Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"interstitial flow"”.
-
Effects of interstitial flow on tumor cell migration
Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells. However, due to limitations in …
-
Stimulation of angiogenesis through collagen gel by applying shear stress and interstitial flow
… of this mechanical stimulus, a parallel plate flow chamber was designed and tested to elicit a constant laminar flow onto a monolayer of endothelial cells. The goal of this research was to develop a more physiologically similar in vitro system to study the effects of shear stress on endothelial …
-
Microfluidic Dual-Gel Cell Culture Model For Studying Cell Migration Under Controlled Interstitial Flow
<p>Abstract</p> <p>Interstitial flow, the slow flux of fluid occurring in the interstitial space of the extracellular matrix (ECM), affects the migration of many cell types through individual and synergistic contributions of several biophysical and biochemical phenomena. Notably, interstitial flow …
-
The effect of the interstitial flow on the directional cell migration and sprouting of capillaries
… project focuses specifically on the effect of interstitial fluid flow on the capillary morphogenesis process. Interstitial fluid flow is defined as flow perpendicular to the endothelial monolayer, as opposed to shear flow which is parallel. Interstitial flow is an essential process in vivo both …
-
Developing a 3D in vitro Model by Microfluidics
… and cell injection as well as controlling the interstitial flow through a syringe pump. To demonstrate the effectiveness of our model, we further examine the migration of the MDA-MB-231 breast cancer cells in the porous <em>in vitro </em>model in the presence of a concentration gradient of …
-
Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… of mechanical stimuli, more specifically interstitial flow, on the formation of lymphatic sprouts to which we observe a dependency on the synergistic stimulus from the presence of pro-angiogenic factors while inducing interstitial flow. In summary, these results elucidate the physiological …
-
Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
… unknown. In addition to macrophages, elevated interstitial flow (the flow of tissue fluid) within the tumor tissue has been shown to influence cancer cell and fibroblast migration. Nevertheless, the effects of this tumor-associated biophysical force on macrophages are still unknown. In this …
-
The Development of a Printable Device with Gravity-Driven Flow for Live Imaging Glioma Stem Cell Motility
… responses with and without the presence of interstitial flow. Interestingly, GSCs from a single patient are heterogeneous, displaying differences among sub-colonies derived from the same parental line. To study the motility of cells under flow, PDMS microfluidics are commonly used. …
-
Mechanotransduction of interstitial fluid stresses and effects on tumor cell migration
… within the extracellular matrix (ECM) drive flow of interstitial fluid through the ECM. Elevated osmotic pressure, lymphatic collapse, solid stress, and increased microvascular permeability contribute to elevated interstitial fluid pressure (IFP) during carcinoma progression, and high …
-
Enhancement of fine particle deposition to permeable sediments
… using treatments that covered a wide range of flow, particle, and bed conditions. Specific treatments demonstrated large enhancements (up to eight times settling). Delivery of particles to the interface is important, but models based on delivery alone failed to predict the observed enhancement. …
-
Design of a microreactor for studying the effect of shear stress on angiogenesis in self-assembling peptide matrix
… formation and elongation in the direction of interstitial flow in response to physiological levels of shear stress [approximately] 10 dynes/cm², as well as increased cell viability; negligible shear control samples demonstrate no lumen formations and lower cell density. In order to gain more …
-
3D modelling by computational fluid dynamics of local interactions of momentum, mass and heat transfers with catalyst deactivation in gas-solid catalytic reactors of low aspect ratios
… a detailed knowledge of local dynamics of flow, composition and temperature. Unfortunately, investigations for the development of 3D modelling codes by computational fluid dynamics are still not sufficiently mature compared with those relying on 2D modelling or simplified pseudo-homogenous …
-
Enhancement of fine particle deposition to permeable sediments
… using treatments that covered a wide range of flow, particle, and bed conditions. Specific treatments demonstrated large enhancements (up to eight times settling). Delivery of particles to the interface is important, but models based on delivery alone failed to predict the observed enhancement. …
-
Examining location-specific invasive patterns: linking interstitial fluid and vasculature in glioblastoma
… therapies. Thus, tumor recurrence is inevitable. Interstitial fluid surrounds all of the cells in the body and has been linked to elevated invasion in glioma, which highlights the importance of this understudied fluid compartment in the brain. The primary objective of this dissertation was to …
-
Development of a methodology for applying shear stress to suspended mammalian cells
… fluids transmission paths, including the tissue interstitial flow, the bone marrow, and the alveolar-capillary barrier. Such shear stress constitutes an important part of the growth environment of cells in vivo. When it comes to the in-vitro situation, cells are either deprived of such mechanical …
-
Hydrodynamics and sedimentary structures of antidunes in gravel and sand mixtures
… associated with bedforms in unidirectional flow. Based on this understanding, three suites of experiments were designed and conducted to elucidate turbulent flow structure within the standing waves above antidunes and to record the sedimentary response of a loose mobile bed that constituted …
-
Investigation of Momentum and Heat Transfer in Flow Past Suspensions of Non-Spherical Particles
… (IBM). The method enables the calculation of the interstitial flow and pressure field surrounding each particle in suspension leading to the direct integration of fluid forces acting on each particle in the suspension. A substantial outcome of the research is the development of a new drag force …