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Showing 1 to 20 of 247 for “"interleukin-6"”.
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Detection of glial interleukin-6 release: Development of a novel interleukin-6 Elisa
The development of an interleukin-6 (IL-6) enzyme-linked immunosorbent (ELISA) assay resulted in a detection range of 1 ng/m1 to 10 ng/mL IL-6. The limit of detection (LOD) for IL-6 was 0.25 ng/mL. Troubleshooting techniques were attempted including matrix effects, non-specific binding, and coating …
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Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem : lokale Applikation d. Designerzytokins Hyper-Interleukin-6 im adulten Organismus d. Ratte u. Auswirkungen v. exzitatorischen Neurotoxinen im Interleukin-6 transgenen Mausmodell
… Expression des Designerzytokins Hyper-Interleukin-6 (H-IL-6) im <br>Zentralnervensystem (ZNS) entwickelt. H-IL-6 besteht aus humanem Interleukin-6 (IL-6) verbunden mit löslichem IL-6 Rezeptor (sIL-6R). Erstmalig wurden hierfür makroverkapselte, H-IL-6 exprimierende Maus-Melanomzellen …
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Tissue specific genetic regulation of Interleukin 6
Interleukin 6 (IL6) is associated with arterial disease development, progression and surgical outcome. Raised levels of IL6 may play a causal role in disease development or may be the effect of pathology. An IL6 single nucleotide polymorphism (SNP) G- 174C has been identified and reported to …
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Regulation of Adrenal Steroidogenesis by Interleukin-6
Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of …
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
… no effective treatments available. Inhibition of interleukin 6 (IL-6) results in the attenuation of pulmonary fibrosis in mice. It is unclear whether this is due to blockade of classical<em> </em>signaling, mediated by membrane-bound IL-6 receptor alpha (mIL-6Rα), or trans signaling, mediated by …
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Methamphetamine, interleukin-6 and perineuronal nets in synaptic plasticity
… stress and lipid peroxidation mechanisms. Interleukin-6 (IL6) is a pleiotropic cytokine that is a mediator of immune and inflammatory processes. IL6 is known to mediate METH-induced neurotoxicity. We used mice models to test a combination of a clinical dose of METH and IL6 deficiency on …
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Die Rolle von Interleukin-6 beim Myelinabbau durch Makrophagen
In den letzten Jahren sind die Einflüsse von Zytokinen auf die Myelinbeseitigung immer mehr in den Focus wissenschaftlichen Interesses gerückt. Ziel der vorliegenden Arbeit ist die Klärung der Rolle des IL-6 beim Myelinabbau im peripheren Nerv. Die vorliegende Arbeit bietet Anhalt dafür, dass das …
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Die Rolle des Interleukin-6 bei der Wallerschen Degeneration
Die Rolle des Interleukin-6 bei der Wallerschen Degeneration. Untersucht wurde mit Hilfe von Interleukin-6 Knockout Mäusen die Rolle des Interleukin-6. Am Modell der Axotomie 4- und 6-Tage nach Axotomie des N. ischiadicus im Vergleich zu Wildtyp-Mäusen. Untersucht wurden immunhistochemisch die …
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Genetic Polymorphisms of Interleukin-6 in Systemic Lupus Erythematosus
… production of pathogenic autoantibodies. Interleukin-6 (IL-6) is a multifunctional cytokine that mediates inflammatory and immune responses, and IL-6 gene polymorphisms are known to play a part in chronic inflammatory and autoimmune disorders. We have identified single nucleotide …
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Interleukin-6 and its Contribution to Embryogenesis in Cattle
… investigated this by supplementing a cytokine, interleukin-6 (IL6), during in vitro embryo culture. My dissertation work expands upon those initial efforts by answering more detailed questions related to the biological role of IL6 during cattle embryogenesis. In the work presented herein, IL6 …
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Interleukin-6 Levels in Generalized and Localized Aggressive Periodontitis Patients
AbstractINTERLEUKIN-6 LEVELS IN GENERALIZED AND LOCALIZED AGGRESSIVE PERIODONTITIS PATIENTSBy Bindu Reddy, D.D.S.A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at the Virginia Commonwealth UniversityVirginia Commonwealth University, 2004Major …
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Interleukin-6, Depression, and Religious Coping in Older Seventh-day Adventists
… depressive symptoms and the inflammatory marker, interleukin-6 (IL-6), interact over time in 287 older adults (54% female, 63% White, Mage = 66, SDage = 10.9) from the Biopsychosocial Religion and Health Study and whether religious coping moderated this relationship. Depressive symptoms and IL-6 …
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Autocrine Effects of Catecholamines on Macrophage Release of Interleukin-6 (IL-6)
… have both stimulatory and inhibitory effects on interleukin-6 (IL-6). This study was designed to clarify the autocrine role of macrophage-derived NE on IL-6 production in activated peritoneal macrophages. Effects of NE on IL-6 production in the RAW264.7 macrophage cell-line also were …
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Rolle der Src-Kinasen in den Signaltransduktionswegen von Interleukin-6 und Erythropoetin
Wir zeigten in dieser Arbeit, dass Mitglieder der Src-Kinasen Familie durch IL-6 und Epo aktiviert werden und mit deren Rezeptoren, vor allem dem EpoR, assoziieren. Darüber hinaus scheint die Src-Kinase Lyn eine Rolle in der erythrozytären Differenzierung zu spielen.
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Regulation of Interleukin -6 Gene Expression in the Brain of Aged Mice
… on the expression of inflammatory cytokine, interleukin-6 (IL-6), was determined. Competitive RT-PCR and ELISA assay showed that IL-6 mRNA and protein concentration were higher in aged brain compared to adult and neonate brain. To begin identifying the cell type responsible for increased IL-6 …
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Dietary Magnesium, C-Reactive Protein and Interleukin-6: The Strong Heart Family Study
… inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)) among American Indians (AIs). Methods: This cross-sectional study included AI participants (n=1,924) from the Strong Heart Family Study. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block …
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Interleukin-6 trans-signaling: implications for neuroinflammation and cognitive deficits in the aged
… amounts of pro-inflammatory cytokines, such as interleukin (IL)-6. The over production of IL-6 during aging is correlated with acute behavioral deficits in response to a peripheral infection or chronic behavioral deficits in the development of neurodegenerative diseases, such as Alzheimer’s and …
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