Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"interstitial fibrosis"”.
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Zur Rolle von C5 und [alpha]5[beta]1-Integrin für die Entstehung von renaler Fibrose und mögliche therapeutische Konsequenzen
Tubulointerstitial fibrosis is the final stage of many progressive renal diseases. The aim of this study was to test new strategies of treatment in a mouse model which could be applied to clinical practise in future. We used C5-deficient-mice as well as specific C5aR-and alpha5beta1-Integrin …
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Cardiac magnetic resonance imaging for non-invasive detection of myocardial fibrosis
… population. This research focuses on myocardial fibrosis, a precursor of cardiovascular diseases. At least initially, myocardial fibrosis is a healing response when the human heart is injured or inflamed. An increase in the deposition of collagen I and collagen III occur in the heart during this …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… media to lumen ratio (M/L) by 50%, perivascular fibrosis by 24% and interstitial fibrosis by 46%. These structural reductions were associated with a 32.8% decrease in connective tissue growth factor (CTGF), a 43.1% inhibition in phosphorylated Smad 2 and a 66.2% reduction in phosphorylated ERK1/2 …
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Benzo[a]pyrene effects on Fundulus heteroclitus reproductive endpoints
… 10 μg/L BaP. An increase in empty follicles and interstitial fibrosis was observed by histopathological examination of testes. Other biomarkers including male liver somatic index (LSI), liver vitellogenin (vtg) mRNA expression and sperm concentrations were not significantly affected. In females, …
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Cardiovascular consequences of anabolic steroid use
… determine the presence of perfusion defects and interstitial fibrosis. We observed that AS users had a hypertrophy of both the left and right ventricles that was concomitant with diastolic dysfunction in the left ventricle and a reduction in right ventricular contractility. Despite these findings …
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Protective Effects of Yuzu and Its Component against Cardiovascular Disease
… includes ventricular dilatation and increased interstitial fibrosis after myocardial infarction (MI), is the critical process underlying the progression to heart failure (HF). Therefore, a novel approach for preventing LV remodeling after MI is highly desirable. Yuzu is a citrus plant …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… due to renal ischemia. Microscopically, marked interstitial fibrosis with focal necrosis and diffuse perivascular fibrosis in the myocardium were observed. Myocardial fibrosis appears before myocyte necrosis and its severity is proportional to the duration of established hypertension and the …
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Correlation of urinary mcp-1 and tweak with renal histology and early response to therapy in newly biopsied patients with lupus nephritis in cape town, South Africa
… (LN class, activity index, chronicity index and interstitial fibrosis). At 6 months, 6 patients were lost to follow-up and of the remaining 14, 12 (85%) attained remission (partial remission (n = 7) or complete remission (n = 5)). Both biomarkers were elevated in patients with active disease and …
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FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… inflammation, progressive perivascular and interstitial fibrosis. SSc pathogenesis is largely unknown, however strong evidences suggest that genetic predisposition may contribute to SSc development. Dysregulation of co-stimulatory and/or co-inhibitory signals, including ICOS signalling, can …
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The effects of magnesium administration on cardiac ventricular function, heart rate variability, and myocardial morphological changes in a chronic diabetes disease model in rats
… cardiomyocyte width or in the extent of interstitial fibrosis in all groups. Western blot analysis qualitatively showed a decrease in the expression of synaptophysin in DM that was prevented by Mg2+ treatment. Neither DM nor Mg2+ treatment altered ATP5A expression. The plasma Mg2+ …
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Elucidating the role of LARP6 in cardiovascular remodeling
… prevented by the 5'SL mutation. Interestingly, fibrosis was not induced by the diet, therefore the protective effect of the 5'SL mutation was mediated through collagen independent effects. To increase focus on the role of LARP6 in cardiac fibrosis, we used a model of Ang II infusion (1000 …
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The Impact of Ventricular Assist Device Prior to Transplantation on Morphological Parameters in Cardiac Allografts /// Въздействие на вентрикуларните помощни устройства преди трансплантация върху морфологичните параметри при сърдечните алографи
… cellular rejection (ACR) and an increase of interstitial fibrosis (IF) often correlate with impaired ventricular function. The innate immune system, in particular macrophages, plays an important role in the resorptive process of ACR and is, on the other hand, known to promote IF. In this …
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Studies of immunoglobulin receptors and human proximal tubular cells
… and progressive glomerular and tubulointerstitial fibrosis, reduction in glomerular filtration rate (GFR), and retention of uremic toxins. The rate of progression of GN is increased by various clinical factors including hypertension, and the quantity and specificity of proteinuria. …
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Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment
… was associated with a significant decrease in interstitial fibrosis, from 4.9 ± 1.0%/field to 1.2 ± 0.2%/field in BT474 tumors and from 23.3 ± 2.4%/field to 8.3 ± 0.8%/field in ZR-75-1 tumors, and a 66% reduction in collagen I deposition. Treatment with Ang-(1-7) also decreased perivascular …
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Die Wnt-Signalkette in der Pathophysiologie der kongenitalen obstruktiven Uropathie der Ratte
Ziel: Um die Rolle der Wnt-Signalkette in Hinblick auf die Pathophysiologie der kongenitalen obstruktiven Uropathie der Ratte zu ergründen, wurden in der vorliegenden Arbeit die Expressionsmuster ausgewählter Gene untersucht. Methoden: Es wurde die totale zelluläre mRNA aus Nieren von Ratten …