Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"intermediate filament"”.
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Assembly and localization of the intermediate filament protein, nestin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Identification of altered Ras signaling and intermediate filament hyperphosphorylation in giant axonal neuropathy
… organization of cytoskeletal proteins called intermediate filaments (IFs), which normally provide strength and support for the overall cell structure. The irregular IF structure in GAN patient neurons leads to a progressive loss of motor skills in children and subsequent death in adolescence. …
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Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… <p>staining patterns of vimentin filaments increased in number and complexity in</p> <p>U18666A-treated normal human fibroblasts similar to NPC fibroblasts. Inhibition of PKC by bisindolylmaleimide 1 (Bis-1) treatment of 1c1c7 cultures favored the formation of filamentous vimentin, …
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Novel Intermediate Filaments in the Nuclear Envelope: Molecular Cloning and Analysis of Lamins A and C
… major polypeptides of the nuclear lamina, the filamentous meshwork intercalated between chromatin and the inner nuclear membrane. Amino acid sequences have been deduced from cDNA clones of human lamins A and C which show identity with the exception of an additional 98 amino acid residue …
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Structural and mechanical properties of intermediate filaments under extreme conditions and disease
Intermediate filaments are one of the three major components of the cytoskeleton in eukaryotic cells. It was discovered during the recent decades that intermediate filament proteins play key roles to reinforce cells subjected to large-deformation as well as participate in signal transduction. …
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Impact of Vimentin Intermediate Filaments on 3D Multicellular Collective Behavior
Vimentin, a type III intermediate filament, is an understudied component of the cytoskeletal system. However, in recent studies we can see its structural and mechanical properties aid in a cell's survival and migration. It forms a hyperelastic network and works synergistically with actin and …
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Cyclic AMP and the Induction of Reactive Astrogliosis
… recognize a phosphoepitope found on the nuclear intermediate filament, lamin, as well as the cytoplasmic intermediate filament characteristic to mammalian astrocytes, glial fibrillary acidic protein (GF AP), suggesting that mAB Jl-31 is an appropriate marker for astrocytes entering the reactive …
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First evidence of skelemin, a myosin-associated protein, in smooth muscle and its involvement in cell adhesion, and, The role of the cell cycle in cell type choice during mammalian development
… antibodies colocalized with the myosin-II filaments as well as the desmin intermediate filament cytoskeleton. This is the first evidence of a myosin-associated protein within smooth muscle, and it raises the possibility that smooth muscle myosin may be more organized than has been assumed. …
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Mechanisms of microcystin-LR toxicity
… in vivo and in vitro, and disrupts actin microfilament (MF), microtubule (MT) and intermediate filament (IF) networks. The sequential ultrastructural and biochemical changes induced by MCLR were studied in the isolated perfused rat liver model. Livers were perfused with doses ranging from 0.1 …
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Fiber Type-specific Desmin Content in Human Single Muscle Fibers
… of this study was to compare the content of the intermediate filament protein, desmin, between type I and type IIa single muscle fibers from a mixed muscle in human subjects. Biopsies were taken from the vastus lateralis of six recreationally active males. Approximately 150 single muscle fibers …
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Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells
… expressing mesenchymal markers. Of these, the intermediate filament protein vimentin is frequently upregulated in metastatic carcinomas. Previously, microarray studies showed that the gene encoding vimentin is highly upregulated in metastatic HN12 cells compared to a related primary tumor cell …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… observed in numerous contractile proteins and intermediate filament proteins. With the loss of these structural elements, a drastic increase in stress proteins was observed within dystrophic myofibrils compared to normal fibres. This thesis has successfully identified novel biomarkers that may …
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Developmental Appearance of Phosphorylated Intermediate Filaments in Nuclei of Glioma and Neuroblastoma Cells
… vaguely known. Investigations into the role of intermediate filaments (IF) in the nucleus have primarily focused upon lamins, however some studies have suggested that there may be a role for non-lamin intermediate filaments in the nucleoskeleton. Recent studies of glioma and neuroblastoma cell …
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hepatocyte growth factor inhibits glial scar formation and
… was associated with dramatic upregulation of intermediate filament, GFAP (glial fibrillary acidic protein), which was evidently suppressed by HGF cotreatment in a dose-dependent manner. HGF also inhibited TGFβ1-induced upregulation of neurocan, one of CSPG species. To explore whether glial …
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Effect of cellular factors on the generation of beta-amyloid.
… their formation nor are they contained by the intermediate filament vimentin, indicating that they are neither aggresomes nor inclusion bodies. Moderate to high levels of the fusion protein disrupt the endoplasmic reticulum and Golgi compartments, suggesting that the normal trafficking of …
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Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells
… pool of sPLA2 is the rod domain of vimentin, an intermediate filament protein that is exposed by caspase activity when cells undergo apoptosis. Based on these observations, we hypothesize that the exposure of vimentin on apoptotic cells traps a pool of catalytically active sPLA2 that then …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
… novel PKCε-interacting proteins, including the intermediate filament peripherin and several mRNA-binding proteins. Peripherin and three RNA-binding proteins G3BP2, PABPC1, and IGF2BP3 were further investigated regarding their putative function in PKCε-mediated neurite outgrowth. However, no …
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Astrocyte: Neuron Interactions in the Juvenile Form of Batten Disease
… Cln3-l- astrocytes have a disrupted actin and intermediate filament cytoskeleton. Possibly due to these defects, Cln3-l- astrocytes have an attenuated ability to response to an activation stimulus, just as observed in vivo, and to<br/>divide and migrate. They also display pronounced defects in …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
<p>The A-type lamins are intermediate filament proteins that constitute a major part of the eukaryotic nuclear lamina—a tough, polymerized, mesh lining of the inner nuclear membrane, providing shape and structural integrity to the nucleus. Lamin A (LA) filaments also permeate the nucleoplasm, …
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