Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"interleukin-1 (IL-1)"”.
-
Interleukin-1 (IL-1) as a potential contributor to the pathophysiology of Alzheimer's Disease
<p>Elevations of the pro-inflammatory cytokine interleukin-1 (IL-1) have been reported as part of the inflammatory response to injury and neurodegenerative disorders. The observation of increased IL-1 levels in the brains of patients with Alzheimer's disease (AD) triggered over two decades of …
-
The Effect of Interleukin-1 (IL-1) Concentration on Single Cell NF-kappaB Activation in a Gradient-Generating Microfluidic Device
Interleukin-1 (IL-1) is a multifunctional cytokine produced primarily by activated monocytes/macrophages and by a variety of other cell types. IL-1 plays an integral role in the immuno-inflammatory response of the body to a variety of stimuli including infection, trauma and other bodily injuries. …
-
An Evaluation of Two Interleukin-1 Assays
Interleukin-1 (IL-1) is produced by macrophages and has been shown to be an important protein involved in the regulation of an immune response. Several methods of detecting IL-1 in the supernatant of macrophage cultures have been developed. The purpose of this project was to evaluate two of these …
-
Murine Peritoneal Macrophage Response to Colonial Phenotypes of Candida Albicans
The ability of Candida albicans to change from yeast to mycelial form has been associated with pathogenicity of the organism. High frequently switching is a phenomenon that occurs spontaneously and has been documented in clinical isolates from oral and vaginal candidiasis. Because switched …
-
Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
The cytokines interleukin-1 (IL-1) and interleukin-6 (IL-6) are produced during an immune reaction and cause inflammation and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile …
-
The Effect of Adenosine on the Production of Inflammatory Mediators By Macrophages in Response to Candida Albicans
… tumor necrosis factor alpha (TNF-α) and interleukin 1 (IL-1). Adenosine is an important physiological molecule that can modulate the function of macrophages by altering the amounts of cytokine produced. The effect of adenosine on the production of TNF-α and IL-1 by peritoneal macrophages …
-
Klonierung und Charakterisierung des Interleukin-1beta-Systems im Gehirn von Callithrix jacchus
Als neues Tiermodell zur Untersuchung des Interleukin-1b-Systems im Gehirn wurde die Gattung der nichtmenschlichen Primaten Callithrix jacchus ausgewählt.In der vorliegenden Arbeit wurde zunächst erstmals der Einfluß der künstlichen Stressung mittels Lipopolysaccharid (LPS) und deren Auswirkung auf …
-
Effects of sodium hyaluronate and triamcinolone acetonide on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1
… chondrocyte proteoglycan catabolism caused by interleukin-1 (IL-1) administration. Chondrocytes were collected from fetlock joints of ten horses euthanized for reasons unrelated to joint disease. Chondrocyte pellets were treated with media (negative control); media containing IL-1 only …
-
The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review
… tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis …
-
Purification of SIMPL Antibody and Immunofluorescence of SIMPL Sub-Cellular Localization in Response to TNFα- and IL-1
… In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal through the IL-1 and TNF-α receptors, respectively, which are found on various cell types. Activation of these receptors can result in the nuclear localization of NF-κB where it enables the …
-
The role of type I interferon in chronic lymphocytic leukemia
… of a phase I clinical trial of the recombinant interleukin-1 (IL-1) receptor antagonist anakinra in CLL patients. Anakinra was found to upregulate IFN-signaling, decrease oxidative stress, and reduce nuclear factor kappa light chain enhancer of activated B cells (NFκB) signaling within CLL cells …
-
Cytokines and chemokines in the pathogenesis of low back pain
… mediate the processes that lead to structural failure, as seen in IVD degeneration. Cytokines are implicated in this process, several studies have identified that Interleukin-1 (IL-1) and Tumour Necrosis Factor-α (TNF-α) expression is increased in degenerate IVDs compared to their normal …
-
Interleukin-1 receptor antagonist delivery through adenoviral mediated gene transfer as a treatment for equine joint disease
The interleukin-1 (IL-1) system is a small group of cytokines composed of two agonist proteins and a receptor antagonist (IL-1Ra). The action of the IL-1 system is mediated through binding of these ligands to the IL-1 receptors. Binding of the IL-1Ra protein to IL-1 receptors has not been …
-
Studies of the role of nf-κb in controlling osteoclast differentiation and bone loss
… factors through induction of NF-κB RelB; 2) Similar to RANKL, TNF sequentially activates transcriptional factors NF-κB p50 and p52 followed by c-Fos and then NFATc1 to induce OC differentiation. However, TNF alone nduces very limited OC differentiation. In contrast, it pre-activates OCPs to …
-
Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
Articular cartilage functions to reduce the mechanical stresses associated with diarthrodial joint movement, protecting these joints over a lifetime of use. Tissue function is maintained through the balance between synthesis and resorption (i.e., metabolism) of extracellular matrix (ECM) by …
-
Die Rolle des Tumorsuppressors p53 für die TNF-alpha-vermittelte Induktion des MCP-1-Gens
… sind entscheidend an der Immunantwort beteiligt und bekannt für ihre Effekte bei der Anlockung und Aktivierung spezifischer Gruppen von Leukozyten. Das "Monocyte-Chemoattractant-Protein-1" (MCP-1/CCL2) ist ein wichtiges Mitglied der Chemokin-Familie und löst die Infiltration von …
-
Even a little is too much: A longitudinal study of weight gain in the cat
… glutathione peroxidase, superoxide dismutase, interleukin-6 (IL-6), Interleukin-1 (IL-1), tumor necrosis factor alpha (TNF-alpha), respiratory exchange ration (RER), and heat production. Body mass index (BMI), girth, total fat, and energy intake increased significantly with increasing body …
-
Recombinant Equine Interleukin-1 Induced Models of Equine Joint Disease
Osteoarthritis (OA) is a debilitating disease of joints that afflicts horses of all ages and breeds and can result in lameness, suboptimal performance, and decreased quality of life. The pro-inflammatory cytokine interleukin-1 (IL-1) has been associated with the initiation and pathogenesis of joint …
-
Viral Delivery of the Fat-1 Gene to Treat Post-Traumatic Arthritis with Diet-Induced Obesity
… levels of pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α,) are more elevated than in non-obese individuals. The role of fatty acids, obesity, and PTA has been examined, with omega-3 fatty acids showing promise as an anti-inflammatory after injury …
-
The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… associated with increased levels of cytokines (interleukin-1 (IL-1) and tumour necrosis factor (TNF)), platelet activating factor (PAF), activated complement (C3a, C5a) and norepinephrine in the blood. Activated complement, IL-1, TNF and PAF are known to activate polymorphonuclear leukocytes …
Page 1 of 2