Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"intermediate filament proteins"”.
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Novel Intermediate Filaments in the Nuclear Envelope: Molecular Cloning and Analysis of Lamins A and C
… major polypeptides of the nuclear lamina, the filamentous meshwork intercalated between chromatin and the inner nuclear membrane. Amino acid sequences have been deduced from cDNA clones of human lamins A and C which show identity with the exception of an additional 98 amino acid residue …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… with an increased concentration in heat shock proteins. While the severely affected cardiac muscle exhibited drastic decreases in the expression levels of many proteins involved in energy metabolism including adenylate kinase and many ATP synthase isoforms. Reduced concentrations were also …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
<p>The A-type lamins are intermediate filament proteins that constitute a major part of the eukaryotic nuclear lamina—a tough, polymerized, mesh lining of the inner nuclear membrane, providing shape and structural integrity to the nucleus. Lamin A (LA) filaments also permeate the nucleoplasm, …
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Structural and mechanical properties of intermediate filaments under extreme conditions and disease
Intermediate filaments are one of the three major components of the cytoskeleton in eukaryotic cells. It was discovered during the recent decades that intermediate filament proteins play key roles to reinforce cells subjected to large-deformation as well as participate in signal transduction. …
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GFP- coated microparticles to quantify and compare wild- type desmin with known desmin mutations in human heart disease via quantitative live-cell fluorescence Imaging
… (p.D312A), desmin is an essential protein of the intermediate filaments in myocytes, and its mutations are associated with many cardiac and skeletal muscle disorders. C2C12 myoblast cells were transiently transfected with tagged desmin constructs carrying enhanced green fluorescent protein (EGFP) …
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Lamin A and lamin C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy
… gene which gives rise to lamin A and lamin C proteins by alternative splicing. These A-type lamins, together with B-type lamins, form the nuclear lamina, a network of intermediate filament proteins underlining the nuclear envelope. In order to ascertain the role lamin A and C separately …
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Identification of genetic variation in the Keratin-associated protein and KRT33A genes of the Swakara sheep of Namibia
Keratins are structural intermediate filamentous proteins that constitute about 90% of the total wool fiber in sheep. The protein gene family is divided into two groups which are the Keratin Intermediate-Filament proteins (KRTs) and the Keratin-Associated proteins (KAPs). The KRTs form the skeletal …