Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 81 for “"interferons"”.
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Regulation of type I interferons in murine dendritic cells
… of innate and adaptive immune responses. Type I interferons (IFNs), as important danger signals, activate cDCs through the canonical type I IFN receptor signaling. Type I IFNs are the first line of host defense against viral infection by up-regulating IFN-stimulated genes (ISGs). However, there …
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Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis
… influenza A virus (IAV) infection. IAV induced interferons (IFN) play a crucial role in antiviral immunity. However, recent reports have indicated that influenza-induced IFN-I and IFN- γ signaling suppress innate antibacterial immunity by distinct mechanisms, thereby increasing host …
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Plasmacytoid Dendritic Cells Sense Skin Injury and Promote Wound Healing Through Type I Interferons
Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells, which selectively express intracellular Toll-like receptors (TLR)-7 and TLR-9 and have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing …
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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications
<p>The germ theory of disease, which dictates that microorganisms colloquially referred to as "germs" can invade humans or other hosts and cause disease, has remained the dominant conceptualization of infectious disease since the late nineteenth century. Since that time, growing appreciation for …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
… of EBV, murine herpesvirus 68 (MHV68). Type I interferons (type I IFN) also suppress lytic and latent MHV68 infection, and have been demonstrated to directly and indirectly support antiviral CD8+ T cell development and function in various murine viral infection models. Despite well-established …
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
… innate immune system responsible for inducing interferons and downstream signaling to control viral infection. While much is known about the stimuli-dependent induction of interferons, less is known about the molecular mechanisms responsible for maintaining low basal levels of interferons in …
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Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus
… targeting key immune modulatory factors, such as interferons. In my thesis, I employed both approaches. First, we explored whether exercise training could induce adaptations in bone marrow-derived macrophages, resulting in trained immunity, known to occur in immune cells due to persistent …
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Characterizing the role of thymic interferon in T cell development and selection
Type I and III interferons (IFNs) are robustly induced during infections, where they protect cells against viral infection and activate immune cells. Curiously, both type I and type III IFNs were reported to be produced at low levels in the thymus in the absence of infection – the site of T cell …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… receptor is a cytokine receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative effects, primarily through Jak/STAT signalling. The T-cell receptor is an antigenic receptor that recognises antigenically-derived …
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Die Bedeutung von Interferon alpha und Interferon gamma auf den Verlauf der Marekschen Krankheit beim Haushuhn
… between host and virus needs to be expanded. Interferons are cytokines with antiviral activity. On the basis of their structural and functional features they can be divided into type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) interferons. Type I plays an important role during the early …
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Multiple transducer synthetic aperture sonar interferometry for emulating SAR interferometry
… sonar images as well as multiple-baseline sonar interferons resulting from imaging a variety of scenes are presented in this thesis.
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… (STAT1) and 2 (STAT2) are primarily activated by interferons and play a central role in orchestrating responses to a variety of pathogens by activating the transcription of nuclear encoded genes that mediate antiviral, antigrowth and immune surveillance responses. In addition to their nuclear …
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The regulation and function of viperin during rhinovirus infection
… molecules, including pro-inflammatory cytokines, interferons and interferon stimulated genes. Viperin is one of the most highly upregulated interferon stimulated genes in rhinovirus infected airway epithelial cells. Viperin expression during viral infection has long been associated with direct …
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
… Here, we present evidence that type I interferons (IFN1) receptor signaling in neutrophils and monocytes serves as a universal mechanism that restrict acquisition of suppressive activity by these cells. Downregulation of the IFNAR1 receptor and inactivation of the IFN1 pathway was found …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… of pro-inflammatory cytokines and type I interferons (IFN) through the activation of the transcription factors including IFN regulatory factor 3 (IRF3). Interestingly, we found evidence that the same defense mechanisms are implicated in protecting organisms from cancer. We discovered that …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… activity of immunomodulatory cytokines. </p><p>Interferons are a group of cytokines notable for their ability to shape immune responses. To some extent, this is accomplished through their ability to induce expression of families of GTPases. Herein, I describe my work characterizing the …
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Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer
… to measure inflammation, interleukins (IL), interferons (IFN) and tumor necrosis factors (TNF; IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… defense in response to viral infections. Type I interferons (IFN-α/β) are the major components of the innate immune system, and in turn many viruses have evolved to modulate the host interferon responses. In the present study, the PEDV IFN antagonism was investigated. We found that IFN-β …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… which includes the production of anti-viral interferons. TLRs 3, 4, and 7/8 and the RLR, RIG-I, are the primary PRRs involved in the recognition of RNA viruses and they signal through the adaptors TRIF (TLR3, 4), MyD88 (TLR4, 7/8, 9), and MAVS (RIG-I). The innate response serves to limit …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… TLR-agonists, pro-inflammatory cytokine, or interferons, and CH25H mRNAs expression levels were measured by qPCR. Results In this study, we show that CH25H is induced by Zika virus infection or TLR stimulation. Interestingly, CH25H is induced by pro-inflammatory cytokines including 1L- 1, …
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