cell types. Ano1 is highly expressed in airway epithelium and downregulated in cystic …
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Intracellular Calcium and Protein Kinase C Regulate Nonspecific Cell-Mediated Cytotoxicity by Mouse Lymphocytes (Calmodulin)
… the use of various pharmacological agents. The calcium ionophore A23187 caused a marked increase in nonspecific cytotoxicity by mouse spleen lymphocytes against SV3T3 target cells. Using a standard ('51)Cr-release assay, little target cell death was seen prior to 16 hours of effector-target …
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Role of Intracellular Calcium Stores and Calcium-Permeable AMPARs in Functional and Structural Plasticity in Mouse Hippocampal Slices
… LTM and STM respectively. In both forms of LTP, calcium (Ca2+) signaling plays a vital role. However, Ca2+ has a number of different sources, the relative importance of which is poorly understood. Here I have investigated the role of calcium-permeable (CP)- AMPARs and Ca2+ release from …
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Investigating the clinical value of hyperactivation and intracellular calcium signalling of human spermatozoa and their value in drug screening
Confidential thesis. Abstract and full text under embargo until 12/03/2015.
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The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes
… and Nirmalan (2013), demonstrate that perturbed intracellular calcium handling and contractility can account for many aspects of myocardial depression. However, many of these studies suffer important limitations in that (A) small mammal models were used in which the translational relevance is …
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Cholinergic Regulation of Circadian Rhythms in the SCN: Characterization of Signaling Mechanisms and the Role of Intracellular Calcium in the Directionality of Clock Resetting
This study shows that stimulus-specific intracellular Ca2+ (Ca2+i) release controls the direction of clock resetting. Direct activation of the InsP3-induced Ca2+ i release (IICR) mimics cholinergic phase advance, while InsP3 , but not ryanodine, receptor antagonists block it. In contrast, selective …
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Direct Measurements of the Effects of Cyclic Adenosine Monophosphate, and Related Compounds, on Membrane Conductances, Intracellular Calcium and Ph in Gastropod Neurons (cyclic-Amp)
The dose-dependent effects of intracellular injections of cyclic adenosine monophosphate (AMP) and related compounds were examined in identifiable gastropod neurons. Injecting cyclic AMP (or cyclic GMP) in amounts which should have elevated the internal concentration from 0.1-7.6 mM (mean = 3.3 mM) …
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The effect of cis-5,8,11,14,17-eicosapentaenoic acid upon the contractile mechanisms linked to calcium influx and the mobilisation of intracellular calcium in aortic smooth muscle
… The latter effect was likely caused by reducing calcium influx through receptor-operated channels, supporting a recent suggestion by Asano et al (1997). Consistently, EPA decreased noradrenaline-induced contractures in aortic tissue, in support of previous reports (Engler, 1992b). The observed …
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The Role of Calcium in Signal Transduction: Kinetics and Regulation of Intracellular Calcium During the Photomechanical Response of the Albino Rat Sphincter Pupillae Smooth Muscle
Intracellular calcium regulates multiple processes in all cells, including contraction in myocytes. In smooth muscle the primary signal transduction cascade for agonist activation is receptor → G-protein → phospholipase C → inositol trisphosphate → intracellular calcium → …
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Identifying Potential Agonists Of TRPA1 Using A Heterologous Expression System And Transgenic Mice
… TRPA1. Using a fluorescent plate reader and the calcium-sensitive fluorescent dye FLUO-3AM, intracellular calcium levels of naive HEK and hTRPA1-HEK cells were monitored after exposure to a stimulus of interest. If a stimulus activated TRPA1, intracellular calcium levels increased resulting in …
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
… (RyRs) are large, endoplasmic reticulum (ER) intracellular calcium channels in excitable cells. RyRs are major cellular mediators of calcium-induced calcium release and crucial regulators of intracellular calcium homeostasis. Disruption of RyR function has been described in pathologies of …
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Higher order chromatin degradation induced by hydrogen peroxide in glial cells
… H2O2 concentrations as low as 50 muM. Chelating intracellular calcium with 1,2-bis( o-aminophenoxy)ethane-N,N,N',N' -tetraacetic acid tetra(acetoxymethyl) ester (BAPTA/AM) prior to H 2O2 exposure inhibited HOCD in a dose dependent manner. However, neither removing extracellular calcium, nor …
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