Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"interferon-gamma (IFN-γ)"”.
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Interferon-γ aptamers for the diagnosis of extra-pulmonary tuberculosis
… challenging because of the low bacillary burden. Interferon gamma (IFN-γ) has been identified as a promising biomarker for the diagnosis of EPTB. The development of rapid and accurate point-of-care (POC) diagnostic technologies becomes crucial in controlling EPTB. Aptamers referred to as …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… proinflammatory cytokines such as IL-17. While Interferon-gamma (IFN-γ) is traditionally seen as proinflammatory, recent findings highlight a paradoxical protective role by inhibiting Th17 differentiation. In this thesis, we explored how IFN-γ, through its regulation of inducible nitric oxide …
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Small Solutions to Big Problems: Design and Synthesis of Nanoparticles for Biomedical Applications
… functionalized with streptavidin-Cy3, interferon gamma (IFN-γ), and CX3CL1. Poly(methacrylic acid), chitosan, and polyinosinic-polycytidylic acid (poly(I:C)) were successfully adsorbed to the surfaces of nanoparticles to enhance particle stability and targeting. Iron-based coupling …
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The identification and characterization of novel persistence genes in chlamydia trachomatis
… C. trachomatis, a cytokine that is produced is interferon-gamma (IFN-γ). In vitro, IFN-γ stimulates expression of the host enzyme indoleamine 2,3-dioxygenase. This enzyme converts free intracellular tryptophan to N-formylkynurenine. Tryptophan starvation induces C. trachomatis to enter a …
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Neutrophil-Derived IFN-γ in Toxoplasma gondii Infection and Innate Immunity
Interferon-gamma (IFN-γ) is a major cytokine that is critical for host resistance to a broad range of intracellular pathogens. Production of IFN-γ by Natural Killer (NK) and T cells is initiated by the recognition of pathogens through Toll-like receptors (TLRs). In an experimental model of …
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Single-cell Functional Profiling of Lymphocytes for Cancer Immunotherapy
… that CD56dimCD16+ NK cells are immediate interferon gamma (IFN-γ) secretor upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and no evidence of cooperation between NK cells to synergistic activation or faster IFN-γ secretion. These results establish our …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
<p>Interferon-gamma (IFN-γ), a well-studied pro-tumorigenic cytokine in melanoma, has been shown to upregulate programmed death‐ligand 1 (PD‐L1) on the melanoma cell. The interaction between PD-L1 and its receptor PD-1 inactivates T-lymphocytes, allowing melanoma cells to escape from immune …
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… and targeted therapy. Studies have shown that interferon-gamma (IFN-γ), a pro-tumorigenic cytokine in CM, induces the expression of programmed death-ligand 1 (PD-L1), leading to the escape of melanoma cells from immunosurveillance. Our previous study suggests that neuronal nitric oxide synthase …
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Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study
… IL-12p70, tumour necrosis factor-alpha and interferon-gamma (IFN-γ)) concentrations. Statistical analysis included assessment of normality using the Shapiro- Wilk test, with univariate one-way analysis of variance (ANOVA) of parametric data, and multiple independent Kruskal-Wallis ANOVA for …
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The influence of equine bone marrow derived stem cells on the response of cultured peripheral blood mononuclear cells to endotoxin
… (IL-6), interleukin-10 (IL-10), and interferon gamma (IFN-γ) were determined by ELISA. The immunogenic properties of MSCs were assessed with a one-way mixed lymphocyte reaction. In addition, the ability of MSCs to alter production of cytokines from stimulated PBMCs was assessed. TNF-α …
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Characterising the immunometabolic profile of HIV/TB co-infection
… by increased interleukin (IL)-6, and interferon-gamma (IFN-γ) when compared to the controls. The concomitant increase of cytokines typically classified as T helper cell type (Th) 1 or Th2, and as pro-inflammatory or immunoregulatory, suggests a failure of immunoregulation, resulting in …
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Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
… and the expression of nNOS is induced by interferon-gamma (IFN-γ). In our studies, nNOS has been implicated in IFN-γ-stimulated melanoma progression and the inhibition of nNOS using novel inhibitors effectively inhibited IFN-γ-stimulated tumor growth in a xenograft mouse model. Programmed …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
… timepoints. Unexpectedly, group 1 ILCs produce interferon gamma (IFN-γ) irrespective of contact with virus-infected cells, even in the uninfected epithelium, invoking an antiviral state independent of infection. Elimination of group 1 ILCs or neutralisation of IFN-γ decreased the expression of …
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Defining the functional response of Mycobacterium sp. infected macrophages to structural variants of Interferon gamma (IFN-y)
Interferon-gamma (IFN-γ) is a key cytokine that orchestrates immune defence through its antiviral, antimicrobial, and antitumour activities. Despite its central role in immune regulation, its broader therapeutic application has been constrained by an incomplete understanding of how subtle …
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The Immunology of Adeno-Associated Virus Serotype 2
… cell (PBMC) cultures from 16 donors elicited interferon-gamma (IFN-γ) (10 donors), interleukin-10 (IL-10) (8 donors) and interleukin-13 (IL-13) (4 donors). Using a series of overlapping peptides derived from the sequence of the VP1 viral capsid protein, a total of 59 candidate T-cell epitopes …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… (VEGF), programmed death ligand-1 (PD-L1), interferon-gamma (IFN-γ), and tumour burden in advanced melanoma patients. Furthermore, it sought to examine whether important differences exist in the plasma transcriptomic profile of advanced melanoma patients with a high disease burden compared …
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The effects of equine plasma transfusion on markers of inflammation in healthy neonatal foals
… 2) circulating cytokine concentration (interferon-gamma [IFN-γ], interleukin- 1β [IL-1 β], tumor necrosis factor-α [TNF- α], interleukin-6 [IL-6], interleukin-10 [IL-10] and interleukin-8 [IL-8], interleukin-4 [IL-4], interleukin-17 [IL-17]), and 3) changes in acute phase protein …
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Host-microbe interactions in the inflamed gut
… numbers were associated with significantly lower interferon gamma (IFN-γ) and IFN-γ-inducible protein (IP-10) mRNA levels as compared to the NCIMB-treated mice that were killed after 3 and 24 weeks of intervention. In conclusion, NCIMB was not capable of reducing gut inflammation in the IL-10-/- …
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Cellular Immunity in Mouse Models of Viral Encephalitis
… Unexpectedly, the VSV-induced interferon-gamma (IFN-γ) response in the CNS remained intact in mice rendered deficient of DCs suggesting that a resident brain cell produced this cytokine. In summary, these studies expanded prior work on the changes in resident microglia and the …
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Pharmacokinetic and Pharmacodynamic Studies of a Novel Spectinamide Series of Antituberculosis Agents
… and in a preliminary <em>in vivo </em>study in interferon gamma (IFN‑γ) knockout mice, spectinamide Lee1329 reduced the lung bacillary load of TB comparable to streptomycin. We hypothesized that the application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would …