Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"interstitial fluid"”.
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Interstitial Fluid Flow Magnitude and Its Effects on Glioblastoma Invasion
Fluid flow is a complex and dynamic process in the brain, taking place at the macro- and microscopic level. Interstitial fluid in particular flows throughout the interstitial spaces within the tissue, interacting with cells and the extracellular matrix. We are coming to find that this interstitial …
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Mechanotransduction of interstitial fluid stresses and effects on tumor cell migration
… the extracellular matrix (ECM) drive flow of interstitial fluid through the ECM. Elevated osmotic pressure, lymphatic collapse, solid stress, and increased microvascular permeability contribute to elevated interstitial fluid pressure (IFP) during carcinoma progression, and high intratumoral …
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Monitoring and control of the accumulation of interstitial fluid in the legs
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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Needle-free interstitial fluid acquisition using a Lorentz-force actuated jet injector
Interstitial fluid (ISF) provides information on a patient's health as it contains regulatory molecules that are correlated with disease-related processes. However, current ISF acquisition techniques can be slow, resulting in patient discomfort and erroneous measurements. This thesis presents a …
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Effect of Interstitial Fluid Flow and Radiotherapy on Glioblastoma Invasiveness and Progression
… extensively, its effect on the transport of fluid is not well characterized. Transport in the brain which has significant roles in physiology, GBM pathophysiology, and GBM treatment. Thus, understanding the effect of radiation on transport within the lesion and surrounding interstitium will …
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Examining location-specific invasive patterns: linking interstitial fluid and vasculature in glioblastoma
… therapies. Thus, tumor recurrence is inevitable. Interstitial fluid surrounds all of the cells in the body and has been linked to elevated invasion in glioma, which highlights the importance of this understudied fluid compartment in the brain. The primary objective of this dissertation was to …
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Proteomic analysis of interstitial fluid for novel markers of the cutaneous response to injury
… to characterise of the protein content of the fluid obtained using microdialysis, dialysate. The phosphorylation status of proteins was also characterised following the implementation and optimisation of a recently reported method that uses dendrimer conjugation chemistry to capture …
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The Role of Interstitial Fluid Flow in the Progression of Glioblastoma and Alzheimer's Disease
… conditions are characterized by a disruption in interstitial fluid flow (IFF) and an increase in neuroinflammation. Throughout the following dissertation, we examined the role of IFF in AD and GBM progression using a three-sided approach (in vivo, in vitro, and in silico). Increased IFF underlies …
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Effects of Combined Bevacizumab and Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model
… of Combined Bevacizumab and Paclitaxel on Tumor Interstitial Fluid Pressure in a Preclinical Breast Cancer Model by Ricardo H. Alvarez Several mechanisms of cell resistance are often accountable for unsuccessful chemotherapy against cancer. Another reason, which has received increased attention, …
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A Quantitative Analysis of Interstitial Fluid-Chemistry and Limestone Dissolution Rates Within the Clastic Sediment of a Karst Aquifer Conduit, Mammoth Cave, Kentucky
… and ceiling are in contact with the dissolving fluids. An approach using limestone tablet weight loss experiments, along with water sampling and geochemical modeling, has been undertaken to understand the nature of fluid movement and chemistry with the sediment beneath an active flowing cave …
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A pharmacodynamic model of the response of Staphylococcus aureus in an in vitro system simulating the pharmacokinetics of penicillin G in the interstitial fluid of sheep
… on the pharmacokinetics of penicillin G in the interstitial fluid (ISF) dialysate in sheep.
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… activation in breast cancer cells in response to interstitial fluid flow. Additionally, we explored the involvement of AMPK in breast cancer cell migration. An in-vitro three-dimensional (3D) cell culture model utilizing collagen-Matrigel matrices was used. Interstitial fluid flow was applied to …
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A three constituent mixture theory model of cutaneous and subcutaneous tissue in the context of neonatal pressure ulcer etiology and prevention
<p>Localized ischemia, impaired interstitial fluid flow, and sustained mechanical loading of cells have all been hypothesized as mechanisms of pressure ulcer (PrU) etiology. Time-varying loading has experimentally been shown to increase fluid flow in human skin <em>in vivo.</em> Towards the design …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… progression and how stromal elements impact interstitial fluid dynamics. This dissertation examines dual aspects of this complexity: first, by elucidating the specific contributions of Fusobacterium nucleatum (F. nucleatum) to pancreatic cancer pathogenesis and developing a novel therapeutic …
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Investigating the angle or response and maximum stability of a cohesive granular pile
… of a granular heap made cohesive by an interstitial fluid. I present the results of experimental work measuring the maximum angle of stability and the angle of repose of such a pile in a rotating drum geometry. I discuss existing models for the stability of a cohesive granular pile and …
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The effect of the interstitial flow on the directional cell migration and sprouting of capillaries
… project focuses specifically on the effect of interstitial fluid flow on the capillary morphogenesis process. Interstitial fluid flow is defined as flow perpendicular to the endothelial monolayer, as opposed to shear flow which is parallel. Interstitial flow is an essential process in vivo both …
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Clinical feasibility of Raman spectroscopy for quantitative blood glucose measurement
… withdrawal or through invasive access to the interstitial fluid. While Raman spectroscopy has been studied as a possible non-invasive optical technique for measuring blood glucose, it still faces several practical difficulties. These include tissue turbidity and autofluorescence, the lag …
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Dynamics of vascular normalization during anti-angiogenic therapy : implications for combination therapy
… the vascular permeability to macromolecules and interstitial fluid pressure are reduced. By lowering interstitial fluid pressure while maintaining microvascular pressure, DC101 induces a hydrostatic pressure gradient across the vascular wall, which leads to enhanced penetration of macromolecules …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… such as lymph nodes (LNs), which drain excess interstitial fluid and eventually return it to the blood circulatory system via the thoracic duct and subclavian veins. It plays a key role in interstitial fluid homeostasis, adaptive immune response, biomolecular uptake (dietary lipid, albumin, …
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Multimaterial, multifunctional fiber-based designs for integration into minimally invasive and wearable, translatable medical devices
… testing of such devices. A minimally invasive interstitial fluid glucose biosensor as well as a wearable sweat sensing glucose biosensor are presented. Moreover, a conductive fiber design is evaluated for pH sensing and integrative capabilities. Additional work and future areas of interest are …
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