Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"interleukin-15"”.
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Interleukin-15 and [alpha](1,3)galactosyl-expressing vaccine combination therapy for melanoma
… B16alphaGal vaccine, in the present study, IL-15-expressing vaccine cells (B16IL-15) were administered to mice in combination with the B16aGal vaccine with or without B16N/V vaccine cells (irradiated B16F0 melanoma cells). As documented in literature, IL-15 stimulates the proliferation and …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… number of patients without adequate relief. Interleukin-15 (IL-15), a cytokine pivotal in RA pathogenesis, promotes inflammatory responses and is elevated in RA patients, highlighting it as a compelling therapeutic target. This study explores the potential of IFRA3Q1, a novel peptoid …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… in ex vivo primary CD4+ T cells stimulated with Interleukin-15 (IL-15) to mimic the pathophysiological conditions of the in vivo establishment during the early phases of infection. To do that, we used the dual-reporter virus HIV-GKO, which bears two different fluorescent reporters, one under the …
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Identification of Coeliac Disease Triggering Glutenin Peptides and Their Measurement in Foods
… by an innate immune response mediated through interleukin-15.<br/>Dietary gluten comprises of two major protein fractions, gliadins and glutenins. Considerable research has been carried out on the immunostimulatory components in wheat gliadin. Glutenins, newly discovered to be toxic to coeliac …
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Financial viability and technical evaluation of dendritic cell-carrying "vaccination nodes" for immunotherapy
… potential benefit of incorporation of cytokine interleukin-15 complexed with its soluble receptor interleukin-5R[alpha], which is discussed. Economic considerations are also discussed, including topics such as intellectual property, barriers to entry, initial markets and market drivers, and …
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Signaling pathways regulating skeletal muscle metabolism and growth
… had a 3-fold increase in circulating levels of interleukin-15 (IL-15), a potent anti-obesity cytokine, potentially through epigenetic regulation of Il15 by OGT. To further investigate if there was a causal relationship between OGT ablation and the lean phenotype, we generated muscle specific OGT …
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Progesterone control of human endometrial cells
… interactions with ESCs. uNK cells replicate upon Interleukin-15 (IL-15) administration in vitro and this cytokine is expressed in the epithelial and stromal cells. The aims of this research project have been to investigate in vitro decidualisation of ESCs and regulation of IL-15 and uNK cells in …
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Anti-inflammatory Role of IL-15Rα Up-regulated by Poly I:C in Herpes Simplex Virus-induced Behcet's Disease-like Mouse Model
… vascular, and central nervous system affects. Interleukin-15 receptor alpha (IL-15Rα) forms stable complex with IL-15 on the cell surface of activated monocytes and mediates the proliferation of memory CD8+ T cells. Recent studies informed that Polyinosinic:polycytidylic acid (Poly I:C) is an …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
… is lost. Knock-out studies in mice show that interleukin 15 (IL-15) is essential for memory CD8+ T cell proliferation. Fibroblasts, macrophages, dendritic cells and epithelial cells express IL-15 and its receptor isoform [alpha] (IL-15R[alpha]). Histological studies suggest that memory CD8+ T …
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Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… to facilitate adaptation to physical exercise. Interleukin-15 (IL-15) is highly expressed in skeletal muscle and appears to influence many metabolic parameters that are defective in metabolic pathologies such as insulin resistance. For instance, IL-15 increases glucose uptake in muscle and …
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Funktionelle Charakterisierung der humanen Proteinkinase Aurora-C in Krebszellen
… wurden drei Proteine (Calpain-4, Epiplakin, Interleukin 15) identifiziert, die wie Aurora-C eine Veränderung der Zellmorphologie bewirken können. Im Rahmen dieser Arbeit wurde von den drei Proteinen allerdings nur Calpain-4 näher unter-sucht. Es konnte gezeigt werden, dass Calpain-4 in vitro …
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Elucidating The Roles of Il-15 In The Tumor Microenvironment
<p>ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT</p> <p>Rosa M. Santana Carrero, B.S.</p> <p>Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.</p> <p>Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T …
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Cytokine Gene Expressions of Peripheral Blood Mononuclear Cells in Acute Renal Allograft Rejection
… expression amounts of cytokine genes encoding Interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 10 (IL-10), interleukin 15 (IL-15), and interferon γ (INF-γ) were assessed using real time reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS IL-2, IL-4 and IL-15 mRNA …
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Role of cytokine IL-15 in the homeostasis of the intestinal epithelium and inflammatory bowel diseases
… therapeutic targets in the treatment of IBD. Interleukin 15 (IL-15) is a pro-inflammatory cytokine involved in maintenance and activation of subgroups of cytotoxic lymphocytes and macrophages in the intestinal epithelium, by acting through the 3-subunit receptor IL-15R. IL-15 receptor complex …
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… and TLR agonists enhance the expression of Interleukin (IL)-15. Additionally, inducing lymphopenia enhances anti-tumor responses in an IL-15-dependent manner. Paradoxically, despite the limited expression of IL-15 during homeostasis, the role of IL-15 during the steady state is well-known, …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
… a new recombinant myxoma virus (vMyx-IL15Rα-tdTr), which expresses an IL15Rα-IL15 fusion protein as well as tdTomato red fluorescent reporter protein, and the antitumor effect of the virus. Interleukin-15 (IL15) is an immunomodulatory cytokine with significant potential for stimulating …
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Treatment of murine tumors with recombinant Myxoma viruses
… MYXV that expresses the murine gene for interleukin 15 (IL-15) was also used, in order to determine if increased expression of IL-15 within the tumor bed could improve MYXV treatment by recruiting additional anti-tumor immune cells to the tumor. In vitro experiments evaluated MYXV …