Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"interleukin-1beta"”.
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Klonierung und Charakterisierung des Interleukin-1beta-Systems im Gehirn von Callithrix jacchus
Als neues Tiermodell zur Untersuchung des Interleukin-1b-Systems im Gehirn wurde die Gattung der nichtmenschlichen Primaten Callithrix jacchus ausgewählt.In der vorliegenden Arbeit wurde zunächst erstmals der Einfluß der künstlichen Stressung mittels Lipopolysaccharid (LPS) und deren Auswirkung auf …
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Estrogen Regulation of Proteinase Inhibitor 9 Gene Expression and Interleukin-1beta Production
The ability of several estrogens and antiestrogens to activate PI-9 gene expression was assessed by transient transfection. Of interest, the mixed agonist/antagonist tamoxifen (OHT) was an agonist on the transiently transfected reporter gene but behaved as an antagonist on the cellular gene. To …
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Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells.
… metabolism post myocardial infarction (MI). Interleukin-1β (IL-1β), a proinflammatory cytokine increased in the heart post-MI, is considered essential for angiogenesis in tumor growth and metastasis, arthritis, endometriosis, and wound healing. Matrix metalloproteinases (MMPs) are implicated …
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Modulation der Expression von Integrin-Beta4, Interleukin-1Beta und HMGA in humanen kolorektalen Karzinomzellen durch Butyrat
… der Proteine Integrin-ß4 (Zelladhäsionsfaktor), Interleukin-1ß (Entzündungsfaktor) und HMGA (Transkriptionsfaktor) ab 48 Stunden Inkubationszeit mit 2mmol/l Butyrat in der gut-differenzierten HT-29-, der entdifferenzierten SW-480-Kolonadenokarzinomzelllinie sowie deren Metastasenzelllinie SW-620 …
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Extracullular Atp Regulates Il-1beta Release From Microglial Cells Via Purinergic Receptor After In Vitro Trauma
… cytokines. Current literature suggests that interleukin-1Beta is an important cytokine mediator, which is dramatically increased after brain injury. Previous studies indicate that ATP is released by traumatically injured astrocytes and serves as a cell-to-cell mediator through purinergic …
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Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
Precursor interleukin-1beta (IL-1beta) is cleaved by interleukin-1beta converting enzyme (ICE) to generate the biologically active form of IL-1beta. Interleukin-1beta synthesized in the brain is thought to be involved in the induction of sickness behavior by lipopolysaccharide (LPS). In the first …
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Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen
… Lithium, Lamotrigin und Valproat auf die Interleukin-1beta induzierte Cyclooxygenase-2-Synthese in humanen SK-N-SH Neuroblastomzellen mittels Western Blot und Enzymimmunoassay untersucht werden. <br>VPA erwies sich als potenter Hemmer der Interleukin-1beta induzierten COX-2-Synthese. Unter …
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Detection of glial interleukin-6 release: Development of a novel interleukin-6 Elisa
The development of an interleukin-6 (IL-6) enzyme-linked immunosorbent (ELISA) assay resulted in a detection range of 1 ng/m1 to 10 ng/mL IL-6. The limit of detection (LOD) for IL-6 was 0.25 ng/mL. Troubleshooting techniques were attempted including matrix effects, non-specific binding, and coating …
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The role of VIP family members in diabetic retinopathy
… cytokines and vasoactive peptides, such as interleukin-1beta and vascular endothelial growth factor (VEGF). To date, intravitreal injection of agents directed against VEGF represents the elective DR therapy. However, they counteract efficaciently ocular neovascularization only in 50% of …
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… immune-mediated pancreatic beta-cell death. IL-1beta (interleukin 1beta), a proinflammatory cytokine, induces ER (endoplasmic reticulum) stress and activates proapoptotic networks in beta cells, such as NF-kappaB (nuclear factor-kappaB) and JNK (c-Jun N-terminal kinase) signaling pathways. The …
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Inulin Supplementation to Support Periodontal Health
… and post ST. Salivary markers of inflammation (interleukin-1beta, interleukin-6, c-reactive protein and matrix metalloproteinase-8), periodontal-associated pathogens (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia and Aggregatibacter actinomycetemcomitans), body mass index …
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Comparing live to recorded music and stories using multiple psychoneuroendocrine and psychological measures
… cortisol, alpha-amylase, immunoglobulin-A, interleukin- 1beta, and pH levels were measured. Saliva samples from 50 university students and 23 palliative care and surgical patients were compared before and after each participant listened to a live (ML), audiovisual (MAV) or audio recorded …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
… non-MS individuals. Pro-inflammatory cytokines (interleukin-1beta , tumour necrosis factor and interferon-gamma) increased the expression of both CCL2 and CXCL10 by astrocytes at the mRNA and protein level, as determined by real time PCR and enzyme linked immunosorbent assays (ELISA), …
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The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… of proinflammatory cytokines such as interleukin 1beta (IL-1beta) and proteases including matrix metalloproteinases (MMPs). Cannabinoids have been shown to reduce joint damage in animal models of arthritis and have also been shown to prevent IL-1 induced matrix breakdown of collagens …
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Mechanisms of Cytokine-Induced IGF -I Insensitivity in Cancer Cells
… tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), inhibit IGF-I-promoted DNA synthesis in human MCF-7 breast adenocarcinoma cells, T-47D breast ductal carcinoma cells, murine FDCP progenitor myeloid cells and human promyeloid HL-60 cells. Flow …
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Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes
… predominantly driven by elevated levels of interleukin-1beta (IL-1b), in addition to tumour necrosis factor-alpha (TNF-a). Endotoxins such as lipopolysaccharide (LPS), or Nitric Oxide donors such as S-nitroso-Nacetylpenicillamine (SNAP) has also been reported to play a role in the …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… expression of leukaemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNFalpha) in the human endometrium of normal fertile women throughout the menstrual cycle. The results showed that staining …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… cues however, I found that signaling through interleukin (IL)-1 receptor family is required for effector cytokine production by memory CD4 T cells. Mechanistically, IL-1R signaling provides post-transcriptional stability to T cell cytokine transcripts thereby enabling productive secretion of …