Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"interleukin-12"”.
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Association of Interleukin-12 gene polymorphism with Hepatitis B virus persistnece and Hepatocelluar carcinoma
… of hepatocelluar carcinoma(HCC) and SNPs of interleukin(IL)-12A. METHODS: Between March 2002 and December 2004, 730 Korean patients with HBV infection and 320 healthy individuals who recovered from HBV infection were enrolled. We assessed polymorphisms and haplotype in IL-12A, and the …
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Interleukin-10 und Interleukin-12 produzierende Monozyten-Subpopulationen bei Normalpersonen und Probanden mit atopischer Diathese
… wurde die monozytäre Produktion von IL-10 und IL-12 untersucht. IL-12 ist ein proinflammatorisches Zytokin, das die zellvermittelte Abwehr aktiviert und TH1 Immunantworten induziert. IL-10 wirkt antagonistisch zu IL-12, indem es die Synthese zahlreicher Entzündungsmediatoren unterdrückt und TH2 …
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Der Einfluß zerebraler Expression von Interleukin-12 auf die neonatale Borna Disease Virus Infektion bei Mäusen
Expression von biologisch aktivem Interleukin-12 (IL-12) in Astrozyten des zentralen Nervensystems (ZNS) führt zu einer spontanen neuroimmunologischen Erkrankung von Mäusen. Das Borna disease Virus (BDV) kann sich im ZNS der Maus vermehren, löst aber in den meisten Mausstämmen keine Erkrankung aus. …
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Optimization and toxocologic effects of cancer immuno-electrogene therapy using a tumor-targeted interleukin-12 gene construct
… therapy (EGT) of a tumor-targeted version of interleukin-12 (IL-12) in mice. Intralesional bleomycin (BLM) and feline interleukin-12 (fIL-12) DNA injection combined with trans-lesional EP resulted in complete cure of two recurrent oral squamous cell carcinomas and an acanthomatous …
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Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… development. For instance, the innate cytokines interleukin 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell differentiation are relatively well-understood, the role of …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… responses. For example, the innate cytokines Interleukin-12 (IL-12) and type I interferon (IFN-a/b) are induced to high levels by intracellular bacterial and viral infections and have been shown to promote adaptive T lymphocyte responses to infection. While the role for IL-12 on the …
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Equine interferon-gamma and associated cytokines
… medied immune responses. In a broader sense, interleukin-12 and interleukin-18 can also be classified as type I cytokines in as much as they are able to shift the CD4+ cytokine expression pattern to a Thl phenotype and specifically stimulate IFN-γ production not only by T helper cells, but …
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Dendritic cells activated by CpG motifs are potent inducers of a Th1 immune response that protects mice against leishmaniasis
… observed that the availability of the cytokine interleukin-12 at the time of vaccination was a key requirement, but that the source of this cytokine is not the donor cells but unidentified cells from the recipients.
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Dendritic cell maturation and activation via RNA/DNA danger signals : co-delivery of protein antigen with siRNA or CpG DNA
… via enzyme-linked immunosorbent assays for interleukin 12 and interferon-[alpha], respectively, that DCs were activated by CpG oligonucleotide- and siRNA-functionalized nanoparticles [approx.]10-fold more potently than by soluble CpG or siRNA ligands.
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
… Mfs. Although tumor-derived factors, including interleukin-10 and transforming growth factor-b1, modulate Mf response to activation signals, paclitaxel partly reverses tumor-induced Mf-mediated suppression of T-cell reactivity through enhanced production of the immunostimulatory cytokine …
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Alpha-Fetoprotein-spezifische Immuntherapie des hepatozellulären Karzinoms mittels DNA-Immunisierung
… Effekte der mAFP/Zytokin-Koimmunisierung mit Interleukin-12 (IL-12), Interleukin-18 (IL-18) u. Granulozyten-Makrophagen-Kolonien-stimulierendem Faktor (GM-CSF) untersucht. Dabei wurde die DNA sowohl mittels „Gene Gun“ als auch i.m. appliziert. So konnte die immunologische Ignoranz gegenüber …
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Identification of toxoplasma gondii genes involved in the strain-specific modulation of IL-12 cytokine secretion
… by the stimulation of high levels of interleukin- 12 (IL- 12), followed by the production of interferon-y (IFN-y) by immune cells. Although IFN-y is the main mediator of resistance to Toxoplasma infection, Toxoplasma is able to manipulate the immune response through the regulation of …
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Characterization of an IL-12-driven Anticancer Response, and the CD4+ CTL Population Incited, in a Murine Model of Leukaemia
… as the quintessential Th1 polarizing cytokine, interleukin-12 (IL-12) holds much promise; however, optimal therapeutic protocols have yet to be developed and clinical results have fallen short of this promise. The in vivo IL-12 experiments described here highlight a characteristic of cellular …
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A materials-based approach for localized delivery of cancer immunotherapy
… in the clinic. Inflammatory cytokines such as interleukins-2, 12 and 15 promote potent anti-tumor immunity, but systemically administered cytokines are also highly toxic. In this thesis, we engineered cytokines with a peptide tag containing multiple phosphoserine (pSer) residues, through …
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Analysis of Porcine Immunity in PRRS Virus
… affect secondary immune responses to PRRSV. Interleukin-12 (IL-12) was shown to increase; whereas, EL-10 decreased the frequency of memory IFN-gamma-secreting cells responding to recall viral antigen in vitro. Moreover, co-administration of soluble recombinant IL-12 protein or plasmids …
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Delineating The Roles of IL-12 and IL-23 Produced by Dendritic Cells in Eliciting CD8+ T Cell Resonses Against Listeria Monocytogenes
Interleukin-12 family members are important links between innate and adaptive immunity. IL-12 drives Th1 responses by augmenting IFN-γ production – key for clearance of intracellular pathogens. IL-23 promotes the development of IL-17 producing CD4+ T cells that participate in the control of …
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Endovascular trophoblast cell behavior in normal and abnormal pregnancy
… on days 8-11, rats had smaller placentas at day 12 and increased fetal resorption rate at day 20. The effects of interleukin-12 (IL-12) was also examined on days 8-11. While placental development was normal at both days 12 and 20, fetuses were significantly smaller at day 20. To remedy the …
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Interaktion von Masernviren mit humanen Dendritischen Zellen
… beeinflussten zudem die Sekretion von Interleukin 12 (IL-12), das als ein Schlüsselzytokin für die Polarisierung von T-Zellantworten angesehen wird. Infektionen mit einem prototypischen MV-Vakzinestamm (ED-B) führten unter allen Stimulationsbedingungen zu einer Hemmung oder deutlichen …
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Chitosan Decontamination with Non-Thermal Nitrogen Plasma to Enable Internal Use
… dramatically enhanced anti-tumor properties of interleukin-12 (IL-12). We found that bladder tumors regressed – and mice survived to 90 days – in 88% (n=16) and 92% (n=12) of C57Bl/6 mice treated with unsterile chitosan+IL-12 and plasma-sterilized chitosan+IL-12, respectively, but only 8% (n=12) …
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