Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"intestinal barrier function"”.
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INTERACTIVE EFFECT OF DIETARY FIBRE AND IMMUNE CHALLENGE ON THREONINE REQUIREMENT AND INTESTINAL BARRIER FUNCTION IN GROWING PIGS
… (Thr) may also play an important role in intestinal barrier function. Therefore, this thesis evaluated the independent and combined effects of high DF and immune challenge [Salmonella typhimurium and systemic E. coli lipopolysaccharide (LPS)] on the Thr requirement for PD and growth in …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
Obesity is linked to increased intestinal permeability that may contribute to low grade inflammation. Fructan prebiotics have been demonstrated to increase intestinal resistance and decrease systemic inflammation. The objective of this study was to test the effects of prebiotics on intestinal …
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¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿
… by dysregulated inflammation and impaired intestinal barrier function. Although effective, current therapies present limitations, highlighting the need for complementary approaches. Chios Mastic Gum (CMG), a resin from Pistacia lentiscus, has shown anti-inflammatory and barrier-protective …
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
Dysfunction of the gut-liver axis contributes to non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression. Bile acid homeostasis is disrupted in NAFLD, and this has been suggested to increase cytotoxic bile acids species in the intestine, disrupt cytoprotective intestinal bile acid …
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… that ethanol increases both pulmonary and gastrointestinal inflammation as well as susceptibility to infection in burn-injured mice; however, the mechanisms of these responses are not entirely known. Moreover, after burn injury, bacteria and their products leak out of the intestinal lumen and …
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Design and evaluation of an instrumented microfluidic organotypic device and sensor module for organ-on-a-chip applications
… Organ-on-chip devices recapitulate some tissue functions and are useful for high-throughput screening but fail to capture the richness of cellular interactions of tissues in vivo because they lack the cellular diversity and complex architecture of native tissue. This thesis describes the design …
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Influences of milk intake and dietary inclusion of a bioactive extract from the olive (Olea europaea) on glucagon-like peptide-2 and its effects on growth and intestinal health of dairy calves
Promotion of intestinal health in preruminant dairy calves is essential for growth and overall health. Yet, a large proportion of dairy calves in the United States is affected by enteric challenges in the preweaning period. Maintenance of intestinal integrity is associated with an intestinal …
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The gut microbiome: A key regulator of mucosal tolerance, barrier function, and vaccine response
In multicellular organisms, the gastrointestinal tract serves as the largest interface between the internal body and the external environment. In mammals, the gastrointestinal (GI) tract intestine is home to a diverse and dynamic microbial community, continuously exposing the mucosal epithelium to …
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Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
… Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest surface to the outside environment; it performs diverse and complex roles in an ever changing external environment. It has evolved into a fine tuned sensory organ, with a complex …
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Impact of dietary functional yeast additives on growth performance and health of selected key aquaculture species
… impacts and managing disease prevalence. Functional feed additives (FFAs) have emerged as sustainable solutions to enhance fish health and performance. Among these, yeast-derived additives have garnered significant attention for their nutritional benefits and proven ability to promote …
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Investigating the role of the gut microbiota on immune checkpoint inhibitor-mediated colitis
… may impact on irAEs. Considering that the gastrointestinal tract harbors thousands of unique microbial species, many of which are known to modulate the immune system, microbes and microbe-derived factors are likely important modulators of IMC risk and severity.</p> <p>In two related studies, we …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… health, including cardiometabolic regulation, intestinal function, and healthy aging. In particular, dietary (poly)phenols and xanthines have gained attention for their potential benefits on several metabolic and functional biomarkers. However, the mechanisms are not completely understood and …
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Study of apoptotic deletion mediated by Bifidobacterium longum with construction of recombinant strains for Serpin encoding gene and phenotypes comparison in a pig cell model
… for strains with the abilities to colonize the intestinal mucosa and with good adhesion capacities, so that we can test these strains to investigate their ability to induce apoptosis in “damaged” intestinal cells. Adhesion and apoptosis are the two process that we want to study to better …