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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 51 for “"interleukin- 1β"”.

  1. Studies on the novel inhibitors of interleukin-1β converting enzyme from microbial sources

    Koizumi, FumitoKyoto University2005

    kyoto Repository record

  2. Atypical Mechanisms of Synthesis, Activation and Release of Interleukin-1β from Vascular Smooth Muscle Cells

    Morales Maldonado, Maria AlejandraUniversity of Cambridge2020

    … atherosclerosis in humans and animal models. IL-1β is a potent inflammatory cytokine implicated in atherogenesis and other vascular diseases. However, control of its activation and release has been predominantly studied in macrophages, with scant data on whether vascular smooth muscle cells …

    cambridge Repository record

  3. Molecular Mechanisms Involved in Interleukin-1β Release by Macrophages Exposed to Metal Ions from Implantable Biomaterials

    Ferko, Maxime-AlexandreUniversité d'Ottawa / University of Ottawa2018

    … 3 (NLPR3) inflammasome, which is responsible for interleukin(IL)-1β production through caspase-1. Furthermore, these ions are known to induce oxidative stress, and inflammasome priming is known to involve nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling. However, …

    ottawa-retro Repository record

  4. Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β

    Brigman, Brian E.Creighton University2000

    The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading of bones in vivo include bone formation, though it is unclear if this …

    creighton Repository record

  5. Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-κB and p38

    Hiramitsu, TerukoKyoto University2006

    kyoto Repository record

  6. The effect of glibenclamide on the pathogenesis of melioidosis

    Koh, Gavin Christian Kia WeeUniversity of Cambridge2012

    … that the effect of glibenclamide was specific to interleukin-1β secretion. This reduction in interleukin-1β secretion was associated with reduced cellular influx into the lungs as well as lower bacterial loads in blood, liver and spleen.

    cambridge Repository record

  7. The biogenesis of erythropoietin during inflammation

    Leng, Henry Martin JohnDivision of Clinical Pharmacology1995

    … anaemia. Macrophage-conditioned medium, interleukin-1β, interleukin-6, tumour necrosis factor-α, and neopterin were assayed for inhibition of erythropoietin synthesis by HepG2 cells in culture. All, except neopterin, effected dose-dependent reductions in the secretion of the hormone. …

    cape-town Repository record

  8. The study of the role of mast cells in malignant pleural effusion

    Γιάννου, Αναστάσιος2018

    … this, mast cells secreted tryptase AB1 and interleukin-1β, that, in turn, potently triggered vascular hypermeability and tumor cell nuclear factor-κΒ activation, respectively. cKIT inhibitor imatinib mesylate was effective against effusion development, indicating that mast cell-dependent …

    patras-thes Repository record

  9. Respiratory muscle work and inspiratory muscle training on cytokines, oxidative stress and diaphragm fatigue in younger and older populations

    Mills, DENottingham Trent University2013

    … respiratory muscle work also elevates cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) within the respiratory muscles and systemically. There is mounting evidence that inflammation contributes significantly to the ageing process and age related diseases. Enhanced oxidative stress, …

    nott-trent Repository record

  10. The Skin Remembers: Epigenetic Memories of Inflammation Past

    Larsen, Samantha B

    … AIM2, and its downstream effectors caspase-1 and interleukin-1β. Characterization of the chromatin landscape in inflammation-experienced EpSCs reveals specific retention of monomethylation of histone 3 on lysine 4 in memory chromatin domains primed for reactivation. Altogether, this body of work …

    rockefeller Repository record

  11. Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation

    김, 보경2011

    … cytokines, tumor necrosis factor α and interleukin-1β.These results suggest that PIP5KIα may act as a regulator of brain inflammation by modulating NF-κB signaling.

    ajou Repository record

  12. Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes

    Lucero, JacquelynnTexas Woman's University2019

    … for 24 h then stimulated with the recombinant interleukin-1β (20 ng/mL) for 24 hours. After an initial increase (p<0.05) in cell proliferation at 1.25 µg/mL TCP, a dose-dependent decrease in cell proliferation was observed with higher doses of TCP. Following a significant decrease in nitrate …

    twu Repository record

  13. HIV prophylaxis: an essential role for T cells and adjuvants in recombinant mucosal Lactobacillus acidophilus vaccines

    LeCureux, Jonathan Spicer, author, Dean, Gregg, advisor, Aboellail, Tawfik, committee member, Chen, Chaoping, committee member, Zabel, Mark, committee memberColorado State University. Libraries2016

    … strains along with strains expressing adjuvants (interleukin-1β or flagellin) to improve immunogenicity against the HIV MPER. We compared the adjuvant strains to the MPER-only strain by oral administration in BALB/c mice to observe these improvements, and in CD40L-/- mice to observe if T cell help …

    colostate Repository record

  14. Association of the Interleukin-1 beta and Interleukin-1 Receptor Accessory Protein Gene Polymorphisms with Persistent Hepatitis B Virus Infection and Hepatocellular Carcinoma

    김, 순선2011

    … are probably related to host immune factors. Interleukin-1β (IL-1β) plays significant roles in inflammation and immune defense via IL-1 receptor accessory protein (IL-1RAcP). We investigated whether genetic polymorphisms of IL-1B and IL-1RAcP genes are associated with persistent HBV infection …

    ajou Repository record

  15. Anti-Inflammatory Effect of Berry Essences

    Gu, Inah2019

    … nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which accelerate the development of other chronic diseases. Accordingly, targeting these pro-inflammatory factors is one of the important roles for anti-inflammatory …

    arkansas Repository record

  16. Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches

    Frigerio, FedericaThe Open University2017

    … epileptogenesis and in human epilepsy. Interleukin-1β (IL-1β)/IL-1Receptor type 1 (IL-1R1) and High Mobility Group Box 1 (HMGB1)/Toll-like Receptor 4 (TLR4) axes are key initiators of neuroinflammation following epileptogenic injuries. Experimental and clinical evidence showed that …

    the-open-u Repository record

  17. The role of purinergic receptors in the modulation of JNK signalling endothelial and cancer cells

    Yeun, PeiUniversity of Strathclyde2012

    … including tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β).3,4 Thus, this project examined the potential for purinergic and cytokine receptors to interact at the signalling level. In particular, it was hypothesised that purinoceptors could inhibit cytokine induced JNK signalling. In …

    strathclyde Repository record

  18. The Effects of Long Term Walnut Consumption on Levels of Plasma Tocopherols and Inflammatory Mediators

    Sapwarobol, Suwimol

    … of tocopherols and the inflammatory mediators interleukin-1β (IL-1β ), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and Creactive protein (CRP) in healthy participants. Ninety participants were recruited into a 12-month randomized crossover intervention study, which consisted of two …

    loma-linda Repository record

  19. Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic

    Perez, Damon Scott, author, Campain, Julie, advisor, Yang, Raymond Shih-hsien, 1940-, advisor, Legare, Marie E., committee member, Fox, Michael, committee member, Ranu, Rajinder S., committee memberColorado State University. Libraries2005

    … genes include; α-integrin binding protein-63, interleukin-1α, interleukin-1β, Ras guanyl releasing protein-1, retinoic acid- and interferon-inducible protein, and YY1-associated factor-2. Arsenic altered the expression of genes involved in cell cycle checkpoint regulation. These genes include; …

    colostate Repository record

  20. Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells

    Ruhl, Elizabeth2015

    … anti-CD3 monoclonal antibody (mAb) plus interleukin-2 (IL-2), or 2) cis costimulation using beads carrying co-immobilized anti-CD3 and anti-CD28 mAbs. By cross-linking the CD3 and CD28 receptors, these mAbs mimic in vivo signaling events, leading to cytokine production and proliferation. …

    wayne-thes Repository record

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