Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"interstrand crosslinks (ICLs)"”.
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Elucidation of Snm1B Function
… Snm1B protects DNA from agents that induce interstrand crosslinks (ICLs), lethal lesions that covalently attach the opposite strands of DNA together. To elucidate how Snm1B performs these functions I performed a yeast two-hybrid screen to identify proteins binding to the C-terminus of Snm1B. …
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Understanding of Intrinsic Sources of DNA Damage that Drive Human Disease: A Foray into the Study of DNA Interstrand Crosslinks and Genome-Embedded Ribonucleotides
… focus on two types of endogenous DNA damage: 1) interstrand crosslinks (ICLs) formed by DNA damaging aldehydes and 2) genome-embedded ribonucleotides. The clinical pathologies arising in the setting of the improper removal or repair of ICLs or genome-embedded ribonucleotides are diverse. A …
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Modulated Functions of The Fanconi Anemia Core Complex
… are characterized by hypersensitivity to DNA interstrand crosslinks (ICLs), suggesting that FA genes play a role in ICL repair. Fanconi anemia core complex (including A, B, C, E, F, G, L, FAAP20, and FAAP100) activates the Fanconi pathway by providing the essential E3 ligase activity for …
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Investigating the role of protein ubiquitylation in the maintenance of genome stability
… step in the repair of other DNA lesions, such as interstrand crosslinks (ICLs). The importance of HR for maintaining genome stability is underscored by the observation that loss-of-function mutations in HR factors are commonly seen in human cancers. In this thesis, I report the use of a key …
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Regulation of structure-selective nucleases by the SLX4 scaffold in ICL repair and HJ resolution
… shown to have essential roles in repair of DNA interstrand crosslinks (ICLs). In addition to its role in ICL repair, the SLX4 complex has the relatively unusual property of being able to cleave efficiently four-way DNA structures called Holliday junctions (HJs) in vitro. At the outset of this …
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… (FANC) proteins involved in the repair of DNA interstrand crosslinks (ICLs). More recently, two DNA glycosylases (endonuclease VIII – like 1 & 3 [NEIL1 & NEIL3]) that excise oxidised bases from DNA, thus initiating base excision repair, have been found to participate in the resolution of …
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Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin
… where it produces DNA intra- and inter-strand crosslinks that prevent transcription and DNA replication to cause cell death. Although numerous mechanisms of tumour resistance to oxaliplatin have been reported, normal healthy cells also rely on the majority of these mechanisms for survival and …
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Structural and Biochemical Investigation of Fanconi Anemia Pathway Activation
DNA interstrand-crosslinks (ICLs) are covalent links between complementary DNA strands that prevent their separation, interfering with fundamental cellular processes such as DNA replication and transcription. Consequently, these DNA lesions are highly toxic and the inability to repair them results …
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… two major threats to genomic stability: DNA interstrand crosslinks (ICLs), and the expansion of trinucleotide repeats. ICLs are highly deleterious lesions that disrupt replication, are destructive to dividing cells, and are extremely toxic to the hematopoietic system. The …
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Caretaker-Gen-Syndrome
… sich durch Hypersensitivität gegenüber DNA-„interstrand crosslinks“ (ICLs) aus, zu deren Behebung u.a. die homologe Rekombinationsreparatur (HRR) eingesetzt wird, bei der das RAD51(A)-Protein eine zentrale Rolle spielt. Aufgrund schwacher Homologien werden 5 weitere Proteine (RAD51B, C, D, …