Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"intestinal inflammation"”.
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Epigenetic Memory of Mouse Intestinal Inflammation
… can cause regular injury. Fortunately, the small intestinal epithelium has a remarkable capacity to repair itself after severe injury, due to the abundance of highly replicative stem cells housed in the intestinal crypt regions. Much remains to be understood about the activation processes of the …
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Limiting host-microbiota interactions to control intestinal inflammation
The host intestinal tract lives in constant balance with the commensal microbiota residing in the intestinal lumen and immune responses must be tightly controlled. A strong intestinal barrier separates the immune system from resident microflora, and multiple mechanisms exist to reinforce the …
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Characterization of VIBRIO Parahaemolyticus-Induced Intestinal Inflammation in the Mouse
… wild type strain of V. parahaemolyticus exhibit intestinal inflammation characterized by epithelial damage, submucosal edema, crypt abscess and hyperplasia, and infiltration of the lamina propria by neutrophils. Using mutant strains of V. parahaemolyticus, we have determined that thermostable …
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Influence of intestinal inflammation on bacterial protein expression in monoassociated mice
Background: Increased numbers of intestinal E. coli are observed in inflammatory bowel disease, but the reasons for this proliferation and it exact role in intestinal inflammation are unknown. Aim of this PhD-project was to identify E. coli proteins involved in E. coli’s adaptation to the …
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Characterisation of the role of Fas in intestinal inflammation and cancer
… additional, non-apoptotic functions such as inflammation. Toll like Receptors (TLRs) play an important role in mediating inflammation and homeostasis in the intestine. Recent studies have shown that a level of crosstalk exists between the Fas and TLR signalling pathways but this has not yet …
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Investigating the role of IgG and Fcγ receptors in intestinal inflammation
… suggesting that IgG may be important during gut inflammation. IBD is a chronic relapsing condition with two major subtypes, Crohn’s disease (CD) and ulcerative colitis (UC), both driven by aberrant immune responses to commensals. In the first part of this thesis, we sought to investigate …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… chronic disease characterized by colonic inflammation, ulcers and erosion. Medications benefit 50% UC patients and have serious adverse effects. Therefore, safe and efficient molecules are needed as stan-alone drugs or in combination with available treatments to increase therapy potency …
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Characterizing the Role of the E. Coli Cytochrome Oxidase AppBCX During Intestinal Inflammation
… that is observed to outgrow during episodes of inflammation. In particular, we have studied the physiological function of the cytochrome bd oxidase, AppBCX. Using both chemical and genetic models of non-infectious colitis we have shown that it allows E. coli to utilize low levels of oxygen early …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
… of IBD, and how T-bet might influence inflammation in the gut. <br/>In this thesis it was shown that chronic IBD in TRUC mice was dependent on interleukin-17A (IL-17A) producing IL-7R+ CD90+ innate lymphoid cells (ILCs). Depletion of ILCs or IL-17A neutralization cured disease. …
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The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… Furthermore, it has become clear that the intestinal epithelial cell lining exerts an important role in the identification of bacteria and the appropriate counteraction. The involvement of the innate immune system can be explained by two theories. The first one states that an exaggerated …
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Intestinal Inflammation Model Inducing Gut Leakage by Different Methods in Broiler Chickens Using FITC-d as a Marker
… have been used in food animals to reduce enteric inflammation and maintain intestinal homeostasis, thus improving performance. Due to increasing restrictions regarding the use of AGP, precise and high throughput enteric inflammation models and markers to search for effective alternatives are …
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Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: Importance of peroxisome proliferator-activated receptor γ expression
… perpetuation of inflammatory responses. Since intestinal inflammation is a driving force in the development of colon cancer, in the present study, we investigated the suppression of dextran sodium sulfate (DSS)-induced colitis by dietary sphingomyelin in mice that lack functional peroxisome …
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Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… of the bowel, arising from the dysregulation of intestinal mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse develops intestinal inflammation with similar characteristics to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is …
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Colonocyte-Derived Lactate Promotes Enterobacteriaceae Fitness During Non-Infectious Colitis
… exchange of metabolites or resistance to gastrointestinal pathogens. In disease, however, the perturbation of these complex interactions can exacerbate pathogenesis. In this study, we examine the mechanisms promoting the disruption of normal host-microbe interactions after perturbances induced …
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Characterization of viral- and fungal-reactive CD4+ T cells in healthy and diseased
… contexts of SARS-CoV2 vaccination and chronic intestinal inflammation, with focus on the roles of pre-existing T cell repertoires, antigen specificity and cross reactivity. The first study demonstrates that the quality of immune responses to SARS-CoV-2-vaccination is strongly influenced by the …
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
Background: Several lines of evidence showed that inflammation is associated with changes in the expression of tachykinins both in human and animal models. Tachykinins, including substance P (SP), are small peptides expressed in the extrinsic primary afferent nerve fibres and enteric neurons of the …
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Investigating the Potential of Microbial Metabolites and mTOR Signaling on Chicken Necrotic Enteritis
… DCA alleviated the subclinical NE-induced intestinal inflammation compared to NE control birds. NE infection has significantly reduced overall bile acids in ileum content (7,638 vs. 2,530 nmol/g digesta). At the molecular level, the highest DCA dose at 1.5 g/kg reduced C. perfringens …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… animal models of IBD have demonstrated that intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may occur in intestinal inflammation, due to the organization of splanchnic circulation combined with local inflammatory damage. Therefore, …
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Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection
The intestinal epithelial barrier faces the arduous task of constantly monitoring and controlling the diverse bacteria which colonize the gut. Key for this balance are the Paneth cells, highly specialized secretory epithelial cells in the intestinal crypts which secrete anti-microbial peptides to …
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