Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"intracellular bacteria"”.
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Development of vaccines against allergic asthma using products derived from intracellular bacteria or helminths
Die „Hygiene Hypothese“ postuliert, dass der Kontakt mit Infektionserregern in der frühen Kindheit die Entwicklung von Th2-abhängigen allergischen Immunreaktionen verhindern kann, indem dadurch entweder eine vorrangig Th1-gerichtete Immunität etabliert wird oder alternativ die Bildung von …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
… model.Efforts to target pathogenic bacteria that evade antibacterial drugs by inhabiting mammalian cells will be discussed. An unnatural proline-rich peptide Fl-P<sub> L</sub>P<sub>R</sub>P<sub>R</sub>-4 was developed with dual antibacterial and mammalian cell penetrating ability. …
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An investigation of the effects of an antimicrobial peptide on the survival of Acanthamoeba and intracellular bacteria associated with Cystic Fibrosis
… predominant candidates for combatting pathogenic bacteria. Free Living Amoebae is widely distributed in the environment and may also contaminate CF lung. It is well known that Acanthamoeba feed on and protect bacteria. The role of Acanthamoeba in CF lung infections has not yet been investigated. …
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Design, Synthesis and Characterization of Porous Silica Nanoparticles and Application in Intracellular Drug Delivery
… opportunities for targeting and killing of intracellular bacteria. Among them, the porous silica nanoparticles deserve special attention due to their multifunctional properties such as high drug loading, controlled drug release and targeting of organs/cells. A review of the functional …
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Identification of virulence determinants of Mycobacterium tuberculosis via genetic comparisons of a virulent and an attenuated strain of Mycobacterium tuberculosis.
… DNA technologies: two-dimensional bacterial genome display, and bacterial comparative genomic hybridisation. The two-dimensional technologies were optimised for mycobacterial use, but failed to yield reproducible genomic differences between the two strains. Expression differences …
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Adherence to and invasion of mammalian cell lines by Pasteurella multocida B:2
… of this disease is the rapid spread of infecting bacteria from the respiratory tract to the blood and lymph to cause a fatal septicemia. To pass into the blood stream, the bacteria must migrate through the epithelial layer into the pulmonary interstitium. Avian serogroup A strains of P. multocida …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Cooperative Electrostatic Polymer-Antibiotic Nanoplexes
Many pathogenic bacteria can enter phagocytic cells and replicate in them, and these intracellular bacteria are difficult to treat because the recommended antibiotics do not transport into the cells efficiently. Examples include food-borne bacteria such as Salmonella and Listeria as well as more …
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Identification and characterization of rickettsial proteins at the host-pathogen interface
Bacterial pathogens subvert host cell processes during infection by secreting protein effectors that manipulate host machinery. Cataloging such effectors has enabled a deeper exploration of the molecular basis of disease for numerous pathogens. Members of the Rickettsia genus are obligate …
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Novel Functions of ATG16L1 in the Innate Response to Invasive Bacterial Pathogens
… indicated that an inability to properly handle bacteria that come into contact with the intestinal mucosa, as well as defects in the regulation of the inflammatory response triggered by innate recognition of these bacteria, are primary factors in increasing CD susceptibility. Autophagy, a …
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The Activation of the Inflammasome during Rickettsial Infection
Rickettsiae are Gram-negative, obligately intracellular bacteria that infect endothelial cells and macrophages. The molecular mechanisms involved in interaction of rickettsiae with macrophages, however, remain poorly understood. In this dissertation, I have investigated the canonical and …
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Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
… CR3, a β₂ integrin, is a target for diverse intracellular pathogens, but its role in nonopsonic binding remains uncertain. We have examined the binding of M. tb. to human CR3 heterologously expressed in Chinese hamster ovary (CHO) cells, thereby circumventing the problems of competing …
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The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection
Intracellular bacterial pathogens secrete effectors to manipulate the host cell environment, create a hospitable niche, and promote infection. While many effectors interact with specific host machinery to perform a single distinct function, some effectors are capable of interaction with multiple …
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The tick response to Rickettsial dissemination during typical and atypical Rickettsial infection
… fever group (SFG) Rickettsia which are obligate intracellular bacteria belonging to the genus Rickettsia. In nature, ticks maintain the infection of SFG Rickettsia via vertical and horizontal transmission. However, the prevalence of rickettsial transmission is limited to certain species of ticks, …
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The cell-intrinsic innate immune response to DNA damage in human cells
… has evolved to detect DNA from viruses and intracellular bacteria and differentiate this from our almost identical self-DNA. DNA detected in the cytoplasm is thought to be identified as foreign due to its location, and bacterial DNA in endosomes in recognised by its hypomethylated motifs. …
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Jak-stat pathway in the control of mycobacterial infections
… in vivo functions of the JAK/STAT pathway in mycobacterial infection. Flies contain only one JAK (hop), one STAT (STAT92E), and three identified interleukin-like signals to activate signalling (upd, upd2, upd3).<br/>I show that, in Drosophila, the STAT-activating cytokine Upd3 is harmful to the …
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Mechanisms Involved in Enhanced Protection Against Gram Negative Bacterium Francisella tularensis Utilizing an FcR Targeted Vaccine Platform
<p>Francisella tularensis is a gram-negative intracellular bacterium and the etiologic factor of a potentially fatal disease tularemia. Due to its high infectivity the Centers for Disease Control and Prevention has designated F. tularensis as a Category A biological agent. Nevertheless, the …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
Salmonella enterica species are intracellular bacteria causative agents of gastroenteritis and typhoid fever in humans. Pregnancy poses an increased risk of severe Salmonellosis in many mammalian species contributing to miscarriage and/or maternal illness. Previous studies indicated that Salmonella …
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Role of extended spectrum beta lactamases producing E. coli and Acanthamoeba in urinary tract infections
… uncommon. It has been confirmed that pathogenic bacteria survive and multiply inside the protozoan parasite, Acanthamoeba. The indiscriminate use of various antimicrobial drugs has resulted in the development of drug resistance. Therefore, looking for new or additional antimicrobial compounds is …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… immune responses. TLR4 recognizes Gram-negative bacterial component LPS and initiates a series of intracellular NF-kappaB associated signaling events resulting in a cytokine response. We examined intracellular signaling events in human BECs leading to the production of IL-6, a major urinary …
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