Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"intestinal epithelial barrier."”.
-
Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… investigations of the interactions between the intestinal epithelial barrier and the intracellular apicomplexan Eimeria spp., both in vivo and in vitro. Initially, conventional in vivo studies using genetically modified animals were used to investigate the contribution of innate lymphoid cells …
-
Toxicological effects of metal oxide nanoparticles in combination with microbial components and inflammatory mediators on intestinal epithelial cells
… Research has shown that maintenance of epithelial barrier plays an important role in mucosal homeostasis. Intestinal epithelial cells (IECs) play a critical role in formation and maintenance of the intestinal epithelial barrier which functions as a protective barrier from microbial …
-
The Role of Bacterial Amyloids In Regulating Gastrointestinal Homeostasis
… of the predominant phyla found in the host gastrointestinal microbiota in environmental biofilms. Curli fibers are the predominant microbial-associated molecular pattern (MAMP) on enteric bacteria recognized by the Toll-like receptor (TLR) 2/1-heterodimer complex. Interestingly, the TLR2/1 complex …
-
Neutrophil Regulation of Colitis
The delicate intestinal homeostasis is regulated by interactions between microbiota, intestinal epithelial cells (IECs), and the intestinal immune system. As a crucial component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial …
-
Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… which are required for the killing of human intestinal epithelial cells (Chapter-I) by this cytokine combination. A human kinome RNAi screen and a drug repurposing screen identified the Janus kinases (JAKs) JAK1 and JAK2 as the major kinases required for IFN-γ + TNF-α dependent synergistic …
-
The impact of microgravity conditions on human gut microbiome
… the precise effects of microgravity on intestinal physiology and microbial interactions remain largely unexplored. This PhD thesis investigates the impact of microgravity on the human gut microbiome through in vitro experiments, focusing on the intestinal epithelial barrier as a key …
-
Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
The intestinal tissue is charged with a delicate immunological task. The intestinal immune system needs to be tolerant towards nutrients and microbiota present in the intestinal lumen, while simultaneously detecting and responding to dangers such as pathogens. A single-cell layer of intestinal …
-
Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection
The intestinal epithelial barrier faces the arduous task of constantly monitoring and controlling the diverse bacteria which colonize the gut. Key for this balance are the Paneth cells, highly specialized secretory epithelial cells in the intestinal crypts which secrete anti-microbial peptides to …
-
The Tissue Specific Role of Endosome Associated Protein SNX27 in Colonic Inflammation and Tumorigenesis
… in the intestines and the development of intestinal disorders remains to be unexplored. Epithelial barrier integrity, regulated by junction proteins, is critical for the maintenance of intestinal tissue homeostasis. Weakening of the intestinal barrier thus promotes susceptibility towards …
-
Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and pro-inflammatory signals. Intestinal epithelial barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic …
-
Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and pro-inflammatory signals. Intestinal epithelial barrier, commensal bacteria, and immune cells, along with the interactions between the three players maintain a toleranic …
-
Caracterização da microbiota intestinal, perfil inflamatório e integridade da barreira gastrointestinal de crianças diagnosticadas com transtorno do espectro autista
… in this population or its relationship with intestinal epithelial barrier composition, behavior, and food preferences.Objective: To characterize the gut microbiota and its antimicrobial resistance genes (ARG), as well as to evaluate the eating behavior of children with ASD. Methodology: A …
-
Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… Crohn’s disease, are characterized by increased intestinal permeability caused by intestinal mucosal barrier dysfunction, a critical factor in the pathogenesis of IBD. The immune system is the major effector of this tissue damage, through the action of multiple cell types as well as soluble …
-
IMMUNOMODULATION AND INTESTINAL BARRIER PROTECTION ACTIVITIES OF A NOVEL SYNTHETIC GLUCOSE ANALOGUE IN INFLAMMATORY ANIMAL MODEL OF COLITIS AND ASTHMA.
The mucosal surfaces of the gastrointestinal and respiratory tracts are the main interfaces between the environment and the host. All two are protected by continuous epithelia that prevents the entry of microbes and integrity loss of these epithelia commonly predispose to infection. On the other …