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Showing 1 to 20 of 33 for “"interleukin-10 (IL-10)"”.

  1. Study and Therapeutic Interference of T Cell Function in Pressure Overload-induced Heart Failure

    Martini, ElisaThe Open University2017

    Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. We attempted to identify and exploit better targets in cardiac …

    the-open-u Repository record

  2. Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages

    Smith, Tyler Joseph

    <p>Interleukin-10 (IL-10) is an important anti-inflammatory cytokine acting to dampen macrophage activation during and after the immune response to microbial pathogens. During the innate immune response to gram-negative bacteria, macrophages are triggered to produce numerous pro-inflammatory …

    mo-state Repository record

  3. Role of PI3K and MAPK in Regulating the IL-10-Induced Temporal Transcriptional Program in LPS-Triggered Macrophages

    Dillow, Amanda Fields

    … a prolonged inflammatory state, the cytokine interleukin-10 (IL-10) induces expression of a set of anti-inflammatory genes that act to inhibit expression of TLR-induced pro-inflammatory genes. While many of the IL-10-induced genes can be induced by IL-10 stimulation alone, some others, such as …

    mo-state Repository record

  4. Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells

    Chrisikos, Taylor, <p>0000-0001-8966-4046</p>2022

    … (STAT3) mediates the intracellular signaling of interleukin 10 (IL-10), an immunosuppressive cytokine. Therefore, we hypothesized that STAT3 and IL-10 inhibit cDC1 function and induction of T cell-mediated immunity. Herein, we show that IL-10 inhibits polyinosinic:polycytidylic acid (poly …

    uthsc Repository record

  5. Regulation of Synergistic Inducible ABIN-3 Gene Expression in Response to IL-10 and LPS

    Peterson, Brian A.

    … genes in response to the host cytokine Interleukin-10 (IL-10). The mechanisms by which IL-10 acts to restrain pro-inflammatory signaling remain incompletely defined. Previously, we identified ABIN-3 as an IL-10-inducible gene capable of inhibiting the action of the pro-inflammatory …

    mo-state Repository record

  6. Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms

    정, 재연2011

    … of tumor necrosis factor-a (TNF-α) and interleukin-10 (IL-10) gene promoter. We studied 412 Korean patients with HBV infection (72 inactive carriers, 261 chronic hepatitis, 79 liver cirrhosis) and 204 healthy individuals who recovered from HBV infection. We assessed polymorphisms in …

    ajou Repository record

  7. Evaluation of Pgg-Glucan, a Novel Immunomodulator, in in Vitro and Ex Vivo Models of Equine Endotoxemia

    Sykes, Benjamin WilliamVirginia Tech2003

    … in four groups; saline control, endotoxin (LPS) (100 ng/ml), PGG-Glucan (0.1, 1.0, 10 and 100 μg/ml) and LPS (100 ng/ml) plus PGG-Glucan (0.1, 1.0, 10 and 100 μgg/ml). Supernatants were collected at 0, 6 and 12 hours and assayed for tumor necrosis factor £\ (TNF£\) activity. Part 2; Horses …

    vt Repository record

  8. Suppressive Effects of Transforming Factor-β and Interleukin-10 on the Cytolytic Activity of Murine Macrophages and Reversal by Cytokines

    Lin, Chin-Hung

    … of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) on peritoneal macrophage killing of H238 target cells and the potential for reversal of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of naive and peptone-activated …

    loma-linda Repository record

  9. Targeting gene therapy to neuroinfalmmatory lesions in experimental autoimmune encephalomyelitis

    Rochford, Christian2012

    … bei gesunden Mäusen eine Aufnahme nur in der Milz und im Knochenmark stattfand. Die Zellen, die in die Entzündungsläsionen im Rückenmark aufgenommen wurden, hatten einen niedrigen CD45-Expressionsgrad und 68% zeigten eine positive Färbung für Isolektin-B4, was auf einen Mikroglia-Phänotyp …

    goettingen Repository record

  10. Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids

    Lacagnina, Michael John2016

    … factors that shape an individual’s susceptibility or resistance to the reinforcing properties of abused substances. Early-life environmental conditions are frequently implicated as critical mediators for later-life health outcomes, although the cellular and molecular mechanisms that underlie …

    duke Repository record

  11. Enhancing Seafood Quality and Safety by Reducing Reliance on Antibiotics: Applying a Novel Antibody in Tilapia

    Garry, Jordan NicoleVirginia Tech2018

    … for the bacterial pathogen, Aeromonas hydrophila, in tilapia. The tilapia were on an anti-interleukin-10 antibody diet as a neutralization of interleukin-10 (IL-10), an anti-inflammatory cytokine. The anti-inflammatory function of IL-10 has been shown to allow persistence of gastrointestinal …

    vt Repository record

  12. Role of autocrine growth factors in the tumorigenic transformation of T cells

    Hassuneh, Mona RushdiVirginia Tech1996

    … resulting from constitutive expression of interleukin-2 (IL-2) and interleukin 2 receptor (IL-2R) genes. Such cell lines could induce tumors <i>in vivo</i> and furthermore, the growth of such transformed cells both <i>ex vivo</i> and <i>in vivo</i> could be inhibited by monoclonal …

    vt Repository record

  13. The influence of equine bone marrow derived stem cells on the response of cultured peripheral blood mononuclear cells to endotoxin

    MacDonald, Elizabeth StewardVirginia Tech2015

    … of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), and interferon gamma (IFN-γ) were determined by ELISA. The immunogenic properties of MSCs were assessed with a one-way mixed lymphocyte reaction. In addition, the ability of MSCs to alter production of …

    vt Repository record

  14. IL -10 gene therapy for the treatment of pulmonary inflammation

    Dokka, Sujatha2019

    Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays an important regulatory role in inflammatory diseases. The overall goal of this research is to investigate the potential therapeutic effect of IL-10 gene therapy for the treatment of pulmonary inflammation and to develop appropriate …

    wvu Repository record

  15. Effects of Antioxidant Supplementation with Vitamin E and Selenium on Cytokine Production in Mice Infected with Trypanosoma Cruzi

    Chen, Dong

    … selenium at levels well above the recommended daily allowance for these two substances results in significantly decreased parasitemia levels and increased longevity. However, the mechanistic role of the antioxidants in this process is not well understood. It is known that vitamin E and selenium …

    wku-diss Repository record

  16. The effect of manipulating apoptotic cell uptake on their immunogenicity

    Attfield, Kathrine ElizabethUniversity of Southampton2009

    Failure of the immune system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours. Apoptotic cells are cleared rapidly by professional phagocytes thus preventing the release of potentially …

    soton Repository record

  17. Association Between Obesity, Depression, and Inflammation Among Seventh-day Adventists in the Biopsychosocial Religion and Health Study

    Paalani, Michael

    … and waist circumference (WC) measurements, while the Center for Epidemiological Studies Depression Scale 11-item short form was used to measure depression. Enzyme linked immunosorbant assays were utilized to measure the serum concentrations of c-reactive protein (CRP), interleukin-6 (IL-6), …

    loma-linda Repository record

  18. Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS

    Setter, Deborah Olmstead2017

    … more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal survival after injury. This study first investigated the roles of IL-10 …

    iupui Repository record

  19. The Role of Histone Deacetylases in Cytokine Regulation in Human Gestational Tissues

    Munro, SherylResearchSpace@Auckland2013

    … cytokine expression and production by placental villous explants in vitro. Term explants were maintained at a physiologically relevant oxygen tension with/without an inflammatory stimulus and/or histone deacetylase inhibitor. In the presence of an inflammatory stimulus, HDAC inhibition resulted in …

    auckland-ms Repository record

  20. Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10

    Schönbein, Christiane2003

    Interleukin-10 (IL-10) ist ein pleiotrophes Zytokin, das von einer Vielzahl von Immunzellen gebildet wird. Im Rahmen einer Immunantwort verändert IL-10 die Expression von löslichen Mediatoren und von Zelloberflächenmolekülen in einer Weise, die zur Eindämmung einer Entzündung führt, bei …

    tu-berlin Repository record

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