Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"intestinal models"”.
-
Development of in vitro infant intestinal models to assess responses to infant formulae
Early postnatal nutrition and intestinal barrier maturation are intimately linked, with the neonatal gut characterized by higher permeability than in adults. The aim of this thesis was to develop and validate in vitro models that mimic the infant intestinal barrier. Once developed, these models …
-
Design, modeling, and validation of an apical flow Transwell insert for small intestinal models
… warming. Experimental validation of the flow models is done by tracking dye flow through the insert, and preliminary flow experiments appear to be in agreement with modeling results. The design, modeling, and experimental results discussed in this thesis present a promising step toward a …
-
Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
… atropine, 5-HT and its related drugs on intact intestinal segments taken from the ileum of adult and neonate rats. The application of ACh (3nM-1mM) and 5-HT (3nM-1mM) induced contractions in a concentration dependent manner in all tissues examined. The 5-HT induced contractions were only …
-
Multi-Scale Modelling of Host-Microbe Interactions: From Cell Membranes to Multi-Cellular Gut Models
Recently, the role of the intestinal tract in health and disease has become of increasing interest. Translation of conventional 2D in vitro and animal models, which have been the cornerstone for intestinal research, is however limited; while human studies are expensive and preclude individual …
-
Bioelectronic in vitro models for monitoring intestinal host-pathogen interactions
The human gastrointestinal tract is a highly complex, dynamic interface where host-microbe interactions not only underpin digestion and immunity but also disease pathogenesis. Studying this in vitro requires models that not only sufficiently recapitulate the physiological complexity of the barrier …
-
A 3D in vitro model of the human gut-microbiome. A bioelectronics approach.
… intricate cross-talk between the host and the intestinal flora remain a mystery. Until recently, the majority of studies that seek to explore these mechanisms relied almost exclusively on animal models, and particularly gnotobiotic mice. Despite the great progress made with these models, …