Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 112 for “"intestinal epithelial cells"”.
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The intrinsic role of SOCS1 in intestinal epithelial cells
… cytokine signaling. To define its role in intestinal epithelial cells (IEC), our laboratory created a mouse model of Socs1 gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative colitis might be driven by …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… bodie's immune system is centred in the gastrointestinal tract (GI). Prolonged inflammatory conditions of the GI have been suggested to increase the risk for developing colon cancer. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4 are inflammatory mediators that can bind to four known …
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A novel function of enteropathogenic Escherichia coli secreted protein F within intestinal epithelial cells.
… Escherichia coli secreted protein F within intestinal epithelial cells.
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… proliferation, survival and migration of intestinal epithelial cells, whereas signaling through CysLT2R leads to differentiation of colorectal cancer cells. My main findings have been that 1) Leukotriene D4 (LTD4) induces intestinal epithelial cell proliferation by activating the mitogenic …
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Microbiota regulate short chain fatty acids and influence histone acylations in intestinal epithelial cells.
The intestinal microbiota have a vital role in aiding digestion by metabolising dietary fibres. In this process, they produce short chain fatty acids (SCFAs) such as butyrate, an important energy source for intestinal epithelial cells. SCFAs are chemically related to histone acylations, a growing …
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Regulation of mTORC1 Signalling and Amino Acid Uptake by Iron Availability in Caco-2 Intestinal Epithelial Cells
… was used to induce iron deficiency in Caco-2 cells (a cell line derived from a human colorectal carcinoma which has functional properties typical of absorptive enterocytes of the small intestine) in order to assess the effects of iron depletion on various aspects of the physiology of …
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A Study of the Ultrastructure of Intestinal Epithelial Cells of Piglets Infected With A Transmissible Gastroenteritis Virus
Made available in DSpace on 2014-12-09T22:30:16Z (GMT). No. of bitstreams: 1 6808258.pdf: 9970348 bytes, checksum: 4f58c9e66b11a16092233748c9591688 (MD5) Previous issue date: 1967
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Toxicological effects of metal oxide nanoparticles in combination with microbial components and inflammatory mediators on intestinal epithelial cells
… Research has shown that maintenance of epithelial barrier plays an important role in mucosal homeostasis. Intestinal epithelial cells (IECs) play a critical role in formation and maintenance of the intestinal epithelial barrier which functions as a protective barrier from microbial …
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The role of the rho-associated coiled-coil containing kinase (ROCK) in cytokine-induced chemokine responses in intestinal epithelial cells
… cytokine, IL-1β, induces chemokine expression in intestinal epithelial cells (IEC), which is mediated by Rho-associated kinase (ROCK). Because ROCK may be an important mediator of inflammation, we extended our investigations to examine the role of ROCK in TNF-α-stimulated chemokine responses in …
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Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
… growth phases to modulate macrophage and intestinal epithelial cell cytokine production following a pro-inflammatory challenge was examined. Modulation of cytokine production by human macrophage cell lines (U-937) and intestinal epithelial cells (HT-29) induced by Tumor Necrosis Factor α …
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Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… gene transcription and expression. While host intestinal epithelial cells (IECs) and antigen-presenting cells (APCs) can interact directly with both commensal and pathogenic bacteria through innate immune pattern recognition receptors, recent evidence indicates indirect communication mediated …
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A Study of the Golgi Response in Intestinal Epithelial Cells of the Rat During Fat Absorption as Revealed by Light and Electron Microscopy
Made available in DSpace on 2014-12-04T22:46:15Z (GMT). No. of bitstreams: 1 6104318.pdf: 3844078 bytes, checksum: d157a22c1d0a1163f7699144e788c137 (MD5) Previous issue date: 1961
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Interaction of peptides, peptidomimetics and other drug candidates with the DI/tripeptide transport system in intestinal epithelial cells, using the in vitro caco-2 cell culture system
An uptake system was developed using Caco-2 cell monolayers and the dipeptide, glycyl-[3H]L-proline, as a probe compound. Glycyl-[3H]L-proline uptake was via the di-/tripeptide transport system (DTS) and, exhibited concentration-, pH- and temperature-dependency. Dipeptides inhibited uptake of the …
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The invasin IbeA and its role in Adherent-Invasive Escherichia coli (AIEC) pathogenesis
… and its effect on AIEC adhesion and invasion of intestinal epithelial cells evaluated. The role that this outer membrane protein, IbeA, plays in intra-macrophage survival was also assessed. Compared to the wild-type, AIEC ∆ibeA presented reduced invasion to not only enterocytes but also M cells, …
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Effects of prebiotic fibre diets on rat mucosal intestinal and systemic immunity and in vitro mechanistic analysis of anti-inflammatory effects of lactobacillus strains on rat and human intestinal epithelial cells
… R0011 on innate immune parameters at the intestinal epithelial cell level, examining effects on both human and rat IEC. A second purpose was to define the effects of a range of prebiotic dietary fibres on the immune system at the mucosal and systemic level, using Biobreeding rats. L. …
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Human enteroids as a model for infectious disease
The human gastrointestinal (GI) tract is a major site of host-pathogen interactions. As such, many human pathogens have evolved to either use the GI tract as a portal of entry to gain access to distal sites in the body or cause acute disease within the GI tract. For many years we lacked a suitable …
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Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense
… protozoan parasite that infects the gastrointestinal epithelium, is a leading cause of infectious diarrhea and diarrheal-related death in young children worldwide and an opportunistic pathogen in immunocompromised individuals such as HIV/AIDS patients. There is no vaccine nor fully …
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OmpD but not OmpC is involved in adherence of Salmonella enterica serovar Typhimurium to human cells
… in adherence to human U937 macrophages and T84 intestinal epithelial cells. OmpC and ompD mutant strains were created by transposon mutagenesis utilizing P22-mediated transduction of Tn10 and Tn 5 insertions into wild-type strain 14028. Fluorescein-labeled wild-type and mutant bacteria were …
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