Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"interleukin-1B"”.
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Investigation of Interleukin 1B synthesis and secretion by dendritic cells: Interplay between toll-like receptor and FCG receptor
Interleukin-1I? (IL-1I?) is a prototypic multifunctional cytokine. It not only mediates inflammatory response in innate immunity, but also modulates antigen-specific immunity. Dendritic cells (DCs) are central regulator of immune activation and tolerance. However, the regulation of IL-1I? …
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Klonierung und Charakterisierung des Interleukin-1beta-Systems im Gehirn von Callithrix jacchus
Als neues Tiermodell zur Untersuchung des Interleukin-1b-Systems im Gehirn wurde die Gattung der nichtmenschlichen Primaten Callithrix jacchus ausgewählt.In der vorliegenden Arbeit wurde zunächst erstmals der Einfluß der künstlichen Stressung mittels Lipopolysaccharid (LPS) und deren Auswirkung auf …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… Mfs. Although tumor-derived factors, including interleukin-10 and transforming growth factor-b1, modulate Mf response to activation signals, paclitaxel partly reverses tumor-induced Mf-mediated suppression of T-cell reactivity through enhanced production of the immunostimulatory cytokine …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… production was up-regulated by interferon-y, interleukin-1b and ligands for Toll-like receptors 3 (TLR3) and 4 (TLR4). It was found that intracellular presence of galectin-9 in RA synovial firboblasts increased their resistance to apoptosis. Galectin-3 level are increased in teh joints of …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that activate NLRP3 inflammasome. Protein phosphatase-2A (PP2A) may be involved in regulating inflammatory pathways in macrophages. …
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Mechanisms of defective insulin secretion in type 2 diabetes
… of coexpressed genes (module), enriched for interleukin-1-related genes, was associated with T2D and reduced insulin secretion. One of the module genes that was highly overexpressed in islets from T2D patients is SFRP4, which encodes secreted frizzled-related protein 4. SFRP4 expression …
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Untersuchungen über die Interaktion von Meningokokken mit Zellen der Blut-Hirn-Schranke
… von Tumornekrosefaktor alpha (TNF-a), Interleukin-1b (IL-1b), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Monocyten-attrahierendem Protein-1 (MCP-1) und transformierendem Wachstumsfaktor beta (TGF-b) durch Gehirnendothelzellen nach Infektion mit Meningokokken analysiert. Mit ELISA und …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… a critical role in mediating pulmonary edema in interleukin-1b (IL-1b) stimulated ALI models. A transient blockade of both integrins by antibodies (Ab) or small Arg-Gly-Asp (RGD) peptide sequences may provide new causal therapies for pulmonary edema. A transcription factor, nuclear factor-kB …
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Inflammatory Mechanisms And Vulnerability For Major Depression: From Animal Models To Drug Treatment
… reduced the LPS-induced up-regulation of interleukin-1b and interleukin-6 in different brain regions as well as at peripheral level. Moreover, pre-treatment with the antidepressant was also able to interfere with mechanisms responsible for microglia activation following LPS injection and …
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Effects of endotoxin-induced inflammation on glucose metabolism and contractility of the rat heart in vivo and in vitro
… such as Tumor Necrosis Factor (TNFa) and Interleukin-1b (IL-1b). Despite the fact (i) that inflammatory cytokines are known to affect glucose metabolism in other insulin-sensitive tissues and (ii) that the utilisation of fuels by the heart is one of the determinants of its contractile …
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The study of the role of mast cells in malignant pleural effusion
… this, mast cells secreted tryptase AB1 and interleukin-1β, that, in turn, potently triggered vascular hypermeability and tumor cell nuclear factor-κΒ activation, respectively. cKIT inhibitor imatinib mesylate was effective against effusion development, indicating that mast cell-dependent …