Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1005 for “"interleukin"”.
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
Intrahepatic cell-derived IL-17 and IL-22 are important for T cell priming and hepatoprotection in viral hepatitis, respectively; however, the source and regulation of these cytokines in the liver microenvironment are not well defined. Here, we present evidence for a significant expansion of IL-17- …
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Psychoneuroimmunology of Interleukin-10
… homeostasis. Pro-inflammatory cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha, arising from disease processes, can activate the hypothalamic-pituitary-adrenal (HPA) axis. Interleukin-10, as a prominent anti-inflammatory cytokine in the immune system, has been shown …
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Vergleich der Signaltransduktion von Interleukin-6 und Interleukin-10 in primären humanen Makrophagen
… mechanisms in primary human macrophages. Interleukin-10 (IL-10) acts on human macrophages as a more potent anti-inflammatory cytokine than interleukin-6 (IL-6) although both cytokines signal mainly via activation of the transcription factor STAT3. In this study I compared IL-10 and IL-6 …
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Detection of glial interleukin-6 release: Development of a novel interleukin-6 Elisa
The development of an interleukin-6 (IL-6) enzyme-linked immunosorbent (ELISA) assay resulted in a detection range of 1 ng/m1 to 10 ng/mL IL-6. The limit of detection (LOD) for IL-6 was 0.25 ng/mL. Troubleshooting techniques were attempted including matrix effects, non-specific binding, and coating …
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Chemokinaktivität induziert durch Interleukin-6
Interleukin-6 belongs to the IL-6 type cytokine family. It signals through a receptor complex composed of the IL-6Ralpha and the signal-transducing subunit gp130. The activation of this receptor complex leads to the activation of the JAK/STAT pathway, the MAPK- and PI3K-caskade. IL-6 plays an …
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Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury
… responses through the measurement ofinterleukin-6 and interleukin-10, may allow an early prediction of patient outcome and thelikelihood of developing complications. Blood samples and clinical data were taken on days 1, 3 and 5, with additional clinical datataken on day 8, following …
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… pathogenesis of NP. Especially the regulation of interleukin-5 (IL-5) and the interleukin-5 receptor α (Rα) isoforms were studied with emphasis on future therapeutic strategies in NP. Characterisation of NP suggests a central deposition of plasma proteins (albumin), regulated by the subepithelial, …
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Interleukin-10 und Interleukin-12 produzierende Monozyten-Subpopulationen bei Normalpersonen und Probanden mit atopischer Diathese
Durch Freisetzung regulatorischer Zytokine können Monozyten Immunreaktionen beeinflussen. In dieser Arbeit wurde die monozytäre Produktion von IL-10 und IL-12 untersucht. IL-12 ist ein proinflammatorisches Zytokin, das die zellvermittelte Abwehr aktiviert und TH1 Immunantworten induziert. IL-10 …
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
Interleukin-1α (IL-1α) is a potent cytokine involved in a range of diseases and can be found expressed on the cell surface (csIL-1α) and in the soluble form, signalling through the type I IL-1 receptor (IL-1R1). IL-1 signalling leads to increased secretion of cytokines, recruitment of immune cells …
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Bedeutung von Interleukin-6, Oncostatin M und Interleukin-31 für die biochemische und immunologische Barrierefunktion der Haut
… of this thesis we investigated the effect of interleukin-6 (IL-6) and oncostatin M (OSM) on the expression of MRP-1, -3, -4 and -5 in normal human epidermal keratinocytes and primary dermal fibroblasts. Using real-time PCR, RT-PCR, cDNA microarray, immunostaining and efflux assays we found …
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Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem : lokale Applikation d. Designerzytokins Hyper-Interleukin-6 im adulten Organismus d. Ratte u. Auswirkungen v. exzitatorischen Neurotoxinen im Interleukin-6 transgenen Mausmodell
… Expression des Designerzytokins Hyper-Interleukin-6 (H-IL-6) im <br>Zentralnervensystem (ZNS) entwickelt. H-IL-6 besteht aus humanem Interleukin-6 (IL-6) verbunden mit löslichem IL-6 Rezeptor (sIL-6R). Erstmalig wurden hierfür makroverkapselte, H-IL-6 exprimierende Maus-Melanomzellen …
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Spezifische Hemmung der allergieassoziierten Interleukin-4 Signaltransduktion
Das Cytokin Interleukin-4 (IL-4) ist ein essentieller Faktor bei der Entstehung von Sofort-Typ Allergien. Die Bindung von IL-4 an seinen Rezeptor und die anschließende Phosphorylierung des IL-4 aktivierten Transkriptionsfaktors Stat6 ist ein Schlüsselereignis bei der allergischen Immunantwort. In …
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Tissue specific genetic regulation of Interleukin 6
Interleukin 6 (IL6) is associated with arterial disease development, progression and surgical outcome. Raised levels of IL6 may play a causal role in disease development or may be the effect of pathology. An IL6 single nucleotide polymorphism (SNP) G- 174C has been identified and reported to …
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An Evaluation of Two Interleukin-1 Assays
Interleukin-1 (IL-1) is produced by macrophages and has been shown to be an important protein involved in the regulation of an immune response. Several methods of detecting IL-1 in the supernatant of macrophage cultures have been developed. The purpose of this project was to evaluate two of these …
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Der Interleukin-1-Genkomplex in der Schizophrenie
… drei genetische Polymorphismen in Genen des Interleukin-1-Genkomplexes auf eine mögliche Assoziation mit Schizophrenie untersucht: die Gene, die für die proinflammatorischen Interleukine Interleukin-1 alpha und Interleukin-1 beta kodieren, sowie das Gen, welches für den antiinflammatorischen …
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Regulation of Adrenal Steroidogenesis by Interleukin-6
Cortisol and dehydroepiandrosterone (DHEA) are steroids produced by the zona fasciculata (ZF) and reticularis (ZR), respectively, of the adrenal cortex. Both steroids are upregulated in response to adrenocorticotropic hormone (ACTH). Cortisol is a glucorticoid that is important in the regulation of …
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