Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"interictal"”.
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The Interictal State In Epilepsy And Behavior
… of abnormal activity between seizures, known as interictal spikes. Interictal spikes have thus far been poorly researched, yet growing evidence supports an important role for them in epilepsy. In this project, we first show the high variability between reviewers in marking interictal spikes on …
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Linking Molecular, Electrical And Anatomical Properties Of Human Epileptic Brain
… in between seizures, and referred to as `interictal' spikes. Interictal spikes occur far more frequently than seizures and in most epilepsy cases, cannot be associated with a clinical symptom. There is growing evidence supporting the role of interictal spikes in seizures and epilepsy. We …
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Evaluation of Neurofilament Light Chain as a Biomarker in Dogs with Structural and Idiopathic Epilepsy
… dogs with idiopathic epilepsy regardless of the interictal interval. Serum NfL concentration was significantly increased in dogs with structural epilepsy when compared with dogs with idiopathic epilepsy (p < 0.001). There was no significant difference in NfL concentration in dogs with an …
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High frequency activity preceding epileptic seizures
… population spikes lasting ~46 sec) and interictal discharges (abrupt potential deflections, ~40 ms) were induced in rat hippocampal slices by increasing potassium concentration in artificial cerebrospinal fluid (8-10 mM, ACSF). We demonstrated that 1) the HFA was formed mainly by …
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El péptido en relación con el gen de la calcitonina como potencial biomarcador de migraña crónica
… niveles de CGRP en sangre periférica en periodo interictal. Posteriormente, un subgrupo de pacientes con MC recibió tratamiento con onabotA (al menos 2 ciclos con una periodicidad trimestral) de acuerdo con las indicaciones del estudio PREEMPT. En este subgrupo de pacientes se procedió a la …
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3-Dimensional Intracortical Neural Interface For The Study Of Epilepsy
… hypothesis of this project is that electrical interictal activity is generated in a layer- and lateral-specific pattern. </p> <p>This work reports a novel neural probe technology for the manufacturing of 3D arrays of electrodes with integrated microchannels. This new technology is based on a …
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Seizure prediction and control in epilepsy
… of PE to distinguish between preictal and interictal state has been demonstrated using Receiver Operating Characteristics (ROC) analysis. Correlation analysis was used to assess dependency of PE on vigilance states. Scalp EEG-Data from two right temporal epileptic lobe (RTLE) patients and …
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Seizure development in kindling fast and kindling slow rat strains
… observed in the manifestation of spontaneous interictal spikes (IIS). IISs were seen only in the SLOW strain and appeared to correlate positively with kindling development; i.e., higher kindling scores were associated with a higher frequency of IISs. Finally, norepinephrine (NE) levels in …
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Propagation of generalised discharges in idiopathic generalised epilepsy
… onset was 6-45 ms (mean latency 19.2ms). Interictal focal abnormalities were seen in 59 patients (69 %) in addition to the generalised discharges. There was an association between presence of synchronous discharges and one seizure type, and between presence of non-synchronous discharges …
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Time-resolved Resting-state fMRI of Brain States Associated with Drug-resistant Epilepsy
… between the occurrences of iEEG-recorded interictal epileptiform discharges (IEDs) and occupied brain state is examined to better understand how IED activity impacts brain network activity. The findings of this thesis demonstrate the analytical framework’s potential to enhance the …
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Identifying the Seizure Onset Zone using Intracranial EEG-fMRI
… dependent (BOLD) responses associated with interictal epileptiform discharges (IEDs). However, the concordance level between SOZ and IED-related BOLD clusters has not been quantitatively investigated for different brain structures. This thesis aims to identify patient-specific concordance …
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EXPLORING PHYSIOLOGICAL, PATHOLOGICAL AND PARAPHYSIOLOGICAL BRAIN ACTIVITY ACROSS SCALES WITH SIMULTANEOUS INVASIVE AND NON-INVASIVE EEG
… brain activity, specifically focusing on interictal epileptiform discharges (IEDs). These discharges, often difficult to detect with scalp EEG alone, were successfully localized using co-registration. By guiding hd-EEG analysis with SEEG data, hidden epileptic activity was revealed, …
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Computational Approaches To Epilepsy: Graph Networks For Localization And Multi-Model Approach For Prediction
… This approach is validated on challenging interictal recordings, demonstrating that integrating these novel graph features with established biomarkers in a hybrid classifier achieves state-of-the-art performance with 90% accuracy, providing a robust and generalizable tool for pre-surgical …
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NOVEL THERAPEUTIC APPROACHES EMERGING FROM HCN CHANNELS STRUCTURAL AND FUNCTIONAL STUDIES
… electrophysiological recordings reveal increased interictal spike activity in knock-in mice, which is further amplified following lamotrigine administration. Sleep architecture is also disrupted in these animals, suggesting that HCN1 dysfunction impacts broader aspects of brain function beyond …
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Spatiotemporal brain imaging
… I compare the non-invasive MEG localization of interictal spikes with verification from invasive recordings and surgical results. These studies, in both normal volunteers and patients, clearly demonstrate the utility, accuracy, and power of the combined use of fMRI, EEG and MEG. The tools …
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Multi-Modality Assessment Of Language Function
… out with a study exploring the effects of focal interictal epileptiform activity upon ongoing language processes; contributing beyond the neuroscience of language to the epilepsy literature, in honor of the patients providing the data for these studies. Our data demonstrates that such localized …
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The utility of mobile telephone recorded videos as adjuncts to the diagnosis of seizures and paroxysmal events in children with suspected epileptic seizures
… the patient's history. Neurological examination, interictal electroencephalogram and neuroimaging can all be normal in patients with epilepsy. Making the correct diagnosis in patients with suspected epilepsy is often difficult. Studies show that some 30% of patients are incorrectly diagnosed as …
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Kortikale Stromdichterekonstruktion interiktaler epilepsietypischer Aktivität bei Patienten mit Temporallappenepilepsie
In der vorliegenden Studie wurde der Wert der kortikalen Stromdichterekonstruktion in der prächirurgischen Diagnostik von Patienten mit mesialer und lateraler Temporallappenepilepsie zur Lokalisation des epileptogenen Fokus untersucht. Das Verfahren der Stromdichterekonstruktion (mit Minimierung …