Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"interleukin-7"”.
-
Investigation of the role of antagonism of the Interleukin-7 Receptor in the treatment of Multiple Sclerosis in Humans and In Vitro differences between genetically stratified subjects based on Interleukin-7 Receptor Genotype
Multiple Sclerosis is an autoimmune disease mediated by activated lymphocytes entering the central nervous system. Treatments with the greatest efficacy either prevent the entry of activated lymphocytes, or deplete the lymphocyte population, before allowing lymphocyte reconstitution. IL-7Rα was …
-
Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
Human Immunodeficiency Virus (HIV) infection is known for depleting ‘helper’ CD4+ T cells. Highly active antiretroviral therapy (HAART) reduces viremia and increases CD4+ levels, however, 5-20% of patients fail to reconstitute CD4+ T cell levels despite viral suppression. Interluekin-7 (IL-7), a …
-
A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
… recently shown to regulate the expression of the interleukin-7 receptor alpha chain (IL-7R[alpha][alpha]) via the Foxol transcription factor.
-
Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… cytokines such as interferon-gamma (IFNγ), interleukin-7 (IL-7) and granulocyte macrophage-colony stimulating factor (GM-CSF). In the N32 rat glioma model there is a synergistic therapeutic effect when combining immunization with IFNγ- and- IL7-producing tumor cells and this coincides with …
-
Characterization of human foreskin Langerhans cells
… an over-abundance of proteins involved in the interleukin 7 response and mRNA catabolic processes, while the outer FS had more spindle zones and cornified envelope proteins that were over-abundant when comparing inner and outer FS from 5 participants. Discussion and Conclusion: The study …
-
Mutational Analysis of CD127 and Its Role in Immunological Diseases
Interleukin (IL) -7 is an essential non-redundant cytokine that influences T-cell differentiation, proliferation, homeostasis and T-cell functions. In T-cells, IL-7 signals are transduced via IL-7's heterodimeric receptor composed of a common, γ chain (CD132) and an IL-7 specific, α chain (CD127). …
-
Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… an immunoglobulin BCR (IgM). Signalling via the interleukin-7 receptor (IL7R) and the preBCR are required for successful progenitor B cell development in mice. There has also been mounting evidence implicating insulin-like growth factor 1 receptor (IGF1R) signalling to progenitor B cell …
-
Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… a robust adaptive immune response. The roles of interleukin-7 receptor, pre-BCR and chemokine receptor type 4 signalling are well established in this process. There is now growing evidence supporting a role for Insulin-like Growth Factor 1 Receptor (IGF1R) signalling in progenitor B cell …
-
Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
During the course of an immune response, CD4+ T helper cells differentiate into a number of subsets including: T helper 1 (TH1), TH2, TH17, and T follicular helper (TFH) populations. The functional diversity of CD4+ T effector cells results in a coordinated, pathogen-specific immune response. For …