Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"interstitial fluid flow"”.
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Interstitial Fluid Flow Magnitude and Its Effects on Glioblastoma Invasion
Fluid flow is a complex and dynamic process in the brain, taking place at the macro- and microscopic level. Interstitial fluid in particular flows throughout the interstitial spaces within the tissue, interacting with cells and the extracellular matrix. We are coming to find that this interstitial …
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Effect of Interstitial Fluid Flow and Radiotherapy on Glioblastoma Invasiveness and Progression
… extensively, its effect on the transport of fluid is not well characterized. Transport in the brain which has significant roles in physiology, GBM pathophysiology, and GBM treatment. Thus, understanding the effect of radiation on transport within the lesion and surrounding interstitium will …
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The Role of Interstitial Fluid Flow in the Progression of Glioblastoma and Alzheimer's Disease
… conditions are characterized by a disruption in interstitial fluid flow (IFF) and an increase in neuroinflammation. Throughout the following dissertation, we examined the role of IFF in AD and GBM progression using a three-sided approach (in vivo, in vitro, and in silico). Increased IFF underlies …
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… activation in breast cancer cells in response to interstitial fluid flow. Additionally, we explored the involvement of AMPK in breast cancer cell migration. An in-vitro three-dimensional (3D) cell culture model utilizing collagen-Matrigel matrices was used. Interstitial fluid flow was applied to …
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The effect of the interstitial flow on the directional cell migration and sprouting of capillaries
… project focuses specifically on the effect of interstitial fluid flow on the capillary morphogenesis process. Interstitial fluid flow is defined as flow perpendicular to the endothelial monolayer, as opposed to shear flow which is parallel. Interstitial flow is an essential process in vivo both …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… progression and how stromal elements impact interstitial fluid dynamics. This dissertation examines dual aspects of this complexity: first, by elucidating the specific contributions of Fusobacterium nucleatum (F. nucleatum) to pancreatic cancer pathogenesis and developing a novel therapeutic …
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On-Chip Engineered Human Lymphatic Microvasculature for Physio-/Pathological Transport Phenomena Studies
… lymphatic structure and function, within a microfluidic system that allows for high spatial-temporal control over the biological transport phenomena to study cellular events. For the first part in this thesis, we implemented a microfluidic-based cell culture system to screen for the optimal …
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Effects of blood vessel permeability on mechanical properties of bone under micro-gravity conditions
… permeability to increase the transcortical interstitial fluid flow. A method of exposure to bio-frequency spectrum (BFS) light (infrared to micrometer wavelength) was used to increase the blood vessel permeability. We tested the hypothesis by examining the bone mechanical properties (Young's …
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Targeting S1PR3 to mitigate flow-enhanced invasion in the glioblastoma tumor microenvironment
… Emerging evidence has implicated pathological interstitial fluid flow, created by high intratumoral pressure relative to the healthy parenchyma, in enhancing cancer invasion. Multiple targetable molecular pathways have been identified that drive this response, but the specific pathways employed …
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A three constituent mixture theory model of cutaneous and subcutaneous tissue in the context of neonatal pressure ulcer etiology and prevention
<p>Localized ischemia, impaired interstitial fluid flow, and sustained mechanical loading of cells have all been hypothesized as mechanisms of pressure ulcer (PrU) etiology. Time-varying loading has experimentally been shown to increase fluid flow in human skin <em>in vivo.</em> Towards the design …
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Effects of Estrogen Loss on the Vascular Porosity in Rat Cortical Bone
… which is important for bone health; load-induced interstitial fluid flow within the lacunar-canalicular porosity surrounding osteocytes is thought to play an important role in bone maintenance, while the vascular porosity provides a pressure relaxation mechanism for the fluid flow in the …
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The role of mechanical loading in chondrocyte signaling pathways
… by high (>10 μl/min) and moderate (5 μl/min) interstitial fluid flow, respectively, but KRas-FAK did not respond to the flow. We also found that Src activation by loading was blocked by inhibition of FAK, while inhibition of Src did not affect FAK activities, suggesting that FAK is necessary …
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Advancing Dynamic Imaging for Microfluidic Stimulated Tissues: Biology, Techniques, and Applications
… in intact tissues stimulated in a microfluidic device creates opportunities for studying major diseases such as diabetes and cancer. Despite a number of documented phenotypic traits of these diseases, the underlying pathophysiological mechanisms remain to be elucidated. Conventional …
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Numerical Study of Nutrient Mixing in Trabecular Bone in Microgravity, Disuse and Normogravity
… is known to regulate bone remodeling by driving interstitial fluid flow which stimulates cells and drives nutrient transport within the trabecular network. In microgravity, the absence of mechanical stimulation or loading suppresses convective flow processes, causing diffusion-driven nutrient …
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Examining location-specific invasive patterns: linking interstitial fluid and vasculature in glioblastoma
… therapies. Thus, tumor recurrence is inevitable. Interstitial fluid surrounds all of the cells in the body and has been linked to elevated invasion in glioma, which highlights the importance of this understudied fluid compartment in the brain. The primary objective of this dissertation was to …
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The convective desalination of sea ice
… of sea-ice growth but also of its internal fluid dynamics. This thesis considers a class of physical systems called mushy layers, of which sea ice is an example. Mushy layers are multi-component systems consisting of a porous matrix of solid phase whose interstices contain the same substance …
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Using Mechanical Interventions To Enhance Drug Transport To Bone Tumors
… in the tumor microenvironment and elevated interstitial fluid pressure, tissue penetration of therapeutic agents is often more limited in cancerous tumors compared to normal tissue. Weight-bearing mechanical loading applied to bone, as well as other mechanical stimulations such as vibration, …
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The Interplay Between Bone Homeostasis, Permeability, and Fracture Toughness
… these cells and forms a porous system allowing fluid to flow through interconnected spaces. This interstitial fluid movement enables nutrient delivery, cell signaling, and mechanosensation, which regulate bone remodeling and adaptation to mechanical demands. Bone’s ability to maintain structure, …
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Engineered models of the lymphatic stroma to study cell and fluid transport
… system plays essential roles in regulating fluid balance and immunosurveillance. Across the body, local lymphatic vessels collect waste in the form of lymph and deliver it to nearby lymph nodes (LNs) to be filtered and screened for pathogens. With broad implications in adaptive immunity, …
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Numerical modeling of cortical bone adaptation due to mechanical loading using the finite element method
… as a poroelastic material to account for the interstitial fluid flow. We aim to develop a growth stimulus similar to strain energy density for the poroelastic material model. In order to achieve this goal, we develop the FE model of a rectangular beam subjected to pure bending. This geometric …
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