Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"intervertebral discs"”.
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
Intervertebral disc degeneration has been identified as a main cause for low back pain, a large health problem in the Western world today with 60%-80% of people affected at some point during their lives. Current treatments alleviate the symptoms rather than repair the tissue, but tissue engineering …
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Mechanisms for regenerative intervertebral disc healing during early growth in mice
<p>Annulus Fibrosus (AF) defects of intervertebral discs (IVDs) cause painful disability, for example when herniated tissue compresses against adjacent nerves. Discectomy, the current standard of treatment to address herniation, does not repair AF defects and can result in re-herniation and …
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
Intervertebral discs (IVDs) are unique musculoskeletal tissues within functional spinal unit organs comprising the spinal column that distribute loads and allow complex movements for vertebrates. IVD degeneration has been closely associated with manifestations of symptomatic IVD disease (IVDD). …
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Effects of high intensity focused ultrasound on the intervertebral disc
… intensity focused ultrasound treatment of the intervertebral disc. We demonstrated that it was possible to heat intervertebral discs with HIFU delivered by 50 or 5 mm diameter ultrasound transducers. Finite element studies indicated that it would be possible to heat the disc to a temperature of …
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Mechanics of biomimetic materials for tissue engineering of the intervertebral disc
… shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments that disrupt the biomechanics of the spine. New materials, which exhibit sophisticated mechanical responses, are needed to provide templates for …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
Intervertebral discs (IVDs) are the cartilaginous structures in the spine that connect adjacent vertebrae, absorb shock from daily activities, and allow for articulation of the spine. Unfortunately, IVDs are prone to degeneration and have little to no capacity for self-repair. IVD degeneration is …
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A Computer Simulation Model of The Human Head-Neck Musculoskeletal System
… Nastran 4D. Interconnecting joints, including intervertebral discs, facet joints, ligaments, and the C0-C1-C2 complex, were defined. The primary neck muscles for axial rotation, lateral bending, extension, and flexion movements were defined, respectively. For each specific movement, the model …
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Creation and Validation of a Dynamic, EMG-Driven Cervical Spine Model
… created in MSC Adams™ and included vertebrae, intervertebral discs, ligaments, and muscles. The vertebrae (C1-C7) were harvested from a cadaver, and using a white light scanner, were turned into 3D models. The discs were modeled as bushing forces. The ligaments were modeled as single vector …
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A patient specific total disc replacement to treat degenerative disc disease
… most often arising from degeneration of the intervertebral discs (IVD). When conservative treatments fail, surgical replacement with an artificial total disc replacement (TDR) is often required. However, despite decades of refinement, current TDRs are unable to fully replicate the complex …
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Development of Dendritic Polymers as a Modular Drug Delivery Platform for Avascular Tissues
… tissues, such as articular cartilage, meniscus, intervertebral discs, and cornea stroma, pose a number of challenges for disease treatment. Systemic therapies will not reach the target tissue at efficacious levels. Local therapies are rapidly cleared from the tissue due to turnover of biological …
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Verification of the <i>Ex Vivo</i> Thiel Embalmed Model for Liver Treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS) before Clinical Practice
… temperatures achieved in the vertebrae and the intervertebral discs could achieve coagulative necrosis.<br/><br/>The technologies and the research described in this thesis have been shown to overcome many of the present limitation and should therefore be useful for ongoing pre-clinical research …
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Modelizado y optimización de problemas biomecánicos mediante la combinación del método de los elementos finitos (mef) y técnicas avanzadas de optimización
… optimisation of the biomechanical behaviour of intervertebral discs (DIV) in lumbar functional spinal units (FSU), with the aim of obtaining the most appropriate parameters that define the biomechanical behaviour of the FE models. The advantage of the combined use of FEM and MRS, as proposed in …
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Polymer Composite Spinal Disc Implants
… annulus fibrosus similar to that of the natural intervertebral disc, as well as find preliminary results for vertebral endplate connection and nucleus pulposus internal pressure, for the correction of disc degeneration in the spine. The three-part composite samples needed to demonstrate good …