Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"intestinal crypt"”.
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Behavioral and genetic characteristics of intestinal cell lineages in health and disease
The intestinal crypt is a highly dynamic system, as the entire epithelium is constantly turned over and renewed by the proliferative stem cells located at the bottom of the crypt. While this system is crucial for nutrient absorption, any derangements in the proliferative cells can quickly lead to …
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Epigenetic Memory of Mouse Intestinal Inflammation
… can cause regular injury. Fortunately, the small intestinal epithelium has a remarkable capacity to repair itself after severe injury, due to the abundance of highly replicative stem cells housed in the intestinal crypt regions. Much remains to be understood about the activation processes of the …
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Spatiotemporal dynamics of cell division in intestinal homeostasis
Intestinal homeostasis is governed by fate choices of stem cells residing in the intestinal crypt base. This must involve niche-specific co-ordination of cell division to guarantee that epithelial cells divide at the right time and place. These mechanisms operate to ensure precise control of the …
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Selective irradiation of the vascular endothelium
… between vascular endothelial cell apoptosis and intestinal crypt stem cell death was evaluated using uniform whole-body and selective vascular irradiation techniques. Mice received whole-body epithermal neutron beam irradiation. Additional dose was selectively targeted to endothelial cells from …
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Effects of dietary enzyme supplementation on performance, bone ash, small intestinal morphology, and apparent ileal amino acid digestibility of broilers exposed to a live coccidia oocyst vaccine
… reduced (P ≤ 0.05) IAAD in EXP 3. Small intestinal morphology and goblet cell numbers were affected by enzyme supplementation and vaccination, which resulted in significant (P ≤ 0.05) interactions. In general, vaccination increased (P ≤ 0.05) small intestinal crypt depth and reduced (P ≤ …
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The Ligand and Function of the RegIII Family of Bactericidal C-Type Lectins
… microbes must be prevented from crossing the intestinal epithelium into host tissues where they can cause inflammation and sepsis. The innate immune system plays a crucial role in preventing bacterial incursions across gut epithelial surfaces. Mucosal epithelial cells produce a variety of …
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Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
The intestinal epithelium is rapidly renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation of these dynamics through oncogenic mutation can predispose the epithelium to …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
Obesity is linked to increased intestinal permeability that may contribute to low grade inflammation. Fructan prebiotics have been demonstrated to increase intestinal resistance and decrease systemic inflammation. The objective of this study was to test the effects of prebiotics on intestinal …
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Impaired ketogenesis is implicated in intestinal stem cell function and epithelial regeneration in ulcerative colitis
… to mucosal healing in Ulcerative Colitis (UC). Intestinal stem cells (ISCs) drive this response, proliferating and differentiating from the base of the crypt to regenerate the entire epithelium. ISCs therefore exist in a highly active state and resultantly are vulnerable to changes in energy …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… cell line MCF10A and from primary mouse intestinal crypt and mammary gland epithelial cells. These cells are dependent on EGFR signaling for their growth and differentiation in Matrigel. Our data showed that treatment with compounds that inhibit EGFR-NCE increase growth of mice intestinal …
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Role of the LPA2 Receptor in Protecting Against Apoptosis
… (LPA) as a potent antiapoptotic agent for the intestinal epithelium. Based on computational modeling octadecenyl thiophosphate (OTP) was synthesized: a novel rationally designed, metabolically stabilized LPA mimic. OTP was more efficacious than LPA in reducing g-irradiation-, camptothecin-, or …
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Mutational processes in normal human tissues
… tissues of adult mammals. The base of each small intestinal crypt is occupied by stem cells and the descendants of a single recent ancestor stem cell comprise most cells in each crypt. Therefore, isolation of single crypts provides relatively homogeneous clones of cells from which somatic …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… is to propose a novel model to understanding intestinal homeostasis in the face of various disturbance events. Chapter 2 investigated the effects of Runting Stunting Syndrome on broiler chickens in four different groups of chicks displaying clinical symptoms. The major finding in this study …
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Delayed access to feed affects broiler small intestinal morphology and intestinal cell ontogeny
… to feed (DAF) has been found to inhibit small intestinal development, compromising growth of the chick. To further understand the impact of DAF on small intestines at the molecular level, many developmental genes that regulate intestinal development were investigated. The objective of this …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… this I have conditionally deleted c-Myc from the intestinal epithelium and examined the response of intestinal enterocytes following DNA damage. Remarkably, following DNA damage, c-Myc deficient enterocytes were unable to upregulate p53 and induce apoptosis, which was mechanistically due to an …