Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"intestinal epithelial cell"”.
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… are reported to beneficially affect the host intestinal immunity. However so far, the biological pathways modulated by these nutrients in intestinal inflammation at the level of intestinal epithelial layer (IEL) remains elusive. To bridge this knowledge gap, the aim of our present study was …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
<p>The intestinal epithelium is subjected to repetitive deformation during normal gut function by peristalsis and villous motility. In vitro, cyclic strain promotes intestinal epithelial proliferation and induces an absorptive phenotype characterized by increased dipeptidyl dipeptidase (DPPIV) …
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Intestinal Epithelial Cell Intrinsic IL-1R Signaling in Host Defense and Inflammation
Pages viii-xix are misnumbered as pages vi-xvii.
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The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
… and relapsing autoimmune disorder of the gastrointestinal tract that affects millions of people worldwide with incidence and prevalence on the rise. Increases in the rates of IBD have been partly attributed to shifts toward a western diet, which emphasizes calorie dense, nutrient poor foods high …
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Identifying dietary additive regulated mechanisms impacting intestinal epithelial cell responses and inflammatory processes
… in the development and management of gastrointestinal diseases like Inflammatory Bowel Disease (IBD). Dietary influences are now considered significant in determining an individual's susceptibility to IBD, yet much remains unknown about the long-term effects of various dietary components. …
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The investigation of microbial-intestinal epithelial cell interactions in the gut and their effects on inhibitor of apoptotic proteins (IAPs)
… assessed whether Lp299v prevents apoptosis in intestinal epithelial cells (IECs) when faced with cytokine challenge. Both in vitro and in vivo systems were exposed for a pre-determined time to Lp299v or strain Lpadh---a non-adherent derivative of Lp299v. HT-29 cells were then challenged with …
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
Background and aims: It has been reported that epithelial cells are involved in the process of inflammatory bowel disease (IBD) producing proinflammatory cytokines and chemokines. Glucocorticoids, being the most effective drugs for IBD patients, seem to have influence not only on the infiltrated …
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Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… resident bacteria opportunistically invade the intestinal barrier, leading to pathologies such as inflammatory bowel disease (IBD), and bacteremia. As a result, epithelial cell innate immune responses play an essential role in preventing bacterial invasion of host tissues and maintaining a …
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Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
… growth phases to modulate macrophage and intestinal epithelial cell cytokine production following a pro-inflammatory challenge was examined. Modulation of cytokine production by human macrophage cell lines (U-937) and intestinal epithelial cells (HT-29) induced by Tumor Necrosis Factor α …
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Negative Regulation of Inflammation: Implications for Inflammatory Bowel Disease and Colitis Associated Cancer
… signals is closely regulated by a plurality of cell signaling pathways, thereby maintaining homeostasis. In particular, the inflammatory signaling cascade contributes to cellular homeostasis and regulates responses prompted by external stimuli. Such responses are diverse and range from a variety …
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Human enteroids as a model for infectious disease
The human gastrointestinal (GI) tract is a major site of host-pathogen interactions. As such, many human pathogens have evolved to either use the GI tract as a portal of entry to gain access to distal sites in the body or cause acute disease within the GI tract. For many years we lacked a suitable …
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Intestinal Inflammatory Responses to the Indigenous Microbiota
… for inflammatory cytokines to sensitize intestinal epithelial cells to indigenous bacteria was evaluated in HT-29 cells associated with Lactobacillus plantarum 299v in the presence or absence of tumor necrosis factor-alpha (TNF-alpha). Co-culture of TNF-alpha-stimulated HT-29 cells with …
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Involvement of eicosanoid signalling in epithelial cell migration
… eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. In light of this, we have investigated the role of eicosanoids in cell migration a key process in IBD and CC. This was …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… proliferation, survival and migration of intestinal epithelial cells, whereas signaling through CysLT2R leads to differentiation of colorectal cancer cells. My main findings have been that 1) Leukotriene D4 (LTD4) induces intestinal epithelial cell proliferation by activating the mitogenic …
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Elucidating the biology of G-protein coupled receptor 35
… on ion homeostasis as well as affecting whole cell metabolism including glucose uptake, glycolysis and mitochondrial respiration. Using macrophages derived from CRISPR edited human induced pluripotent stem cells, we found the T108M PSC/UC risk associated coding polymorphism to be hypermorphic …
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Functional genomics of motile commensal intestinal bacteria
… of Lactobacillus ruminis, an autochthonous intestinal commensal, was studied. The flagellum-biogenesis genotypes of motile enteric Eubacterium and Roseburia species were also investigated. Flagellin proteins were recovered from these commensal species, their amino-termini were sequenced and …
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The Role of Surface Properties in the Transport of Folates Across the Intestine
The importance of the intestinal epithelial cell glycocalyx in the transport of folates in the intestine has been demonstrated. It was proposed that the glycocalyx acts as a retaining layer for the acid microclimate on the jejunal mucosal surface. Histological investigation of human jejunal …
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The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators
… studies underscore the importance of the damaged epithelial barrier and the dysregulated innate immune system in the pathogenesis of IBD. These two components cause defects in the interaction of the host with the bacterial flora. The epithelium must maintain a physical barrier between the lumen …
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Gastrointestinal Influences on Poliovirus Replication, Dissemination and Pathogenesis in Mice
… encounter a complex environment within the gastrointestinal (GI) tract, including pH changes, mucus, resident bacteria and a variety of epithelial and immune cell types. Little is known about how factors within and comprising the GI tract influence viral replication, dissemination and …
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The Role of MICRORNAs on Systemic and Central Nervous System- Inflammation in Aged Mice
… biological processes, including development, cell differentiation, proliferation, metabolism, and cell death. Aberrant regulation of microRNAs is seen in many diseases, such as sepsis, cardiovascular disease, neurological diseases such as stroke, and metabolic disorders. Because of their …
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