Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 80 for “"interleukin-10"”.
-
Psychoneuroimmunology of Interleukin-10
… homeostasis. Pro-inflammatory cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha, arising from disease processes, can activate the hypothalamic-pituitary-adrenal (HPA) axis. Interleukin-10, as a prominent anti-inflammatory cytokine in the immune system, has been shown …
-
Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10
Interleukin-10 (IL-10) ist ein pleiotrophes Zytokin, das von einer Vielzahl von Immunzellen gebildet wird. Im Rahmen einer Immunantwort verändert IL-10 die Expression von löslichen Mediatoren und von Zelloberflächenmolekülen in einer Weise, die zur Eindämmung einer Entzündung führt, bei …
-
Metabolomic analysis of the interleukin-10-deficient mouse model of Crohn's disease
… of intestinal mucosal immunity. The interleukin-10-deficient (IL10-/-) mouse develops intestinal inflammation with similar characteristics to Crohn’s disease, due to the loss of immune tolerance towards intestinal microbiota. Metabolomic analysis is the study of small molecule …
-
Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… of this study was to determine the effects of interleukin-10 on mast cell development from bone marrow progenitors.Materials and Methods. Unseparated mouse bone marrow cells were cultured in IL-3+SCF, giving rise to mast cells and monocytes/macrophages. The addition of IL-10, and the use of …
-
Modulation of Dendritic Cells with the Interleukin-10 Gene on Polycation-Modified Polymeric Particles
… polymeric particles complexed with interleukin-10 (IL-10) gene to modulate DCs. The delivery systems (designated as PSO10H6 and PLGAO10H6) were formed by coating cationic peptide O10H6 (O: ornithine; H: histidine) on the polystyrene (PS) and poly (lactic-co-glycolic acid) (PLGA) …
-
Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo
… shown to play a role in inflammatory disease. Interleukin-10 can regulate inflammatory responses both in vitro and in vivo, and may be a natural regulator of mast cell activation.Objective: To examine Interleukin-10 mediated regulation of FcεRI expression and related downstream signaling …
-
Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury
… responses through the measurement ofinterleukin-6 and interleukin-10, may allow an early prediction of patient outcome and thelikelihood of developing complications. Blood samples and clinical data were taken on days 1, 3 and 5, with additional clinical datataken on day 8, following …
-
Interleukin-10 und Interleukin-12 produzierende Monozyten-Subpopulationen bei Normalpersonen und Probanden mit atopischer Diathese
… Arbeit wurde die monozytäre Produktion von IL-10 und IL-12 untersucht. IL-12 ist ein proinflammatorisches Zytokin, das die zellvermittelte Abwehr aktiviert und TH1 Immunantworten induziert. IL-10 wirkt antagonistisch zu IL-12, indem es die Synthese zahlreicher Entzündungsmediatoren unterdrückt …
-
Investigating the role that Interleukin-10's receptor binding properties play in defining its biological activities
Interleukin-10 (IL-10) is a key immuno-regulatory cytokine with potent anti-inflammatory effects. IL-10 contributes to immuno-suppression by inhibiting the presentation of antigen and decreasing the production of pro-inflammatory cytokines from innate cells such as dendritic cells and macrophages …
-
Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
… of tumor necrosis factor-a (TNF-α) and interleukin-10 (IL-10) gene promoter. We studied 412 Korean patients with HBV infection (72 inactive carriers, 261 chronic hepatitis, 79 liver cirrhosis) and 204 healthy individuals who recovered from HBV infection. We assessed polymorphisms in …
-
The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… bacterial clearance. In contrast, we show that interleukin (IL)-10 is crucial to counteract the lethal IFN-γ-induced cytokine storm and preserve lung function. Transgenic mice with ablation of the IL-10 receptor α gene in mononuclear phagocytes have significantly higher levels of IFN-γ and …
-
Suppressive Effects of Transforming Factor-β and Interleukin-10 on the Cytolytic Activity of Murine Macrophages and Reversal by Cytokines
… of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) on peritoneal macrophage killing of H238 target cells and the potential for reversal of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of naive and peptone-activated …
-
Assoziation von Genpolymorphismen der 5 flankierenden Region des Interleukin-10-Gens auf das Überleben oder die Remissionsrate beim aggressiven Non-Hodgkin-Lymphom
… Die Expression und Ausschüttung des Zytokins IL-10 ist beim Non-Hodgkin-Lymphom dereguliert. Die Vorgänge der Deregulierung des Immunsystems bei Lymphomerkrankungen und deren Auswirkung auf den klinischen Verlauf sind noch ungenügend verstanden. In dieser Arbeit wurde untersucht, inwieweit …
-
Charakterisierung von Monozyten anhand ihrer Interleukin-10-Produktion und Darstellund der Existenz funktionell unterschiedlicher Subpopulationen (M1/M2) analog den Th1/Th2-Schema
… aus dem Blut gesunder Spender anhand ihrer IL-10-Produktion separiert und anschließend näher charakterisiert. Fragestellung der Arbeit war, ob sich IL-10 produzierende Monozyten funktionell different von der nicht IL-10 produzierenden Subgruppe unterscheiden. Da Vorarbeiten nahe legten, dass …
-
The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… in skin immune responses. In conclusion, IL-10 family members can have both beneficial and destructive effects on the skin organ depending on the micro milieu and cell-type involved. Manipulating the balance of IL-10 family members in the skin may offer new therapeutic approach for both …
-
Einfluss von septischem Plasma und intensivmedizinischen Medikamenten auf die Zytokin- und Procalcitoninfreisetzung von in vitro stimulierten PBMC septischer Patienten und immunkompetenter Probanden
… die proinflammatorischen Zytokine TNF-alpha, Interleukin-6 und Interferon-gamma, auf der anderen Seite Interleukin-10, dem antiinflammatorische Eigenschaften zugesprochen werden, und Procalcitonin.
Page 1 of 4